Patents by Inventor Asha Naidu

Asha Naidu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prevention and treatment of amyloid-associated disorders
    Publication number: 20020155426
    Abstract: The present invention provides a method of assaying for and arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing &bgr;-amyloid plaque burden by the administration of compounds that reduce apoE expression. The compounds used in the method of the invention may be: 1) inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase; 2) inhibitors of cholesterol biosynthesis; 3) inhibitors of protein isoprenylation, specifically geranylgeranylation; and/or 4) inhibitors of NF-&kgr;B activation or function. Assays for compounds with inhibit apoE expression from microglial cells are also disclosed.
    Type: Application
    Filed: June 14, 2002
    Publication date: October 24, 2002
    Inventors: Barbara Cordell, Qiang Xu, Asha Naidu, Steven M. Paul, Kelly R. Bales
  • Assay to identify compounds that alter apolipoprotein E expression
    Patent number: 6428950
    Abstract: The present invention provides a method of assaying for and arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing &bgr;-amyloid plaque burden by the administration of compounds that reduce apoE expression. The compounds used in the method of the invention may be: 1) inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase; 2) inhibitors of cholesterol biosynthesis; 3) inhibitors of protein isoprenylation, specifically geranylgeranylation; and/or 4) inhibitors of NF-&kgr;B activation or function. Assays for compounds with inhibit apoE expression from microglial cells are also disclosed.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: August 6, 2002
    Assignees: Scios Inc., Eli Lilly & Co.
    Inventors: Barbara Cordell, Qiang Xu, Asha Naidu, Steven M. Paul, Kelly R. Bales
  • Isolation and purification of lung surfactant protein
    Patent number: 5403915
    Abstract: Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C.sub.1 -C.sub.4 aliphatic alcohol and chromatographic purification steps which employ a C.sub.1 -C.sub.4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: April 4, 1995
    Assignee: Scios Nova Inc.
    Inventors: Bradley J. Benson, Douglas Buckley, David Lesikar, Asha Naidu, Kate B. Silverness
  • Isolation and purification of lung surfactant protein
    Patent number: 5258496
    Abstract: Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C.sub.1 -C.sub.4 aliphatic alcohol and chromatographic purification steps which employ a C.sub.1 -C.sub.4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: November 2, 1993
    Assignee: Scios Nova Inc.
    Inventors: Bradley J. Benson, Douglas Buckley, David Lesikar, Asha Naidu, Kate B. Silverness