Patents by Inventor Arunava Manna

Arunava Manna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Divalent nucleobase compounds and uses therefor
    Patent number: 11713340
    Abstract: Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
    Type: Grant
    Filed: December 28, 2021
    Date of Patent: August 1, 2023
    Assignee: Carnegie Mellon University
    Inventors: Danith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
  • Divalent Nucleobase Compounds and Uses Therefor
    Publication number: 20220259266
    Abstract: Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
    Type: Application
    Filed: December 28, 2021
    Publication date: August 18, 2022
    Inventors: Danith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
  • Template-directed PNA synthesis process and PNA targeting compounds
    Patent number: 11319349
    Abstract: Described herein are recognition modules that bind specifically to a template nucleic acid and which ligate together in a reducing environment to produce a gamma peptide nucleic acid (?PNA) oligomer. Also provided are methods of synthesizing a ?PNA oligomer on a template using the recognition modules.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: May 3, 2022
    Assignee: Carnegie Mellon University
    Inventors: Danith H. Ly, Raman Bahal, Dinesh Chandra Bhunia, Yidan Cong, Arunava Manna, Srinivas Rapireddy
  • Divalent nucleobase compounds and uses therefor
    Patent number: 11236130
    Abstract: Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: February 1, 2022
    Assignee: Carnegie Mellon University
    Inventors: Danith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
  • Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
    Patent number: 10851407
    Abstract: A method of making optically pure preparations of chiral ?PNA (gamma peptide nucleic acid) monomers is provided. Nano structures comprising chiral ?PNA structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed ?PNA, and vice-versa, are provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: December 1, 2020
    Assignee: Carnegie Mellon University
    Inventors: Danith H. Ly, Wei-Che Hsieh, Iulia Sacui, Arunava Manna
  • Divalent Nucleobase Compounds and Uses Therefor
    Publication number: 20200087350
    Abstract: Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
    Type: Application
    Filed: June 19, 2019
    Publication date: March 19, 2020
    Inventors: Danith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
  • Template-Directed PNA Synthesis Process and PNA Targeting Compounds
    Publication number: 20190337986
    Abstract: Described herein are recognition modules that bind specifically to a template nucleic acid and which ligate together in a reducing environment to produce a gamma peptide nucleic acid (?PNA) oligomer. Also provided are methods of synthesizing a ?PNA oligomer on a template using the recognition modules.
    Type: Application
    Filed: January 17, 2019
    Publication date: November 7, 2019
    Inventors: Danith H. Ly, Raman Bahal, Dinesh Chandra Bhunia, Yidan Cong, Arunava Manna, Srinivas Rapireddy
  • Divalent nucleobase compounds and uses therefor
    Patent number: 10370415
    Abstract: Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: August 6, 2019
    Assignee: Carnegie Mellon University
    Inventors: Danith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
  • Template-directed ?PNA synthesis process and ?PNA targeting compounds
    Patent number: 10221216
    Abstract: Described herein are recognition modules that bind specifically to a template nucleic acid and which ligate together in a reducing environment to produce a gamma peptide nucleic acid (?PNA) oligomer. Also provided are methods of synthesizing a ?PNA oligomer on a template using the recognition modules.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: March 5, 2019
    Assignee: Carnegie Mellon University
    Inventors: Danith H. Ly, Raman Bahal, Arunava Manna, Dinesh Chandra Bhunia, Rapireddy Srinivas, Yidan Cong
  • Left-Handed Gamma-Peptide Nucleic Acids, Methods of Synthesis and Uses Therefor
    Publication number: 20170058325
    Abstract: A method of making optically pure preparations of chiral ?PNA (gamma peptide nucleic acid) monomers is provided. Nano structures comprising chiral ?PNA structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed ?PNA, and vice-versa, are provided.
    Type: Application
    Filed: May 8, 2015
    Publication date: March 2, 2017
    Inventors: Danith H. Ly, Wei-Che Hsieh, Iulia Sacui, Arunava Manna
  • TEMPLATE-DIRECTED GAMMAPNA SYNTHESIS PROCESS AND GAMMAPNA TARGETING COMPOUNDS
    Publication number: 20160083433
    Abstract: Described herein are recognition modules that bind specifically to a template nucleic acid and which ligate together in a reducing environment to produce a gamma peptide nucleic acid (?PNA) oligomer. Also provided are methods of synthesizing a ?PNA oligomer on a template using the recognition modules.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 24, 2016
    Applicant: Carnegie Mellon University
    Inventors: Danith H. Ly, Raman Bahal, Arunava Manna, Dinesh Chandra Bhunia, Srinivas Rapireddy, Yidan Cong
  • DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR
    Publication number: 20160083434
    Abstract: Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 24, 2016
    Applicant: Carnegie Mellon University
    Inventors: Danith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna