Patents by Inventor Arya Biragyn
Arya Biragyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10300115Abstract: The instant invention provides methods and compositions for modulation of the immune system. Specifically, the present disclosure provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.Type: GrantFiled: January 11, 2017Date of Patent: May 28, 2019Assignee: The United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arya Biragyn, Kouji Matsushima, Dolgor Baatar
-
Publication number: 20170119858Abstract: The instant invention provides methods and compositions for modulation of the immune system. Specifically, the present disclosure provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.Type: ApplicationFiled: January 11, 2017Publication date: May 4, 2017Inventors: Arya Biragyn, Kouji Matsushima, Dolgor Baatar
-
Patent number: 9605044Abstract: The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.Type: GrantFiled: June 24, 2014Date of Patent: March 28, 2017Assignee: The United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arya Biragyn, Kouji Matsushima, Dolgor Baatar
-
Publication number: 20140341937Abstract: The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.Type: ApplicationFiled: June 24, 2014Publication date: November 20, 2014Applicant: The United States of America, as represented by the Secretary, Department of Health & Human ServicInventors: Arya Biragyn, Kouji Matsushima, Dolgor Bataar
-
Patent number: 8795674Abstract: The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.Type: GrantFiled: September 28, 2006Date of Patent: August 5, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arya Biragyn, Kouji Matsushima, Dolgor Bataar
-
Publication number: 20110135715Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: ApplicationFiled: February 1, 2011Publication date: June 9, 2011Inventors: Larry W. Kwak, Arya Biragyn
-
Publication number: 20110110947Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: ApplicationFiled: January 19, 2011Publication date: May 12, 2011Inventors: Larry W. Kwak, Arya Biragyn
-
Publication number: 20110081370Abstract: The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.Type: ApplicationFiled: September 28, 2006Publication date: April 7, 2011Applicant: Government of the US, as represented by the Secretary, Dept of Health and Human ServicesInventors: Arya Biragyn, Kouji Matsushima, Dolgor Bataar
-
Patent number: 7915040Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: GrantFiled: May 24, 2010Date of Patent: March 29, 2011Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Larry W. Kwak, Arya Biragyn
-
Patent number: 7897152Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: GrantFiled: September 17, 2001Date of Patent: March 1, 2011Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Larry W. Kwak, Arya Biragyn
-
Publication number: 20100260793Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: ApplicationFiled: May 24, 2010Publication date: October 14, 2010Applicants: Office of Technology Transfer, National Institutes of HealthInventors: Larry W. Kwak, Arya Biragyn
-
Patent number: 7754676Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: GrantFiled: September 17, 2001Date of Patent: July 13, 2010Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Larry W. Kwak, Arya Biragyn
-
Publication number: 20090068234Abstract: The instant invention provides compositions for the treatment of cancer. Specifically, the invention provides polypeptides and nucleic acid molecules comprising tumor-associated embryonic antigens, e.g., OFA-iLRP, and chemoattractant ligands, e.g., a proinflammatory chemokine such as MIP3?/CCL20 or ?-defensin mDF2?. The invention further provides cancer vaccines and methods for treating subjects having, or at risk of developing, cancer.Type: ApplicationFiled: September 3, 2007Publication date: March 12, 2009Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Arya Biragyn, Dan Longo, Igor Espinoza-Delgado
-
Publication number: 20050095257Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: ApplicationFiled: September 17, 2001Publication date: May 5, 2005Inventors: Larry Kwak, Arya Biragyn
-
Publication number: 20040110165Abstract: The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.Type: ApplicationFiled: March 17, 2003Publication date: June 10, 2004Inventors: Larry W. Kwak, Arya Biragyn
-
Publication number: 20030138452Abstract: The present invention provides a fusion polypeptide comprising a chemokine and either a tumor or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing HIV infection.Type: ApplicationFiled: December 31, 2002Publication date: July 24, 2003Inventors: Larry W. Kwak, Arya Biragyn
-
Patent number: 6562347Abstract: The present invention provides a fusion polypeptide comprising a chemokine and either a tumor or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing HIV infection.Type: GrantFiled: September 12, 2000Date of Patent: May 13, 2003Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Larry W. Kwak, Arya Biragyn