Abstract: A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of interest is provided. Testis-derived rat Sertoli cells were pre-loaded with chitosan nanoparticles coupled with or without the drug curcumin, pre-labeled with a fluorescent cell marker and then injected intravenously into the control or asthmatic mouse model host. Intact pre-loaded, pre-labeled Sertoli cells were present in the lungs at 15 minutes post-injection, appeared entrapped in the pulmonary pre-capillary vascular bed around alveolar sacs but were not present one hour post-injection although Sertoli cell label and cellular debris was. Most of the injected nanoparticle load (70%) and curcumin load (80%) was present in the lungs 15 minutes post-injection, and remained at 70% and 80%, respectively, one hour post-injection.

Abstract: There is a transparent armor system. The system comprises a transparent front region comprising a strike-face layer. The front region includes a mass of a type of material characterized by having sufficient energy absorption capacity and energy dissipation properties to reduce radial tensile stresses and hoop tensile stresses caused by an impact at the strike face to a set reduced level. The impact has impact energy caused by an impact projectile having a mass hitting the strike-face layer. The system further comprises a transparent back region comprising a potassium-sodium exchanged glass characterized by having a surface compression of at least about 50,000 psi and a compression case depth of at least about 200 microns. The potassium-sodium exchanged glass is present in one of a layer and a plurality of layers in the back region. There are also associated methods of making and methods of using.

Abstract: A method and apparatus of detecting and using motion modes in a mobile device is described. Movement data is collected from an inertial motion unit (IMU) of the mobile device and compared to two or more sets of training data, each set of training data corresponding to a different motion mode. Then, a motion mode is determined to be the current mode of the mobile device on the results of the comparison. The motion mode is used by the mobile device in a variety of applications.

Abstract: The present invention provides a data mining framework for mining high-quality structured clinical information. The data mining framework includes a data miner that mines medical information from a computerized patient record (CPR) based on domain-specific knowledge contained in a knowledge base. The data miner includes components for extracting information from the CPR, combining all available evidence in a principled fashion over time, and drawing inferences from this combination process. The mined medical information is stored in a structured CPR which can be a data warehouse.

Abstract: A vehicle lighting module is provided that includes a lens having a plurality of near-field lens elements, an input surface, and an exit surface. The lighting module also includes an LED light source that directs incident light through the input surface and out of the exit surface. The plurality of lens elements is configured to transmit from the exit surface a collimated light pattern containing at least 60% of the incident light. Further, a vehicle headlamp assembly is provided that includes a plurality of vehicle lighting modules, each module comprising a lens, and an LED light source that directs incident light through the lens. The assembly further includes a case for housing the lighting modules. The lens includes a plurality of lens elements configured to transmit at least 60% of the incident light in a collimated, vehicular light pattern.

Abstract: A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, a cylindrical chamber and a plunger. The device is a single-use applicator designed in a shape similar to a tampon to facilitate its insertion through the vagina and into the uterus. Positioning of the device centrally in the uterus is accomplished through the use of ultrasound. The chamber is inserted into the tubular inserter. Adjusting the length of the chamber inserted into the tubular inserter controls the amount of tubing released from the apertures in the tubular inserter. Ultrasound is used to ensure the proper placement of each tube at the entrance of each fallopian tube. The plunger is inserted into the chamber and adjustment of the plunger controls the amount of the agent released into the tubes.

Abstract: A vehicle headlamp system includes a headlamp component with a reflecting element and a light source. The reflecting element includes an array of selectively controllable portions, and the light source provides a first output to the reflecting element. The system further includes a computer coupled to the light source and the reflecting element. The computer selectively operating the portions of the reflecting element to shape the first output into illumination areas according to at least one vehicle user characteristic.

Abstract: Systems and methods are disclosed for information management, which are performed substantially autonomously by a client in the absence of a storage manager connection, and which are also streamlined to operate efficiently when the storage manager connection is restored. The illustrative client, comprising specialized logic for operating autonomously, generates secondary copies of production data that are compatible with the information management system. The client stores the secondary copies to local fast-access primary storage technology. When connected to an appropriate media agent and to the storage manager, the client moves to efficiently offload the secondary data to a proper secondary storage subsystem. The client aggregates the locally-stored secondary copies into a consolidated data structure, which it transmits to the media agent in the form of a single job.

Abstract: A vehicle headlight includes a headlight housing including an external lens and an outer wall that define a headlight interior and a lighting element including a light-emitting diode lamp and an internal heatsink coupled to at least a portion of the lamp. The lamp is in thermal communication with the internal heatsink. The lighting element is disposed within the headlight interior and coupled to an element receptacle defined by the outer wall. The internal heatsink of the lighting element is in thermal communication with the external lens.

Abstract: A headlamp aimer box includes a housing defining an opening and a tunnel, a window disposed within the opening, and a whiteboard disposed at one end of the tunnel. The box further includes a mirror disposed within the tunnel. The mirror redirects a beam passing through the window from a headlamp toward the whiteboard. A length of the tunnel is such that light patterns directed by facets of the headlamp sufficiently cross a median line associated with the headlamp to form a developed beam on the whiteboard.

Abstract: A MEMS electrostatic actuator includes a bottom plate affixed to a substrate and a top plate suspended above the bottom plate. The top plate has a parallel plate center section and two rotating members electrically connected to the center section. Each rotating member is attached centrally of the rotating member for rotation about an axis of rotation to a set of anchor posts. The attachment includes at least one pair of torsional springs attached along each axis, each spring comprising a rectangular metal square that twists as the rotational members rotate. Electrostatic pull-down electrodes are underneath each rotational member.

Abstract: The present invention relates to the development of novel substituted 4,5-dihydro-2H-benzo[e]indazole-9-carboxylates, which can be used as therapeutic agents for the treatment and prevention of metabolic disorders, and a process of preparing said novel compounds. More particularly, the present invention relates to substituted 4,5-dihydro-2H-benzo[e]indazole-9-carboxylates and their related compounds, processes for preparing the said compounds and to their use in the treatment of diabetes and related metabolic disorders.

Abstract: The present invention is directed to a system and method for providing single instance storage of previously backed up data objects in archived backup storage, also known as data deduplication. Current deduplication methods implemented during backup and archiving of data do not work with previously backed up data. Previously backed up images may vary in format depending upon the method of backup and the type of backup system used. As a result, while future backup efforts may prevent multiple instances of backup data, previously backed up data may exist in multiple instances, wasting valuable storage space. The present invention decodes previously stored backup images for deduplication using an image adapter module that works cohesively with a deduplication engine, regardless of the format of the previously backed up images.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract: A system and method for tone mapping on a high dynamic range (HDR) image of a scene are disclosed. In one embodiment, tone mapping on the HDR image is performed using a set of bit-depths, that corresponds to a plurality of images of the scene, obtained at each unit of an irradiance range of the scene.

Abstract: A vehicular lighting assembly is provided that includes a chamber defined by isotropically luminant back and side surfaces, a depth, and a front surface having a lens aperture. The lighting assembly also includes LED sources on the back surface. In addition, each source has a beam angle?a light exit angle, and is spaced from the other sources?the depth divided by a predetermined factor between approximately 1.0 and 2.5. In certain aspects, the front surface also includes a diffuser. In other aspects, each source is spaced from the other sources?the depth divided by a predetermined factor of approximately 2.5 or less.

Abstract: There is disclosed a method and system for managing file metadata stored in one or more catalogs on a wireless handheld device. In an embodiment, the method comprises: connecting to one or more file libraries stored remotely from the device; downloading to the device one or more catalogs storing file metadata for one or more file libraries stored remotely from the device; and remotely updating on the device the one or more catalogs such that the file metadata in one or more file libraries stored remotely from the device are substantially up-to-date on the device.

Abstract: Methods and arrangements for creating and building subcategories in a user-based voice application. User posts are appended to a category in a voice application and subdivision of the category is prompted upon satisfaction of a first condition. The category is designated as a parent category, and at least one subcategory nomination are solicited from users. User input is solicited on appending at least one nominated subcategory to the parent category, and a nominated subcategory is appended to the parent category upon satisfaction of a second condition. User input is solicited to reassign a user post from the parent category to at least one subcategory.

Abstract: A semiconductor chip is described. The semiconductor chip includes a display controller having a driver. The display controller is configurable to select a first, a second, a third and a fourth different display interface. The driver is designed to drive respective signals for each of the first, second, third and fourth interfaces through a single output.

Abstract: Method and system for implementing a multiple writer single reader queue in a lock free and a contention free manner. The method includes receiving a plurality of payloads from a plurality of users, assigning each payload to a writer thread, creating a corresponding writer queue by each the writer threads, enqueuing queue entries into the writer queues maintained exclusively by the each of the writer threads and dequeuing sequentially the queue entries by a reader thread. Further, the method includes adding and removing one or more writer threads in real time. The system includes an electronic device for displaying a plurality of payloads. The system also includes a processor, a memory that stores instructions and a communication interface in electronic communication with the electronic device and the processor.