Abstract: Described herein relates to a system of and method for assessing adhesion properties of an adhesion component of at least one Transdermal Delivery System (hereinafter “TDS”) product using a skin-correlated probe. The present disclosure may comprise a skin-correlated probe configured to mimic a surface energy of human skin. Additionally, the skin-correlated probe of the system may be fabricated using additive manufacturing and/or additive layer manufacturing. Accordingly, the skin-correlated probe of the system may substantially decrease the adhesive force required to unbind the adhesive from the skin-correlated probe as compared to an industrial standard stainless steel probe. In addition, the system may be configured to be used for the in vitro in vivo correlation of the at least one TDS product.

Abstract: A composition, method of treating inflammation or edema, and method of increasing transdermal permeation and flux of at least one cannabinoid is presented. The composition is comprised of at least one cannabinoid, at least one permeation enhancer and at least one hydrophilic polymer. Administration of a therapeutically effective amount of this composition of can be used to treat both inflammation and edema in a patient as well as increasing transdermal permeation and flux of the at least one cannabinoid.

Abstract: Described herein relates to a multi-component adaptor assembly including a resin reservoir adaptor disposed on a printing surface of a preexisting additive manufacturing device, and including a build platform adaptor secured to a translatable arm of the preexisting additive manufacturing device. The resin reservoir adaptor is used to modify an existing resin reservoir by creating one or more smaller reservoirs within the larger housing, thereby reducing an amount of resin stored within the device to reduce resin waste. Moreover, the rotating and/or sliding build platform adaptor is designed to selectively contact one or more of the reservoirs of the resin reservoir adaptor, thereby selectively printing components of an additive manufactured process.

Abstract: A biocompatible resin composition that is used in the manufacture of a dissolvable microneedle that is used for the transdermal delivery of one or more active pharmaceutical ingredients to a subject. The biocompatible resin composition includes lithium phenyl-2,4,6-trimethylbenzoylphospinate, water, and poly(ethylene glycol) diacrylate (molecular weight 550), and may include methacrylated hyaluronic acid, that is capable of forming a structurally stable microneedle patch. The microneedle patch is formulated with the biocompatible resin composition using a continuous, one-step process utilizing additive manufacturing. Once manufactured, the microneedle patches are formulated to adhere to an outer layer of a subject's skin. Once administered to the subject, the microneedle compositions create microscopic pathways into the subject's subdermal layers to deliver one or more active agents to the subject, such as to the subject's bloodstream.

Abstract: A multi-component adaptor assembly including a resin reservoir adaptor disposed on a printing surface of a preexisting additive manufacturing device, and including a build platform adaptor secured to a translatable arm of the preexisting additive manufacturing device. The resin reservoir adaptor is used to modify an existing resin reservoir by creating one or more smaller reservoirs within the larger housing, thereby reducing an amount of resin stored within the device to reduce resin waste. Moreover, the rotating and/or sliding build platform adaptor is designed to selectively contact one or more of the reservoirs of the resin reservoir adaptor, thereby selectively printing components of an additive manufactured process. The multi-component adaptor assembly allows for additive manufacturing projects using less resin with fewer waste products; simultaneous printing of identical structures; and the selective printing of different components of a structure during a single printing cycle.

Abstract: A continuous process for preparing a solid lipid nanoparticle of ibuprofen utilizing hot melt extrusion which avoids additional steps such as high-pressure homogenization, ultrasonication, or solvent evaporation. The continuous process includes preparing a pre-emulsion comprising a lipid, and continuously processing the pre-emulsion through a hot melt extruder device.