Abstract: The present invention relates to a method of preparation of discrete particles of nanocrystalline solid dispersion, wherein said discrete particle comprises crystals of said active ingredient(s) in the matrix of the said crystallization inducer(s) and/or coexisting with crystals of crystallization inducer(s), optionally along with pharmaceutically acceptable excipient(s). An active ingredient and crystallization inducer is dissolved in a solvent or solvent mixture and then dried to obtain discrete particles of 0.5 to 20 micron size. Each particle consists of crystals of active ingredient in the range of 10-1000 nm dispersed in the matrix of crystallization inducer.

Abstract: The present invention relates to nanocrystalline solid dispersion compositions having discrete particles, wherein each discrete particle comprises crystals of at least one pharmaceutical active; veterinary active; nutraceutical active dispersed in the matrix of at least one crystallization inducer and/or coexisting with crystals of crystallization inducer, optionally along with pharmaceutically acceptable excipients. The present invention also encompasses a novel one-step process for generation of nanocrystalline solid dispersions. The present invention is particularly of use for improving the dissolution of pharmaceutical actives, veterinary actives; nutraceutical actives exhibiting dissolution-limited bioavailability. Dissolution enhancement is because of the decreased crystallite size of the pharmaceutical active.