Patents by Inventor Aser Rothstein

Aser Rothstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic peptide materials for joint reconstruction, repair and cushioning
    Patent number: 8119598
    Abstract: In joint reconstruction, repair and cushioning applications, a synthetic polypeptide material is useful that contains cross-linked polypeptides that are modeled on human elastin or other fibrous proteins. The polypeptides comprise at least three consecutive beta-sheet/beta-turn structures and at least one amino acid residue that participates in cross-linking.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: February 21, 2012
    Assignees: Hospital For Sick Children, Elastin Specialties, Inc.
    Inventors: Fred Keeley, Aser Rothstein, Steven Rothstein, Kimberly Woodhouse
  • Synthetic peptide materials for joint reconstruction, repair and cushioning
    Publication number: 20090075868
    Abstract: In joint reconstruction, repair and cushioning applications, a synthetic polypeptide material is useful that contains cross-linked polypeptides that are modeled on human elastin or other fibrous proteins. The polypeptides comprise at least three consecutive beta-sheet/beta-turn structures and at least one amino acid residue that participates in cross-linking.
    Type: Application
    Filed: May 6, 2008
    Publication date: March 19, 2009
    Inventors: Fred Keeley, Aser Rothstein, Steven Rothstein, Kimberly Woodhouse
  • Self-aligning peptides modeled on human elastin and other fibrous proteins
    Patent number: 6765086
    Abstract: A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 20, 2004
    Assignees: Protein Specialties, Ltd., HSC Research & Development Limited Partnership
    Inventors: Aser Rothstein, Fred Keeley, Steven Rothstein
  • Self-aligning peptides modeled on human elastin and other fibrous proteins
    Publication number: 20030166846
    Abstract: A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis.
    Type: Application
    Filed: September 28, 2001
    Publication date: September 4, 2003
    Inventors: Aser Rothstein, Fred Keeley, Steven Rothstein
  • Self-aligning peptides modeled on human elastin and other fibrous proteins
    Patent number: 6489446
    Abstract: A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: December 3, 2002
    Assignees: HSC Research and Development Limited Partnership, Protein Specialties, Ltd.
    Inventors: Aser Rothstein, Fred Keeley, Steven Rothstein
  • Self-aligning peptides modeled on human elastin and other fibrous proteins
    Patent number: 5969106
    Abstract: A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: October 19, 1999
    Assignees: The Hospital for Sick Children, Protein Specialties, Ltd.
    Inventors: Aser Rothstein, Fred W. Keely, Steven J. Rothstein
  • Use of antibody/antigen interactions to protect biologically active proteins and peptides
    Patent number: 5686579
    Abstract: A recombinant chimeric polypeptide is produced that contains a biologically active entity and a binding entity, that displays biologically active and is inactivation resistant. The biologically active entity corresponds, for example, to an enzyme and the binding entity corresponds, for example, to an antibody. The entities interact to form a structure analagous to an antibody-antigen complex. Thus, the inactivation-resistant complex displays prolonged activity under conditions characterized by disrupting temperature, the presence of a proteolytic enzyme, disrupting pH, the presence of an oxidizing agent and/or the presence of an alcohol, among others.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: November 11, 1997
    Assignee: Hybrisens, Ltd.
    Inventors: Ezekiel Y. Shami, Aser Rothstein, Mohabir Ramjeesingh