Abstract: The present invention describes peptides, peptides carriers, peptide nanobodies, and peptide-drug covalent conjugates having efficient cell and tissue penetration. The peptides and associated configurations can be used in covalent attachments or as complexes or nanoparticles in conjunction with therapeutic agents to enhance their tissue, cellular, and intracellular delivery. Also, the peptides and associated configurations can enhance binding to negatively charged matrices in the body for improved localization or retention of therapeutic carriers and agents.

Abstract: The present invention provides compositions and methods for treating an ocular condition and/or disease. In particular, compositions and methods of the invention are directed to a gene therapy for treatment of an ocular condition and/or disease. One particular aspect of the invention provides a recombinant DNA comprising (i) a therapeutic gene, a functional counterpart of a defective gene associated with manifestation said ocular condition or disease, or a combination thereof; and (ii) a delivery vehicle adapted for delivering said gene of (i) to cells in target ocular area for treating said ocular condition or disease, said delivery vehicle comprising an adeno-associated virus (AAV) serotype.

Abstract: This invention provides a process for obtaining bioactive recombinant protein from inclusion bodies without unfolding it completely into random coil structure. The process comprises solubilization of inclusion body protein using urea and propanol.