Abstract: Aspects of the present disclosure aim at configuring an optical time domain reflectometry (OTDR) in a central office such that the OTDR is configured to be operatively coupled with and also configured to periodically poll each fiber at defined intervals and compute/store a reflection signature that can be used to compare with future signatures received from subsequent polls of the fiber to determine a fault (e.g., a fiber cut or breakage) between the central office (CO) and one or more optical network unit (ONU) over GIS.

Abstract: In general, among other things, compounds of Formula I are provided: in which R11 is e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N1,N1,N3-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; R13 is, e.g., phenyl optionally substituted with one or more substituents; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided.

Abstract: A method for automatically converting note-to-self to action reminders in an electronic device is provided. The method includes receiving an input comprising at least one word from a user of the electronic device, analyzing an anaphora representation or a deictic representation for each of the at least one word, and generating a reminder based on a context from the anaphora representation or the deictic representation.

Abstract: The present invention provides a method and system for distributed probabilistic matrix factorization. In accordance with a disclosed embodiment, the method may include partitioning a sparse matrix into a first set of blocks on a distributed computer cluster, whereby a dimension of each block is MB rows and NB columns. Further, the method shall include initializing a plurality of matrices including first mean matrix ?, a first variance matrix ?, a first prior variance matrix ?P, a second mean matrix V, a second variance matrix {tilde over (V)}, and a second prior variance matrix {tilde over (V)}P, by a set of values from a probability distribution function. The plurality of matrices can be partitioned into a set of blocks on the distributed computer cluster, whereby each block can be of a shorter dimension K, and the plurality of matrices can be updated iteratively until a cost function of the sparse matrix converges.

Abstract: Anti-amyloid compounds are provided along with methods of use thereof.

Abstract: The present invention is directed to compounds that inhibit amyloid aggregation and methods of treatment therewith.

Abstract: The present invention is directed to compounds that inhibit amyloid aggregation and methods of treatment there-with.