Patents by Inventor Arunthathi Thiagalingam

Arunthathi Thiagalingam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF DIFFERENTIALLY EXPRESSED NUCLEIC ACID SEQUENCES AS BIOMARKERS FOR CANCER
    Publication number: 20080233585
    Abstract: The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.
    Type: Application
    Filed: March 13, 2008
    Publication date: September 25, 2008
    Inventors: Christopher Burgess, Susan Myerow, Arunthathi Thiagalingam, Peter Maimonis, Gary Molino, Lawrence Burgart, Lisa Allyn Boardman, Stephen Thibodeau, Marcia Lewis
  • DETECTION METHODS USING TIMP1
    Publication number: 20080194043
    Abstract: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1? or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1? or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1? or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.
    Type: Application
    Filed: March 21, 2008
    Publication date: August 14, 2008
    Inventors: Jon H. ASTLE, Christopher C. BURGESS, Theodore J. CATINO, Poornima DWIVEDI, Maryanne HUNTRESS, Karen Anne JOHNSON, Marcia E. LEWIS, Peter J. MAIMONIS, Gary A. MOLINO, Susan H. MYEROW, Arunthathi THIAGALINGAM, Lisa Allyn BOARDMAN, Lawrence J. BURGART, Stephen N. THIBODEAU, Sheryl BROWN-SHIMER
  • Novel human genes and gene expression products: II
    Publication number: 20080131889
    Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
    Type: Application
    Filed: April 30, 2007
    Publication date: June 5, 2008
    Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
  • Method for detecting a differentially expressed sequence
    Patent number: 7258973
    Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: August 21, 2007
    Assignees: Mayo Foundation for Medical Education & Research, Bayer Healthcare, LLC
    Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen Thibodeau, Lawrence J. Burgart, Lisa Allyn Boardman
  • Human genes and gene expression products: II
    Patent number: 7211398
    Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: May 1, 2007
    Assignees: Bayer Corporation, Mayo Foundation for Medical Education and Research
    Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen Thibodeau, Lawrence J. Burgart, Lisa Allyn Boardman
  • Use of differentially expressed nucleic acid sequences as biomarkers for cancer
    Publication number: 20060188889
    Abstract: The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.
    Type: Application
    Filed: November 4, 2003
    Publication date: August 24, 2006
    Inventors: Christopher Burgess, Susan Myerow, Arunthathi Thiagalingam, Peter Maimonis, Gary Molino, Lawrence Burgart, Lisa Boardman, Stephen Thibodeau, Marcia Lewis
  • Nucleic acid sequences differentially expressed in cancer tissue
    Publication number: 20060179496
    Abstract: This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.
    Type: Application
    Filed: July 26, 2005
    Publication date: August 10, 2006
    Inventors: Christopher Burgess, Jon Astle, Eddie Carroll, Theodore Catino, Poornima Dwivedi, Gary Molino, Arunthathi Thiagalingam, Marcia Lewis, Stephen Thibodeau, Lawrence Burgart, Lisa Boardman
  • Differential expression of genes in microsatellite instability
    Publication number: 20060134653
    Abstract: The present invention relates to nucleic acid sequences which are overexpressed in colorectal tumors which display a high level of microsatellite instability (MSI-H) vs. tumors displaying a low level of microsatellite instability (MSS), and can thus be used to identify MSI-H in a patient, and be used further to facilitate patient prognosis, monitor disease progression/regression, identify appropriate treatment regimes, and evaluate the efficacy of treatment.
    Type: Application
    Filed: April 13, 2005
    Publication date: June 22, 2006
    Inventors: Christopher Burgess, Theodore Catino, Gary Molino, Susan Myerow, Arunthathi Thiagalingam, Marcia Lewis, Stephen Thibodeau, Lisa Boardman, Lawrence Burgart
  • Detection methods using TIMP 1
    Publication number: 20040157278
    Abstract: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1&agr; or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1&agr; or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1&agr; or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.
    Type: Application
    Filed: December 12, 2003
    Publication date: August 12, 2004
    Applicants: Bayer Corporation, Mayo Foundation for Medical Education & Research
    Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Maryanne Huntress, Karen Anne Johnson, Marcia E. Lewis, Peter J. Maimonis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Lisa Allyn Boardman, Lawrence J. Burgart, Stephen N. Thibodeau, Sheryl Brown-Shimer
  • Novel human genes and gene expression products
    Publication number: 20040146879
    Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 29, 2004
    Applicants: Bayer HealthCare LLC, Mayo Foundation for Medical Education & Research
    Inventors: Jon H. Astle, Lisa Allyn Boardman, Lawrence J. Burgart, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen N. Thibodeau
  • Nucleic acid sequences differentially expressed in cancer tissue
    Publication number: 20040110668
    Abstract: This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.
    Type: Application
    Filed: October 2, 2001
    Publication date: June 10, 2004
    Inventors: Christopher C. Burgess, Jon H. Astle, Eddie Carroll, Theodore J. Catino, Poornima Dwivedi, Gary A. Molino, Arunthathi Thiagalingam, Marcia E. Lewis
  • Novel human genes and gene expression products: II
    Publication number: 20030082620
    Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
    Type: Application
    Filed: October 25, 2002
    Publication date: May 1, 2003
    Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
  • Novel human genes and gene expressions products: II
    Publication number: 20020034758
    Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
    Type: Application
    Filed: July 17, 2001
    Publication date: March 21, 2002
    Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam