Patents by Inventor Aryeh Batt
Aryeh Batt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240122697Abstract: The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cType: ApplicationFiled: December 21, 2023Publication date: April 18, 2024Inventors: Ariel EISENBACH, Amos EITAN, Michal MARCUS, Maayan MALKI, Lior ROSENBERG BELMAKER, Shai GARTY, Rajesh KUMAR, Lior SHAV, Aryeh BATT
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Publication number: 20230310709Abstract: A method of manufacturing a retinal graft. The method includes: (a) preparing a scaffold material solution; (b) air-drying the scaffold material solution, to form a thin scaffold layer; (c) crosslinking the thin scaffold layer; (d) rehydrating the scaffold layer; and (e) applying retinal pigment epithelium cells onto the scaffold layer.Type: ApplicationFiled: April 2, 2023Publication date: October 5, 2023Inventors: Amos EITAN, Aryeh Batt, Ariel Eisenbach, Dorin Sade Yazdi, Michal Marcus, Lior Rosenberg Belmaker, Maayan Malki, Gal Shenbach-Koltin
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Publication number: 20230172704Abstract: The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cType: ApplicationFiled: December 26, 2022Publication date: June 8, 2023Inventors: Ariel EISENBACH, Amos EITAN, Michal MARCUS, Lior ROSENBERG BELMAKER, Shai GARTY, Rajesh KUMAR, Lior SHAV, Aryeh BATT
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Publication number: 20230000617Abstract: The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cType: ApplicationFiled: October 6, 2020Publication date: January 5, 2023Inventors: Ariel EISENBACH, Amos EITAN, Michal MARCUS, Lior ROSENBERG BELMAKER, Shai GARTY, Rajesh KUMAR, Lior SHAV, Aryeh BATT
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Patent number: 11498352Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.Type: GrantFiled: October 24, 2019Date of Patent: November 15, 2022Assignee: PRECISE BIO INC.Inventor: Aryeh Batt
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Publication number: 20220288276Abstract: The present invention discloses an artificial endothelial keratoplasty graft consisting a support layer made of rehydrated crosslinked hydrogel and corneal endothelial cells on top or within said support layer. The invention also discloses a method of manufacturing an artificial endothelial keratoplasty graft, wherein said method consisting of a step of drying support layer material followed by a crosslinking step.Type: ApplicationFiled: March 11, 2021Publication date: September 15, 2022Inventors: Aryeh BATT, Amos EITAN, Ariel EISENBACH, Yishay HAYARDENI, Mehwish KHAN, Michal MARCUS, Kanti NEPAL, Khanh NGUYEN, Lior SHAV, Yan WU
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Patent number: 10940687Abstract: Methods and systems for Laser-Induced Forward Transfer are disclosed in which a microfluidic chip is used as the printing head. The head comprises a transparent upper region, a middle region comprising an intermediate layer channel and an ink channel in fluid connection with said intermediate layer channel, and a lower layer with an orifice in fluid contact with the ink channel. When material in the intermediate layer channel is irradiated by an energy source (typically a pulsed laser) at a spot opposite the orifice, the material is partially evaporated, creating a vapor bubble that creates a transient pressure increase when it collapses, thereby forcing ink out of the orifice and onto a receiving substrate.Type: GrantFiled: April 16, 2018Date of Patent: March 9, 2021Assignees: Precise Bio Inc, Precise Bio 3D LTDInventors: Aryeh Batt, Amos Eitan, Ariel Eisenbach
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Patent number: 10668762Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir (9) comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.Type: GrantFiled: July 31, 2017Date of Patent: June 2, 2020Assignee: PRECISE BIO INC.Inventor: Aryeh Batt
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Publication number: 20200070514Abstract: Methods and systems for Laser-Induced Forward Transfer are disclosed in which a microfluidic chip is used as the printing head. The head comprises a transparent upper region, a middle region comprising an intermediate layer channel and an ink channel in fluid connection with said intermediate layer channel, and a lower layer with an orifice in fluid contact with the ink channel. When material in the intermediate layer channel is irradiated by an energy source (typically a pulsed laser) at a spot opposite the orifice, the material is partially evaporated, creating a vapor bubble that creates a transient pressure increase when it collapses, thereby forcing ink out of the orifice and onto a receiving substrate.Type: ApplicationFiled: April 16, 2018Publication date: March 5, 2020Inventors: Aryeh Batt, Amos Eitan, Ariel Eisenbach
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Publication number: 20200055326Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.Type: ApplicationFiled: October 24, 2019Publication date: February 20, 2020Inventor: Aryeh BATT
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Publication number: 20200055327Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.Type: ApplicationFiled: October 24, 2019Publication date: February 20, 2020Inventor: Aryeh BATT
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Publication number: 20180050550Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir (9) comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.Type: ApplicationFiled: July 31, 2017Publication date: February 22, 2018Applicant: PHOTON JET LTD.Inventor: Aryeh BATT
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Patent number: 9751351Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir (9) comprising at least one opening; and an energy source configured to deliver energy to a donor material within said reservoir. In preferred embodiments of the invention, the energy source is a pulsed laser. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT are also disclosed.Type: GrantFiled: August 17, 2016Date of Patent: September 5, 2017Assignee: PHOTON JET LTDInventor: Aryeh Batt
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Publication number: 20170043603Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir (9) comprising at least one opening; and an energy source configured to deliver energy to a donor material within said reservoir. In preferred embodiments of the invention, the energy source is a pulsed laser. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT are also disclosed.Type: ApplicationFiled: August 17, 2016Publication date: February 16, 2017Applicant: PHOTON JET LTDInventor: Aryeh BATT
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Patent number: 9446618Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir (9) comprising at least one opening; and an energy source configured to deliver energy to a donor material within said reservoir. In preferred embodiments of the invention, the energy source is a pulsed laser. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT are also disclosed.Type: GrantFiled: October 21, 2013Date of Patent: September 20, 2016Assignee: PHOTON JET LTDInventor: Aryeh Batt
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Publication number: 20160166353Abstract: The present invention provides an imaging system having an imaging device for imaging at least a portion of an animal; said imaging device selected from a group consisting of X-ray computed tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), fluorescence and phosphorescence microscopy (FPM) and any combination thereof; consisting of CT, computer-assisted tomography; IR, rendered images comprising infrared light spectroscopy; PET, positron emission tomography; fluorescence and phosphorescence microscopy, a Raman spectroscopic imaging system, ultrasound and any combination thereof.Type: ApplicationFiled: February 11, 2016Publication date: June 16, 2016Applicant: ASPECT IMAGING LTD.Inventors: Uri RAPOPORT, Aryeh BATT
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Publication number: 20160157720Abstract: The present invention provides a hybrid imaging system for imaging a volume of interest of a subject, said hybrid system is characterized by: a. a MRI device; b. a photon transmitter, introducible within the body of an animal; c. at least one imaging photon detector located either within or outside said animal, for detecting fluorescence excited within said animal by said transmitted photons; and d. an image processor adapted to superimpose said MRI image and said at least one photon detector image, generating a rendered MRI image of said volume of interest of the subject. The hybrid system is configured to substantially simultaneously acquire MRI image and in vivo fluorescence image.Type: ApplicationFiled: February 11, 2016Publication date: June 9, 2016Applicant: ASPECT IMAGING LTD.Inventors: Uri RAPOPORT, Aryeh BATT
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Publication number: 20150239274Abstract: A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir (9) comprising at least one opening; and an energy source configured to deliver energy to a donor material within said reservoir. In preferred embodiments of the invention, the energy source is a pulsed laser. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT are also disclosed.Type: ApplicationFiled: October 21, 2013Publication date: August 27, 2015Inventor: Aryeh Batt
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Publication number: 20140051976Abstract: An MRI apparatus that induces a magnetic resonance signal from an object to be imaged. The apparatus includes: magnet poles for creating a homogeneous magnetic field; and a set of RF coils for generating a radio frequency (RF) excitation pulse in the imaging volume of the apparatus, and for acquiring magnetic resonance signals resulting from the RF excitation pulse. The apparatus also includes a light-field (plenoptic) camera and the object may be imaged concurrently by both MRI and plenoptic channels. The obtained images can be superimposed.Type: ApplicationFiled: July 16, 2013Publication date: February 20, 2014Inventors: Uri RAPOPORT, Aryeh BATT
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Publication number: 20140051974Abstract: A magnetic resonance imaging (MRI) imaging system, including: an MRI device adapted to image at least a portion of an animal; a photon source; an imaging photon detector that detects photons emitted by the photon source; and an image processor that superimposes the MRI image and the photon detector image. The system also includes one or more polarizers located between the animal and the photon detector.Type: ApplicationFiled: July 16, 2013Publication date: February 20, 2014Inventors: Uri RAPOPORT, Aryeh BATT