Patents by Inventor Arzu SANDIKCI

Arzu SANDIKCI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complement factor I-related compositions and methods
    Patent number: 12116606
    Abstract: Provided herein are Complement Factor I (CFI) variants that exhibit at least one improved characteristic relative to a wild type CFI. CFI variants of the disclosure can exhibit tunable specificity and activity. Also included are CFI-containing fusion constructs comprising at least one domain of CFI, for example, wild type full length CFI fused to human serum albumin. Also included are methods of making and using such CFI variants and fusion constructs. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: October 15, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Grant E. Blouse, Brajesh Kumar, Tom Knudsen, Jan Kristian Jensen, Emil Oldenburg, Christine René Schar, Matthew John Traylor, Eric Steven Furfine, Jeffrey Charles Way, Agnieszka Jendroszek, Arzu Sandikci, Jim McGuire, Shyam Rajan Iyer, Natacha Le Moan
  • COMPLEMENT FACTOR I-RELATED COMPOSITIONS AND METHODS
    Publication number: 20230038638
    Abstract: Provided herein are Complement Factor I (CFI) variants that exhibit at least one improved characteristic relative to a wild type CFI. CFI variants of the disclosure can exhibit tunable specificity and activity. Also included are CFI-containing fusion constructs comprising at least one domain of CFI, for example, wild type full length CFI fused to human serum albumin. Also included are methods of making and using such CFI variants and fusion constructs. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.
    Type: Application
    Filed: June 14, 2021
    Publication date: February 9, 2023
    Inventors: Grant E. BLOUSE, Brajesh KUMAR, Tom KNUDSEN, Jan Kristian JENSEN, Emil OLDENBURG, Christine René SCHAR, Matthew John TRAYLOR, Eric Steven FURFINE, Jeffrey Charles WAY, Agnieszka JENDROSZEK, Arzu SANDIKCI, Jim MCGUIRE, Shyam Rajan IYER, Natacha LE MOAN