Abstract: A medicament having inhibitory activity against plasminogen activator inhibitor-1, which comprises as an active ingredient a compound represented by the following general formula (I) or a salt thereof: wherein R1 and R2 represents an aromatic group which may be substituted, W represents a group selected from the following connecting group W-1: (wherein a bond at the left end binds to the carbon atom and a bond at the right end binds to the nitrogen atom, X represents sulfur atom or NH, Y represents oxygen atom or sulfur atom, R3 represents a hydrocarbon group, hydroxy group, or carboxy group), Z represents a single bond or a connecting group wherein a number of atoms in a main chain is 1 to 3.

Abstract: A process for producing a 2-fluorocyclopropane-carboxylic acid of formula ?I! ##STR1## by reducing a 2-halo-2-fluorocyclopropanecarboxylic acid of formula ?II! ##STR2## the reduction being carried out by developing a Raney nickel alloy in the presence of the 2-halo-2-fluorocyclo-propanecarboxylic acid of formula ?II!, or by contacting the 2-halo-2-fluorocyclopropanecarboxylic acid of formula ?II! with hydrogen in an aqueous solvent using a Raney nickel catalyst.