Patents by Inventor Arunas Lagunavicius

Arunas Lagunavicius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymerase compositions and uses
    Patent number: 10435675
    Abstract: A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: October 8, 2019
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Arvydas Janulaitis
  • Delivery agent
    Patent number: 9856456
    Abstract: A composition comprising a polycationic agent and a polyanionic agent, and kits comprising the composition, is provided. In embodiments, the polyanionic agent is a nucleic acid and the polycationic agent is a modified polyalkyleneimine polymer.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 2, 2018
    Assignee: THERMO FISHER SCIENTIFIC BALTICS UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • POLYMERASE COMPOSITIONS AND USES
    Publication number: 20170267982
    Abstract: A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.
    Type: Application
    Filed: February 1, 2017
    Publication date: September 21, 2017
    Applicant: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Arvydas Janulaitis
  • DELIVERY AGENT
    Publication number: 20170152487
    Abstract: A composition comprising a polycationic agent and a polyanionic agent, and kits comprising the composition, is provided. In embodiments, the polyanionic agent is a nucleic acid and the polycationic agent is a modified polyalkyleneimine polymer.
    Type: Application
    Filed: September 24, 2015
    Publication date: June 1, 2017
    Applicant: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • Inactivation Method
    Publication number: 20170114339
    Abstract: The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.
    Type: Application
    Filed: January 20, 2016
    Publication date: April 27, 2017
    Inventors: Arunas LAGUNAVICIUS, Daiva TAURAITE, Jurgita BARKAUSKAITE, Leonas GRINIUS
  • Deoxyribonuclease Enzymes
    Publication number: 20170107501
    Abstract: Provided is a deoxyribonuclease comprising: (a) an amino acid sequence having at least 85% sequence identity with the sequence of a eukaryotic DNase I; and (b) an amino acid sequence capable of binding nucleic acid non-specifically comprising at least one helix-hairpin-helix motif.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 20, 2017
    Inventors: Gediminas ALZBUTAS, Arunas LAGUNAVICIUS, Milda KANIUSAITE
  • Polymerase compositions and uses
    Patent number: 9598679
    Abstract: A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 21, 2017
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Arvydas Janulaitis
  • Delivery agent
    Patent number: 9481862
    Abstract: A composition and method for delivering a peptide or protein into a cell comprising a polycationic agent and a polyanionic agent, wherein the polyanionic agent comprises an inorganic polyphosphate or a polyoxometalate and/or the polycationic agent comprises a polyalkyleneimine.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: November 1, 2016
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • Inactivation method
    Patent number: 9273304
    Abstract: The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: March 1, 2016
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Daiva Tauraite, Jurgita Barkauskaite, Leonas Grinius
  • DELIVERY AGENT
    Publication number: 20160024475
    Abstract: A composition comprising a polycationic agent and a polyanionic agent, and kits comprising the composition, is provided. In embodiments, the polyanionic agent is a nucleic acid and the polycationic agent is a modified polyalkyleneimine polymer.
    Type: Application
    Filed: September 24, 2015
    Publication date: January 28, 2016
    Applicant: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • Transfection reagent
    Patent number: 9102796
    Abstract: The present invention relates to a polyalkyleneimine polymer having a repeat unit comprising a hydrophilic group, agents containing the same and methods for their use.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: August 11, 2015
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Sarunas Zigmantas, Laurynas Riauba, Lolita Zaliauskiene, Richard Makuska, Ausvydas Vareikis, Ula Bernadisiute
  • Delivery agent
    Patent number: 8951957
    Abstract: A composition and method comprising a polycationic agent and a polyanionic agent for delivering a peptide or protein into a cell.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: February 10, 2015
    Assignee: Fermentas UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • DELIVERY AGENT
    Publication number: 20140120618
    Abstract: A composition and method for delivering a peptide or protein into a cell.
    Type: Application
    Filed: January 3, 2014
    Publication date: May 1, 2014
    Applicant: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • DELIVERY AGENT
    Publication number: 20110086794
    Abstract: A composition and method for delivering a peptide or protein into a cell.
    Type: Application
    Filed: October 11, 2010
    Publication date: April 14, 2011
    Applicant: FERMENTAS UAB
    Inventors: Arunas Lagunavicius, Lolita Zaliauskiene
  • POLYMERASE COMPOSITIONS AND USES
    Publication number: 20110059490
    Abstract: A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 10, 2011
    Applicant: Fermentas UAB
    Inventors: Arunas Lagunavicius, Arvydas Janulaitis
  • Transfection Reagent
    Publication number: 20100041739
    Abstract: The present invention relates to a polyalkyleneimine polymer having a repeat unit comprising a hydrophilic group, agents containing the same and methods for their use.
    Type: Application
    Filed: December 12, 2008
    Publication date: February 18, 2010
    Applicant: FERMENTAS UAB
    Inventors: Arunas Lagunavicius, Sarunas Zigmantas, Laurynas Riauba, Lolita Zaliauskiene, Richard Makuska, Ausvydas Vareikis, Ula Bernadisiute
  • Use of DNA polymerases
    Publication number: 20090202993
    Abstract: Use of a DNA polymerase enzyme as a single stranded RNA exoribonuclease.
    Type: Application
    Filed: October 26, 2007
    Publication date: August 13, 2009
    Applicant: Fermentas UAB
    Inventors: Arunas Lagunavicius, Arvydas Janulaitis, Zivile Kiveryte, Vilma Zimbaite-Ruskuliene, Agne Savaneviciute
  • Inactivation method
    Publication number: 20070224611
    Abstract: The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.
    Type: Application
    Filed: January 5, 2007
    Publication date: September 27, 2007
    Inventors: Arunas Lagunavicius, Daiva Tauraite, Jurgita Barkauskaite, Leonas Grinius