Abstract: A liquid pump dispenser includes a vial adapter connected with a pump dispenser unit including a piston-type dispenser pump. When the vial adapter is coupled to the neck of a medical vial by latching, a piercing mandrel pierces a stopper sealing the vial. A fluid-tight communication between the vial adapter and pump dispenser unit is established by a flexible connecting tube, which helps to compensate mechanical tolerances and any misalignment or between the vial adapter and pump dispenser unit during assembly or use. The liquid pump dispenser can be used in an upside-down orientation of the medical vial without problems such as leakage or dripping at an outlet nozzle, and ensures a precise dosage of the liquid pumped from the medical vial. The vial adapter together with the pump dispenser unit can be pre-assembled and packaged as a unit.

Abstract: A method implemented through a data processing device of a computing network including includes detecting a point anomaly in real-time data associated with each network entity based on determining whether the real-time data falls outside a threshold expected value thereof, and representing the detected point anomaly in a full mesh Q node graph, with Q being a number of features applicable for the each network entity. The method also includes capturing a transition in the point anomaly associated with a newly detected anomaly or non-anomaly in the real-time data associated with one or more of the Q number of features via the representation of the full mesh Q node graph, and deriving a current data correlation score for the point anomaly across the captured transition via the representation of the full mesh Q node graph.

Abstract: A method implemented through a server of a cloud computing network including subscribers of application acceleration as a service provided therethrough includes detecting a set of point anomalies in real-time data associated with each network entity for each feature thereof, and, in accordance with reading anomaly scores associated with an event as an input feedback, the each feature of the each network entity as a dimension of the input feedback and a category of the event as a label thereof, predictively classifying a future event into a predicted category in accordance with subjecting the anomaly scores associated with the event to a binning process and interpreting a severity indicator of the event. The method also includes refining the predictive classification of the future event based on a subsequent input to the server from a client device modifying a classification model for predictively classifying the future event into the predicted category.

Abstract: A method implemented through a server of a cloud computing network including subscribers of application acceleration as a service provided therethrough includes detecting a set of point anomalies in real-time data associated with each network entity for each feature thereof, and determining at least a subset of the set of point anomalies as a sequential series of continuous anomalies based on a separation in time between immediately next point anomalies thereof. The method also determining a current longest occurring sequence of anomalies in the set of point anomalies, and, in light of new point anomalies of the set of point anomalies in the real-time data detected, improving performance of determination of a subsequent longest occurring sequence of anomalies in the set of point anomalies based on combining the determined current longest occurring sequence of anomalies incrementally with one or more new point anomalies.

Abstract: A medical device for intradermal injection comprises an injection device 6 and a guiding device 1, which is placed on the skin surface 100 of a subject and comprises a tubular guiding device 2 to guide an axial movement of the injection device 6 toward the skin surface 100. A sleeve-shaped guiding portion 32, 33 tightly matches the profile at the distal end of the injection device 6 to prevent a tilting of the injection device 6 at a foremost distal position of the injection device 6 in the tubular guiding device 2. A positive-fit locking member 24 is provided at a side proximal to the sleeve-shaped guiding portion 32, 33, for locking the foremost distal position of the injection device 6 and coupling the injection device 6 to the guiding device 1. Locking of the injection device generates a sound, indicating that the medical device is ready for injection.

Abstract: A method implemented through a server of a cloud computing network including subscribers of application acceleration as a service provided therethrough includes detecting a set of point anomalies in real-time data associated with each network entity for each feature thereof, and determining at least a subset of the set of point anomalies as a sequential series of continuous anomalies based on a separation in time between immediately next point anomalies thereof. The method also determining a current longest occurring sequence of anomalies in the set of point anomalies, and, in light of new point anomalies of the set of point anomalies in the real-time data detected, improving performance of determination of a subsequent longest occurring sequence of anomalies in the set of point anomalies based on combining the determined current longest occurring sequence of anomalies incrementally with one or more new point anomalies.

Abstract: A method implemented through a server of a cloud computing network including subscribers of application acceleration as a service provided therethrough includes detecting a set of point anomalies in real-time data associated with each network entity for each feature thereof, and, in accordance with reading anomaly scores associated with an event as an input feedback, the each feature of the each network entity as a dimension of the input feedback and a category of the event as a label thereof, predictively classifying a future event into a predicted category in accordance with subjecting the anomaly scores associated with the event to a binning process and interpreting a severity indicator of the event. The method also includes refining the predictive classification of the future event based on a subsequent input to the server from a client device modifying a classification model for predictively classifying the future event into the predicted category.

Abstract: A liquid pump dispenser includes a vial adapter connected with a pump dispenser unit including a piston-type dispenser pump. When the vial adapter is coupled to the neck of a medical vial by latching, a piercing mandrel pierces a stopper sealing the vial. A fluid-tight communication between the vial adapter and pump dispenser unit is established by a flexible connecting tube, which helps to compensate mechanical tolerances and any misalignment or between the vial adapter and pump dispenser unit during assembly or use. The liquid pump dispenser can be used in an upside-down orientation of the medical vial without problems such as leakage or dripping at an outlet nozzle, and ensures a precise dosage of the liquid pumped from the medical vial. The vial adapter together with the pump dispenser unit can be pre-assembled and packaged as a unit.

Abstract: A tray for positioning, in a fixed positional relationship, a medical vial 7 together with a vial adapter 4 is disclosed. A tray member 10 includes a vial accommodation cavity 11 and a vial adapter accommodation cavity 12, each comprises retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b configured to position the vial adapter 4 and the vial 7 spaced apart from each other and in axial alignment in an intermediate position. The retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b are further configured to guide a relative axial movement of the vial 7 and vial adapter 4 from the intermediate position to a transfer position while maintaining the axial alignment of the vial 7 with the vial adapter 4. In the transfer position the vial adapter 4 is locked to the vial 7 and a piercing mandrel 57 pierces a vial stopper 76 for liquid transfer.

Abstract: A method implemented through a data processing device in a computing network includes sampling time series data associated with each network entity for each feature thereof into a smaller time interval as a first data series and a second data series including a maximum value and a minimum value respectively of the sampled time series data for the each feature within the smaller time interval, and generating a reference data band from predicted future data sets. The method also includes detecting, based on the reference data band, an anomaly in real-time data associated with the each network entity for the each feature thereof, and determining an event associated with a pattern of change of the real-time data associated with the each network entity based on executing an optimization algorithm to determine a series of anomalies including the detected anomaly.

Abstract: A method implemented through a data processing device of a computing network including includes detecting a point anomaly in real-time data associated with each network entity based on determining whether the real-time data falls outside a threshold expected value thereof, and representing the detected point anomaly in a full mesh Q node graph, with Q being a number of features applicable for the each network entity. The method also includes capturing a transition in the point anomaly associated with a newly detected anomaly or non-anomaly in the real-time data associated with one or more of the Q number of features via the representation of the full mesh Q node graph, and deriving a current data correlation score for the point anomaly across the captured transition via the representation of the full mesh Q node graph.

Abstract: A method implemented through a server of a cloud computing network including subscribers of application acceleration as a service provided therethrough includes detecting a point anomaly in real-time data associated with each network entity based on determining whether the real-time data falls outside a threshold expected value thereof, and representing the detected point anomaly in a full mesh Q node graph, with Q being a number of features applicable for the each network entity. The method also includes capturing a transition in the point anomaly associated with a newly detected anomaly or non-anomaly in the real-time data associated with one or more of the Q number of features via the representation of the full mesh Q node graph, and deriving a current data correlation score for the point anomaly across the captured transition via the representation of the full mesh Q node graph.

Abstract: An apparatus for combining a first liquid component 90 stored in a container 125 and a second component stored in a vial 7 by means of negative pressure is disclosed. A tray 1 has a vial cavity 11 and a container cavity 12. A dual-ended transfer needle 131 is fixedly held at the tray 1 at an intermediate needle holding portion 13 between the vial cavity 11 and the container cavity 12 for establishing a fluid communication between the vial 7 and the container 125 by piercing a rubber stopper of the vial and a bottom of the container, respectively. The vial cavity 11 guides the vial 7 along an axial direction AD from an intermediate position towards the transfer position for fluid communication. And the container cavity 12 guides the container 125 along the axial direction AD from an intermediate position towards the transfer position for fluid communication.

Abstract: A tubular locking body of a tamper evident plastic closure for necked vials for holding a plug in a mouth of a vial includes a retaining member for retaining the plug, a central opening being formed in the retaining member for providing access to the inside of the vial via the plug. The cap includes a disc-shaped cover and a coupling portion, for coupling the cap with the tubular locking body by positive-fit engagement. The coupling portion includes at least one frangible portion each configured such that at least one indicator member remains as a tamper evidence at a rim of the central opening of the tubular locking body after removal of the cap from the distal end of the tubular locking body by irreversibly breaking the annular frangible portion for providing access to the inside of the vial via the plug.

Abstract: A tablet formed from a pre-lyophilization solution has a void in its bottom surface, with a void height that is about 60% to 100% of a depth of the tablet. A pharmaceutical dosage form includes a blister sheet having one or more cavities, each having a protrusion extending upwardly from the cavity floor, with a tablet formed in the cavity by lyophilization of a pre-lyophilization solution in each such cavity. The protrusion is a cylinder or tapered cylinder and the void has a corresponding shape. A film overlays the blister sheet to seal the tablet in the blister sheet cavities.

Abstract: A lyophilization promoting element to facilitate the transfer of heat between a lyophilizer and a pre-lyophilization solution. The element includes a base plate with a plurality of apertures. The base plate is made of a thermally conductive material and the apertures are regularly arranged within the base plate, each aperture being sized to receive a pharmaceutical vial container containing a pre-lyophilization solution. A method of lyophilizing includes inserting one or more pharmaceutical vial containers into the plurality of apertures of the lyophilization promoting element and placing the lyophilization promoting element holding the one or more pharmaceutical vial containers on a shelf of a lyophilizer.