Abstract: In some embodiments, the present disclosure provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. In some embodiments, the present disclosure provides a compound of Formula (II) as described herein, or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the compound of Formula (I) or Formula (II), and methods of treating cancer using the compound of Formula (I) or Formula (II) are also provided.

Abstract: The present invention includes a method of preparing apoptotic bodies from a tumour and immunogenic compositions thereof. The method of preparation comprises: obtaining human tumour cells from a subject, inducing apoptosis of the human tumour cells with a drug or a physical treatment, and collecting apoptotic bodies from the apoptotic human tumour cells by centrifugation. The method comprises two centrifugation steps, low-speed at 50 g for 5 minutes to pellet cells, followed by high-speed centrifugation of the obtained supernatant at 3,000 g for 8 minutes to pellet apoptotic bodies. The purity of the apoptotic bodies (also referred to as immunogenic Tumor Apoptotic Bodies (TABi)) was determined by FACS to be 82.22%.

Abstract: This document provides methods and materials involved in identifying mammals having blood cancer (e.g., myelomas or lymphomas, including WM, MCL, and DLBCL) that is resistant to treatment with a proteasome inhibitor such as bortezomib (e.g., VELCADE®) as well as methods and materials involved in treating mammals having a blood cancer resistant to a proteasome inhibitor such as bortezomib (e.g., VELCADE®). For example, methods and materials for using the expression level of PSMB9/?1i nucleic acid to identify a mammal as having a blood cancer (e.g., myeloma or lymphoma, such as WM, MCL, or DLBCL) that is resistant to treatment with a proteasome inhibitor such as bortezomib (e.g., VELCADE®) are provided.