Abstract: Systems and methods for encoding and decoding video content for machine consumption with enhanced region packing strategies. An encoder includes a region detector module which receives a source video and identifies regions of interest therein. A top-down region extractor module receives the identified regions of interest and generates modified set of regions of interest that can be packed in a frame more efficiently. A region packing module receives the modified set of regions of interest and arranges the modified set of regions of interest into a packed frame in which pixels outside the modified regions of interest are substantially excluded. A video encoder encodes the packed frame and region parameters into a coded bitstream. A decoder provides complimentary processing to reconstruct a frame with the regions of interest arranged as they were in the source frame.