Patents by Inventor Arun Sreekumar
Arun Sreekumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230384316Abstract: Embodiments of the disclosure include means of identifying and quantifying particular metabolite-based biomarkers for diagnosis and prognosis of prostate cancer in African American men, including at least Methionine, Homocysteine, Glutamic acid, Ornithine, and/or Inosine, and, in some cases, also N-Acetyl Aspartate, Glutamine, Sarcosine, Succinate, and/or Malate.Type: ApplicationFiled: October 20, 2021Publication date: November 30, 2023Inventors: Arun Sreekumar, Bert W. O'Malley, Jie Gohlke, Clifford Dacso, Jeffrey Jones, George Michailidis, Nagireddy Putluri
-
Patent number: 10082510Abstract: Embodiments of the disclosure include methods and compositions for treatment of prostate cancer, including metastatic prostate cancer or prostate cancer at risk for developing into metastatic prostate cancer, by providing an effective therapy to an individual that has been determined to have elevated levels of SRC-2 (also known as NCOA2, GRIP1 TIF2). In particular cases, sample from an individual known to have prostate cancer is assayed for the risk for developing metastatic prostate cancer and the individual is provided an effective therapy upon determination of elevated levels of SRC-2.Type: GrantFiled: May 5, 2015Date of Patent: September 25, 2018Assignee: Baylor College of MedicineInventors: Bert W. O'Malley, Subhamoy Dasgupta, Nicholas Mitsiades, Arun Sreekumar, Sean E. Mcguire
-
Publication number: 20170067903Abstract: Embodiments of the disclosure include methods and compositions for treatment of prostate cancer, including metastatic prostate cancer or prostate cancer at risk for developing into metastatic prostate cancer, by providing an effective therapy to an individual that has been determined to have elevated levels of SRC-2 (also known as NCOA2, GRIP1 TIF2). In particular cases, sample from an individual known to have prostate cancer is assayed for the risk for developing metastatic prostate cancer and the individual is provided an effective therapy upon determination of elevated levels of SRC-2.Type: ApplicationFiled: May 5, 2015Publication date: March 9, 2017Applicant: Baylor College of MedicineInventors: Bert W. O'Malley, Subhamoy Dasgupta, Nicholas Mitsiades, Arun Sreekumar, Sean E. Mcguire
-
Publication number: 20140051601Abstract: The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.Type: ApplicationFiled: August 2, 2013Publication date: February 20, 2014Applicants: METABOLAN INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Arul M. Chinnaiyan, Arun Sreekumar, Matthew W. Mitchell, Kay A. Lawton, Alvin Berger, Christopher Beecher
-
Patent number: 7767393Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.Type: GrantFiled: January 31, 2006Date of Patent: August 3, 2010Assignee: The Regents of the University of MichiganInventors: Arul M. Chinnaiyan, Mark A. Rubin, Arun Sreekumar
-
Publication number: 20090075284Abstract: The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.Type: ApplicationFiled: August 15, 2008Publication date: March 19, 2009Applicants: The Regents of the University of Michigan, Metabolon, Inc.Inventors: Arul M. Chinnaiyan, Arun Sreekumar, Matthew W. Mitchell, Kay A. Lawton, Alvin Berger
-
Publication number: 20090047269Abstract: The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer and methods of inhibiting the growth of a cell by altering the level of such metabolites.Type: ApplicationFiled: August 15, 2008Publication date: February 19, 2009Applicant: The Regents of the University of MichiganInventors: Arul M. Chinnaiyan, Arun Sreekumar
-
Publication number: 20080280771Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of the phosphorylation status of protein samples, including the generation and analysis of protein microarrays.Type: ApplicationFiled: June 19, 2007Publication date: November 13, 2008Applicant: Regents of the University of MichiganInventors: David M. Lubman, Arul M. Chinnaiyan, Manoj Pal, Arun Sreekumar, Stephen P. Ethier
-
Publication number: 20080153711Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).Type: ApplicationFiled: June 20, 2007Publication date: June 26, 2008Applicant: Regents of the University of MichiganInventors: David M. Lubman, Arul M. Chinnaiyan, Manoj Pal, Arun Sreekumar, Stephen P. Ethier
-
Patent number: 7332290Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers. In particular, the present invention provides methods and compositions for the detection of ?-methylacyl-CoA racemase (AMACR) in the urine as a marker for prostate cancer detection.Type: GrantFiled: July 30, 2004Date of Patent: February 19, 2008Assignee: The Regents of the University of MichiganInventors: Mark A. Rubin, Arul M. Chinnaiyan, Bharathi Laxman, Arun Sreekumar
-
Patent number: 7229774Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.Type: GrantFiled: August 1, 2002Date of Patent: June 12, 2007Assignee: Regents of the University of MichiganInventors: Arul M. Chinnaiyan, Mark A. Rubin, Arun Sreekumar
-
Publication number: 20060211017Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.Type: ApplicationFiled: January 31, 2006Publication date: September 21, 2006Inventors: Arul Chinnaiyan, Mark Rubin, Arun Sreekumar
-
Publication number: 20050230315Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of the phosphorylation status of protein samples, including the generation and analysis of protein microarrays.Type: ApplicationFiled: March 30, 2005Publication date: October 20, 2005Applicant: Regents of the University of MichiganInventors: David Lubman, Arul Chinnaiyan, Manoj Pal, Arun Sreekumar, Stephen Ethier
-
Publication number: 20050136493Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers. In particular, the present invention provides methods and compositions for the use of ?-methylacyl-CoA racemase (AMACR) as a marker for prostate cancer detection and prognosis.Type: ApplicationFiled: July 30, 2004Publication date: June 23, 2005Applicant: The Regents of the University of MichiganInventors: Mark Rubin, Arul Chinnaiyan, Bharathi Laxman, Arun Sreekumar
-
Publication number: 20040214233Abstract: The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).Type: ApplicationFiled: January 13, 2004Publication date: October 28, 2004Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Arul M. Chinnaiyan, Arun Sreekumar, Bharathi Laxman, Fang Yan
-
Publication number: 20030175736Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.Type: ApplicationFiled: August 1, 2002Publication date: September 18, 2003Applicant: The Regents of the University of MichiganInventors: Arul M. Chinnaiyan, Mark A. Rubin, Arun Sreekumar