Abstract: Devices, systems, and methods for closing the base of a left atrial appendage or other tissue structure comprise a device applicator having jaws, a shaft, and a handle. First and second triggers on a handle are configured to close the jaws and a closure device in a step-wise manner where tissue penetrating fasteners within the closure device are engaged by studs on the jaws, where the studs must be released prior to the opening of the jaws.

Abstract: Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.

Abstract: Devices, systems, and methods for closing the base of a left atrial appendage or other tissue structure comprise a device applicator having jaws, a shaft, and a handle. First and second triggers on a handle are configured to close the jaws and a closure device in a step-wise manner where tissue penetrating fasteners within the closure device are engaged by studs on the jaws, where the studs must be released prior to the opening of the jaws.

Abstract: An implantable occlusion and tissue ingrowth resistant fluid interface is provided with a housing, an orifice and a catheter port. The housing is formed from at least one biocompatible material and is configured without sharp edges or corners. The housing at least partially defines an internal housing cavity. The orifice member at least partially defines an orifice between the internal housing cavity and an exterior of the housing. The orifice has an elongated transverse cross-section configured with a length that is at least four times its maximum width. The catheter port is located on the housing and is configured to couple with a catheter such that the internal housing cavity is in fluid communication with a lumen of the catheter when the catheter is coupled to the catheter port. Embodiments having a moving cylinder, a rotor, and non-chemical surface modifications, as well as methods of use are also disclosed.

Abstract: Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.

Abstract: Devices, systems, and methods for closing the base of a left atrial appendage or other tissue structure comprise a device applicator having jaws, a shaft, and a handle. First and second triggers on a handle are configured to close the jaws and a closure device in a step-wise manner where tissue penetrating fasteners within the closure device are engaged by studs on the jaws, where the studs must be released prior to the opening of the jaws.

Abstract: Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.

Abstract: The present application describes an implant system useable for positioning an implant device such as a device useful for restricting passage of ingested food into the stomach. In one embodiment, the disclosed system includes a plurality of anchors that may be coupled to tissue within the stomach, or to a tissue tunnel formed by plicating stomach wall tissue. The anchor includes a loop. During use, the implant device is inserted through the loop and expanded such that it retains its position within the loop until removed. Instruments for implanting and explanting the implant device are also described.

Abstract: The present application describes an implant system useable for positioning an implant device such as a device useful for restricting passage of ingested food into the stomach. In one embodiment, the disclosed system includes a plurality of anchors that may be coupled to tissue within the stomach, or to a tissue tunnel formed by plicating stomach wall tissue. The anchor includes a loop. During use, the implant device is inserted through the loop and expanded such that it retains its position within the loop until removed. Instruments for implanting and explanting the implant device are also described.

Abstract: Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.

Abstract: Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.

Abstract: Devices, systems, and methods for closing the base of a left atrial appendage or other tissue structure comprise a device applicator having jaws, a shaft, and a handle. First and second triggers on a handle are configured to close the jaws and a closure device in a step-wise manner where tissue penetrating fasteners within the closure device are engaged by studs on the jaws, where the studs must be released prior to the opening of the jaws.

Abstract: A surgical ablation probe assembly particularly suitable for ablating tissue on a surface of a patient's heart having an ablation member and a stabilizing member for guiding the probe assembly to an intracorporeal location such as a surface of the patient's heart. The elongated ablation member generally has at least one ablation electrode on a distal shaft section. The stabilizing member has a vacuum lumen which applies a vacuum to the inner chamber of the stabilizing member to aspirate fluid from within the chamber or about the stabilizing member and can aid in holding the stabilizing member to an intracorporeal surface such as the epicardial or endocardial surface of the patient's heart. The probe assembly may also have a removable stylet to help retain the shape of the distal portion. The assembly is suitable for treating a patient for atrial arrhythmia, by forming linear or curvilinear lesions and preferably a continuous lesion on the surface of the patient's heart.

Abstract: A surgical ablation probe assembly particularly suitable for ablating tissue on a surface of a patient's heart having an ablation member and a stabilizing member for guiding the probe assembly to an intracorporeal location such as a surface of the patient's heart. The elongated ablation member generally has at least one ablation electrode on a distal shaft section. The stabilizing member has a vacuum lumen which applies a vacuum to the inner chamber of the stabilizing member to aspirate fluid from within the chamber or about the stabilizing member and can aid in holding the stabilizing member to an intracorporeal surface such as the epicardial or endocardial surface of the patient's heart. The probe assembly may also have a removable stylet to help retain the shape of the distal portion. The assembly is suitable for treating a patient for atrial arrhythmia, by forming linear or curvilinear lesions and preferably a continuous lesion on the surface of the patient's heart.

Abstract: The present application describes an implant system useable for positioning an implant device such as a device useful for restricting passage of ingested food into the stomach. In one embodiment, the disclosed system includes a plurality of anchors that may be coupled to tissue within the stomach, or to a tissue tunnel formed by plicating stomach wall tissue. The anchor includes a loop. During use, the implant device is inserted through the loop and expanded such that it retains its position within the loop until removed. Instruments for implanting and explanting the implant device are also described.

Abstract: Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.

Abstract: A surgical ablation probe assembly particularly suitable for ablating tissue on a surface of a patient's heart having an ablation member and a stabilizing member for guiding the probe assembly to an intracorporeal location such as a surface of the patient's heart. The elongated ablation member generally has at least one ablation electrode on a distal shaft section. The stabilizing member has a vacuum lumen which applies a vacuum to the inner chamber of the stabilizing member to aspirate fluid from within the chamber or about the stabilizing member and can aid in holding the stabilizing member to an intracorporeal surface such as the epicardial or endocardial surface of the patient's heart. The probe assembly may also have a removable stylet to help retain the shape of the distal portion. The assembly is suitable for treating a patient for atrial arrhythmia, by forming linear or curvilinear lesions and preferably a continuous lesion on the surface of the patient's heart.