Patents by Inventor Arunkumar Easwaran

Arunkumar Easwaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREVENTING NON-SPECIFIC INTERACTIONS BETWEEN POLYMER DYES-ANTIBODY CONJUGATES
    Publication number: 20240125773
    Abstract: The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.
    Type: Application
    Filed: February 4, 2022
    Publication date: April 18, 2024
    Inventors: Frederic MONSONIS, Boi Hoa SAN, Arunkumar EASWARAN, Massimiliano TOMASULO, Sergei GULNIK, Rajesh VENKATESH, Shiva Ranjini SRINIVASAN
  • PHOTOACTIVE MACROMOLECULES AND USES THEREOF
    Publication number: 20240052092
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 15, 2024
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • POLYMER DYES AND USES THEREOF
    Publication number: 20230399565
    Abstract: The present disclosure provides fused dihydrophenanthrene (DHP) monomers and fluorescent fused DHP polymers, water-soluble fluorescent polymers and copolymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.
    Type: Application
    Filed: June 9, 2023
    Publication date: December 14, 2023
    Inventors: Massimiliano Tomasulo, Mukesh Mudgal, Arunkumar Easwaran, Sergei Gulnik
  • Photoactive macromolecules and uses thereof
    Patent number: 11834551
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: December 5, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • POLYMER DYE MODIFICATION AND APPLICATIONS
    Publication number: 20230192943
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: January 6, 2023
    Publication date: June 22, 2023
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Polymer dye modification and applications
    Patent number: 11584825
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: February 21, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • PHOTOACTIVE MACROMOLECULES AND USES THEREOF
    Publication number: 20220213260
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • Photoactive macromolecules and uses thereof
    Patent number: 11208527
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: December 28, 2021
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • POLYMER DYE MODIFICATION AND APPLICATIONS
    Publication number: 20200190253
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 18, 2020
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • PHOTOACTIVE MACROMOLECULES AND USES THEREOF
    Publication number: 20190144601
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 16, 2019
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • High performance luminescent compounds
    Patent number: 8273875
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: September 25, 2012
    Assignees: University of Notre Dame du Lac, Molecular Targeting Technologies, Inc.
    Inventors: Bradley Smith, Arunkumar Easwaran
  • HIGH PERFORMANCE LUMINESCENT COMPOUNDS
    Publication number: 20110118459
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.
    Type: Application
    Filed: November 16, 2009
    Publication date: May 19, 2011
    Applicants: University of Notre Dame du Lac, Molecular Targeting Technologies, Inc.
    Inventors: Bradley Smith, Arunkumar Easwaran