Patents by Inventor Asfandyar SIKANDAR

Asfandyar SIKANDAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene cluster for the biosynthetic production of tetracycline compounds in a heterologous host
    Publication number: 20200392071
    Abstract: The present invention relates to the application of biosynthetic engineering for the heterologous expression of a gene cluster for the biosynthesis of tetracycline compounds, notably chelocardin and its analogues. More particularly, the present invention pertains to a gene cluster encoding polypeptides involved in tetracycline biosynthesis, which gene cluster is suitable for heterologous expression of the biosynthetic pathway in a host cell. The present invention further pertains to DNA construct s comprising the gene cluster, to recombinant heterologous host cell s comprising the gene cluster or the DNA construct, to processes for the biosynthetic production of a tetracycline compound employing such recombinant host cells, and to tetracycline compounds thereby produced. The present invention also pertains to fusion proteins which are useful in the production of tetracycline compounds.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 17, 2020
    Inventors: Rolf MÜLLER, Tadeja LUKEZIC, Maja REMSKAR, Nestor ZABURANNYI, Chantal BADER, Asfandyar SIKANDAR, Jesko KÖHNKE