Patents by Inventor Arvind Kumar Singla

Arvind Kumar Singla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of bipyridine compound ‘Caerulomycin A’ derivatives and analogs thereof as immunosuppressive agents
    Patent number: 8114895
    Abstract: The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4+ T cells, CD8+ T cells and B cells and in the production of IL-4 and IFN-? and antibodies. The compound operates through a mechanism by downregulating the expression of activation marker CD28 and upregulating the immunosuppressive marker CTLA-4. Caerulomycin A has previously been isolated from Streptomyces caeruleus and found to have useful antifungal activity. Prior to the present invention however, this compound had not been determined to have immunomodulatory activity.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: February 14, 2012
    Assignee: Council of Science and Industrial Research
    Inventors: Arvind Kumar Singla, Javed Naim Agrewala, Rakesh Mulraj Vohra, Ravinder Singh Jolly