Patents by Inventor Asha Kulkarni-Almeida
Asha Kulkarni-Almeida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120225889Abstract: The present invention provides use of the compounds represented by formula (1): wherein, R1, R2, R3 and R4 are as defined in the specification, in all their stereo isomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable polymorphs and prodrugs and pharmaceutical compositions containing them for treatment of inflammatory disorders mediated by one or more cytokines selected from Tumor Necrosis Factor-alpha (TNF-?), interferon-? (IFN-?) and interleukins such as IL-1?, IL-2, IL-6, and IL-8. The present invention also relates to a pharmaceutical composition adapted for use in the treatment of inflammatory disorders. The present invention further provides a method of treatment of inflammatory disorders by administering a therapeutically effective amount of the said compound of formula (1) or its pharmaceutical composition, to a mammal in need thereof.Type: ApplicationFiled: November 15, 2010Publication date: September 6, 2012Applicant: PIRAMAL LIFE SCIENCES LIMITEDInventors: Asha Kulkarni-Almeida, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Prabha Beerchandra Mishra
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Patent number: 8206756Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: GrantFiled: July 9, 2009Date of Patent: June 26, 2012Assignee: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu
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Patent number: 8163730Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: GrantFiled: August 11, 2010Date of Patent: April 24, 2012Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Asha Kulkarni-Almeida, Sapna Parikh, Radha Bhaskar Panicker, Anagha Damre, Ravindra Gupte
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Patent number: 7964631Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: GrantFiled: August 11, 2010Date of Patent: June 21, 2011Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Pravin Gagare, Sunil Jadhav, Shashikant Patil, Asha Kulkarni-Almeida, Sapna Parikh, Radha Bhaskar Panicker, Anagha Damre, Ravindra Gupte
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Patent number: 7964628Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: GrantFiled: June 8, 2010Date of Patent: June 21, 2011Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V. S. V. Rao, Ravindra Dattatraya Gupte, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan, Radha Bhaskar Panicker, Eleanor Pinto De Souza
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Publication number: 20100324026Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R5 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: ApplicationFiled: August 11, 2010Publication date: December 23, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi LAL, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Pravin Gagare, Sunil Jadhav, Shashikant Patil, Asha Kulkarni-Almeida, Sapna Parikh, Radha Panicker, Anagha Damre, Ravindra Gupte
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Publication number: 20100305094Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: ApplicationFiled: August 11, 2010Publication date: December 2, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi Lal, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Asha Kulkarni-Almeida, Sapna Parikh, Radha Panicker, Anagha Damre, Ravindra Gupte
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Publication number: 20100256161Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: ApplicationFiled: June 8, 2010Publication date: October 7, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V.S.V Rao, Ravindra Dattatraya Gupte, Radha Bhaskar Panicker, Eleanor Pinto De Souza, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan
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Patent number: 7759387Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: GrantFiled: September 30, 2004Date of Patent: July 20, 2010Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V. S. V. Rao, Ravindra Dattatraya Gupte, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan, Radha Bhaskar Panicker, Eleanor Pinto De Souza
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Patent number: 7635494Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: GrantFiled: March 28, 2008Date of Patent: December 22, 2009Assignee: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu
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Publication number: 20090269427Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: ApplicationFiled: July 9, 2009Publication date: October 29, 2009Applicant: Piramal Life Sciences LimitedInventors: Vijay CHAUHAN, Ashish SUTHAR, Dhananjay SAPRE, Swati BAL-TEMBE, Ashok Kumar GANGOPADHYAY, Asha KULKARNI-ALMEIDA, Sapna Hasit PARIKH, Ravindra Dattatraya GUPTE, Nilesh Madhukar DAGIA, Somesh SHARMA, Shruta Sudheer DADARKAR, Mahesh Gundaji JADHAV, Aditi Amol TANNU
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Publication number: 20080254157Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: ApplicationFiled: March 28, 2008Publication date: October 16, 2008Applicant: PIRAMAL LIFE SCIENCES LIMITEDInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu
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Publication number: 20070299050Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: ApplicationFiled: November 8, 2005Publication date: December 27, 2007Applicant: Nicholas Piramal India Limited.Inventors: Bansi Lal, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Pravin Gagare, Sunil Jadhav, Shashikant Patil, Asha Kulkarni-Almeida, Sapna Parikh, Radha Panicker, Anagha Damre, Ravindra Gupte
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Publication number: 20070021489Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: ApplicationFiled: September 30, 2004Publication date: January 25, 2007Applicant: NICHOLAS PIRAMAL INDIA LIMITEDInventors: Bansi Lal, Ashok Gangopadhyay, Vadlamudi Rao, Ravindra Gupte, Gopal Gole, Asha Kulkarni-Almeida, Sridevi Krishnan, Radha Panicker, Eleanor Pinto De Souza