Patents by Inventor Arvydas Maminishkis
Arvydas Maminishkis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115261Abstract: A surgical clamp for aligning the margins of incised or wounded tissue has jaws with parallel clamping faces, and a handle for manipulating the clamp to align the margins of the tissue. The jaws are in a normally closed position, however they can be opened by compressing the handle to open the jaws. Prongs project from the inferior surface of the jaws. The clamp is positioned in a desired position over the margins of a wound to be closed, the prongs engage the margins of the wound to be aligned, and the jaws are closed by releasing compressive force on the handle. As the jaws close the prongs help move the tissue into alignment. Suture guide slots through the jaws assist in the placement of precisely placed sutures across the incision. The disclosed surgical clamp is particularly suited for selectively closing and reopening surgical incisions, such as a sclerotomy incision in the eye. Methods are disclosed for using the clamp during intraocular and other surgical or minimally invasive procedures.Type: ApplicationFiled: July 25, 2023Publication date: April 11, 2024Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Vladimir R. Khristov, Steven T. Charles, Juan A. Amaral, Arvydas Maminishkis, Kapil Bharti
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Publication number: 20240041650Abstract: Disclosed are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion.Type: ApplicationFiled: August 14, 2023Publication date: February 8, 2024Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventor: Arvydas Maminishkis
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Patent number: 11723799Abstract: Disclosed are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion.Type: GrantFiled: June 24, 2020Date of Patent: August 15, 2023Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventor: Arvydas Maminishkis
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Patent number: 11717298Abstract: A surgical clamp for aligning the margins of incised or wounded tissue has jaws with parallel clamping faces, and a handle for manipulating the clamp to align the margins of the tissue. The jaws are in a normally closed position, however they can be opened by compressing the handle to open the jaws. Prongs project from the inferior surface of the jaws. The clamp is positioned in a desired position over the margins of a wound to be closed, the prongs engage the margins of the wound to be aligned, and the jaws are closed by releasing compressive force on the handle. As the jaws close the prongs help move the tissue into alignment. Suture guide slots through the jaws assist in the placement of precisely placed sutures across the incision. The disclosed surgical clamp is particularly suited for selectively closing and reopening surgical incisions, such as a sclerotomy incision in the eye. Methods are disclosed for using the clamp during intraocular and other surgical or minimally invasive procedures.Type: GrantFiled: November 8, 2017Date of Patent: August 8, 2023Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Vladimir R. Khristov, Steven T. Charles, Juan A. Amaral, Arvydas Maminishkis, Kapil Bharti
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Publication number: 20230212509Abstract: Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer.Type: ApplicationFiled: May 28, 2021Publication date: July 6, 2023Applicants: FUJIFILM Cellular Dynamics, Inc., The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Andrew DIAS, Erich BERNDT, Lucas CHASE, Juan AMARAL, Arvydas MAMINISHKIS, Kapil BHARTI
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Publication number: 20220389505Abstract: High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.Type: ApplicationFiled: July 15, 2022Publication date: December 8, 2022Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicInventors: Kapil Bharti, Janine Davis, Arvydas Maminishkis, Marc Ferrer-Alegre, Sheldon S. Miller
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Patent number: 11441184Abstract: High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.Type: GrantFiled: September 27, 2019Date of Patent: September 13, 2022Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicesInventors: Kapil Bharti, Janine Davis, Arvydas Maminishkis, Sheldon S. Miller
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Publication number: 20200315843Abstract: Disclosed are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion.Type: ApplicationFiled: June 24, 2020Publication date: October 8, 2020Applicant: National Institutes of HealthInventor: Arvydas Maminishkis
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Patent number: 10729579Abstract: Described are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion.Type: GrantFiled: July 10, 2015Date of Patent: August 4, 2020Assignee: National Institutes of HealthInventor: Arvydas Maminishkis
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Publication number: 20200178964Abstract: A surgical clamp for aligning the margins of incised or wounded tissue has jaws with parallel clamping faces, and a handle for manipulating the clamp to align the margins of the tissue. The jaws are in a normally closed position, however they can be opened by compressing the handle to open the jaws. Prongs project from the inferior surface of the jaws. The clamp is positioned in a desired position over the margins of a wound to be closed, the prongs engage the margins of the wound to be aligned, and the jaws are closed by releasing compressive force on the handle. As the jaws close the prongs help move the tissue into alignment. Suture guide slots through the jaws assist in the placement of precisely placed sutures across the incision. The disclosed surgical clamp is particularly suited for selectively closing and reopening surgical incisions, such as a sclerotomy incision in the eye. Methods are disclosed for using the clamp during intraocular and other surgical or minimally invasive procedures.Type: ApplicationFiled: November 8, 2017Publication date: June 11, 2020Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICInventors: Vladimir R. Khristov, Steven T. Charles, Juan A. Amaral, Arvydas Maminishkis, Kapil Bharti
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Publication number: 20180291448Abstract: High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.Type: ApplicationFiled: May 2, 2018Publication date: October 11, 2018Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServInventors: Kapil Bharti, Janine Davis, Arvydas Maminishkis, Marc Ferrer-Alegre, Sheldon S. Miller
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Publication number: 20170128263Abstract: Disclosed are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion.Type: ApplicationFiled: July 10, 2015Publication date: May 11, 2017Applicant: National Institutes of HealthInventor: Arvydas Maminishkis
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Patent number: 9486502Abstract: Particular aspects of the invention provide methods for decreasing the amount of fluid present in the subretinal space of the eye by administering interferon gamma to the basolateral side of the retinal pigment epithelium. Adverse ocular conditions associated with the accumulation of fluid in the subretinal space can be treated by administering an amount of interferon gamma to the basolateral side of the retinal pigment epithelium effective to remove excess fluid from the subretinal space.Type: GrantFiled: April 14, 2014Date of Patent: November 8, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Rong Li, Sheldon S. Miller, Arvydas Maminishkis
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Publication number: 20150368713Abstract: High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.Type: ApplicationFiled: January 31, 2014Publication date: December 24, 2015Applicant: THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human ServInventors: Kapil Bharti, Janine Davis, Arvydas Maminishkis, Marc Ferrer-Alegre, Sheldon S. Miller
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Publication number: 20150265679Abstract: What is described is a method for treating an adverse side effect of MEK inhibitors by administering a pharmaceutical composition comprising IFN? to a cancer patient being treated by a MEK-inhibitor. The applicants discovered that MEK inhibitors produce unwanted visual disturbances as an adverse side effect in a significant fraction of cancer patients being treated by the drug, and that the side effect causes retinal detachment due to fluid accumulation in the eye. The method treats the retinal detachment caused by the anticancer therapeutic by providing a means of decreasing the amount of fluid present in the retina and/or subretinal space of the eye by administering the pharmaceutical composition comprising IFN? to the basolateral side of the retinal pigment epithelium, preferably by administering the pharmaceutical composition to the anterior surface of the eye in liquid droplets.Type: ApplicationFiled: November 1, 2013Publication date: September 24, 2015Applicant: The United States of America, as represented by Secretary, Department of Health and Human ServicesInventors: Sheldon S. Miller, Arvydas Maminishkis, Charlotte E. Reme
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Publication number: 20140328901Abstract: Particular aspects of the invention provide methods for decreasing the amount of fluid present in the subretinal space of the eye by administering interferon gamma to the basolateral side of the retinal pigment epithelium. Adverse ocular conditions associated with the accumulation of fluid in the subretinal space can be treated by administering an amount of interferon gamma to the basolateral side of the retinal pigment epithelium effective to remove excess fluid from the subretinal space.Type: ApplicationFiled: April 14, 2014Publication date: November 6, 2014Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Rong Li, Sheldon S. Miller, Arvydas Maminishkis
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Patent number: 8710026Abstract: Embodiments of the invention provide methods of preventing or treating detrimental epithelial cell proliferation, loss of epithelial cell differentiation, age-related macular degeneration and/or proliferative vitreal retinopathy in an individual comprising administering to an individual in need thereof an effective amount of miR 204, an effective amount of miR 211, or an effective amount of a mixture of miR 204 and miR 211. A further embodiment of the invention provides a method of facilitating the transport of a substance across an epithelium in an individual comprising administrating to an individual an effective amount of anti-miR 204, an effective amount of anti-miR 211, or an effective amount of a mixture of anti-miR 204 and anti-miR 211. Additional embodiments of the invention include pharmaceutical compositions of miR 204 and/or miR 211 and pharmaceutical compositions of anti-miR 204 and/or anti-miR 211.Type: GrantFiled: May 16, 2013Date of Patent: April 29, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Sheldon Miller, Congxiao Zhang, Arvydas Maminishkis, Fei Wang
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Patent number: 8697046Abstract: Particular aspects of the invention provide methods for decreasing the amount of fluid present in the subretinal space of the eye by administering interferon gamma to the basolateral side of the retinal pigment epithelium. Adverse ocular conditions associated with the accumulation of fluid in the subretinal space can be treated by administering an amount of interferon gamma to the basolateral side of the retinal pigment epithelium effective to remove excess fluid from the subretinal space.Type: GrantFiled: August 14, 2009Date of Patent: April 15, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Rong Li, Sheldon S. Miller, Arvydas Maminishkis
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Patent number: 8455454Abstract: Embodiments of the invention provide methods of preventing or treating detrimental epithelial cell proliferation, loss of epithelial cell differentiation, age-related macular degeneration and/or proliferative vitreal retinopathy in an individual comprising administering to an individual in need thereof an effective amount of miR 204, an effective amount of miR 211, or an effective amount of a mixture of miR 204 and miR 211. A further embodiment of the invention provides a method of facilitating the transport of a substance across an epithelium in an individual comprising administrating to an individual an effective amount of anti-miR 204, an effective amount of anti-miR 211, or an effective amount of a mixture of anti-miR 204 and anti-miR 211. Additional embodiments of the invention include pharmaceutical compositions of miR 204 and/or miR 211 and pharmaceutical compositions of anti-miR 204 and/or anti-miR 211.Type: GrantFiled: August 26, 2009Date of Patent: June 4, 2013Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Fei Wang, Sheldon Miller, Congxiao Zhang, Arvydas Maminishkis
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Publication number: 20110305668Abstract: Particular aspects of the invention provide methods for decreasing the amount of fluid present in the subretinal space of the eye by administering interferon gamma to the basolateral side of the retinal pigment epithelium. Adverse ocular conditions associated with the accumulation of fluid in the subretinal space can be treated by administering an amount of interferon gamma to the basolateral side of the retinal pigment epithelium effective to remove excess fluid from the subretinal space.Type: ApplicationFiled: August 14, 2009Publication date: December 15, 2011Applicant: The United States of America, as represented by the Secretary, Dept.of Health and Human ServicesInventors: Rong Li, Sheldon S. Miller, Arvydas Maminishkis