Patents by Inventor Asako Murayama

Asako Murayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant replicon derived from genome of hepatitis C virus J6CF strain
    Patent number: 9186383
    Abstract: A nucleic acid includes the 5? untranslated region, a virus protein-coding region including the NS3 protein coding sequence, the NS4A protein coding sequence, the NS4B protein coding sequence, the NS5A protein coding sequence, and the NS5B protein coding sequence, and the 3? untranslated region of the HCV J6CF genome in that order from the 5? to 3? direction. The NS4A protein coding sequence has a mutation for substituting alanine at position 1680 with glutamic acid, as determined on the basis of the amino acid sequence of the precursor protein of the J6CF strain.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: November 17, 2015
    Assignees: Japan As Represented by Director-General of National Institute of Infectious Diseases, Toray Industries, Inc.
    Inventors: Takaji Wakita, Asako Murayama, Takanobu Kato
  • MUTANT REPLICON DERIVED FROM GENOME OF HEPATITIS C VIRUS J6CF STRAIN
    Publication number: 20140302092
    Abstract: A nucleic acid includes the 5? untranslated region, a virus protein-coding region including the NS3 protein coding sequence, the NS4A protein coding sequence, the NS4B protein coding sequence, the NS5A protein coding sequence, and the NS5B protein coding sequence, and the 3? untranslated region of the HCV J6CF genome in that order from the 5? to 3? direction. The NS4A protein coding sequence has a mutation for substituting alanine at position 1680 with glutamic acid, as determined on the basis of the amino acid sequence of the precursor protein of the J6CF strain.
    Type: Application
    Filed: May 31, 2012
    Publication date: October 9, 2014
    Applicants: Toray Industries, Inc., Japan as Represented by Director-General of National Institute of Infectious Diseases
    Inventors: Takaji Wakita, Asako Murayama, Takanobu Kato