Abstract: The present application discloses a method, system, and computer system for processing queries to sparsely populated datasets. The method includes (i) receiving a query from a client system, (ii) determining, based at least in part on the query, a plurality of partitions of a hypercube that are expected to comprise information used in generating a response for the query, (iii) communicating a set of requests to a data source storing the hypercube, the set of requests comprising one or more requests corresponding to the plurality of partitions of the hypercube, (iv) obtaining, from the data source, a set of results to the set of requests, the set of results comprising data stored in the plurality of partitions of the hypercube, (v) determining a plurality of virtual objects for the set of results, (vi) combining the plurality of virtual objects into a response to the query, and (vii) providing, to the client system, the response to the query.

Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.

Abstract: Various aspects of the disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for facilitating the exchange of data among a diverse group of first and third party computing environments. Accordingly, various aspects of the disclosure provide a data exchange computing platform that facilitates data exchange among a diverse group of first and third party computing environments. In some aspects, the data exchange computing platform provides a data exchange service available to various first and third parties who wish to exchange data.

Abstract: Various aspects of the disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for facilitating the exchange of data among a diverse group of first and third party computing environments. Accordingly, various aspects of the disclosure provide a data exchange computing platform that facilitates data exchange among a diverse group of first and third party computing environments. In some aspects, the data exchange computing platform provides a data exchange service available to various first and third parties who wish to exchange data.

Abstract: Various aspects of the disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for facilitating the exchange of data among a diverse group of first and third party computing environments. Accordingly, various aspects of the disclosure provide a data exchange computing platform that facilitates data exchange among a diverse group of first and third party computing environments. In some aspects, the data exchange computing platform provides a data exchange service available to various first and third parties who wish to exchange data.

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.

Abstract: The present disclosure discloses a herbal composition comprising herbal composition comprising a Vitex negundo aqueous leaf extract powder; a supercritical CO2 Zingiber officinale rhizome oleoresin; and pharmaceutical acceptable carrier wherein the ratio of Vitex negundo aqueous leaf extract powder to supercritical CO2 Zingiber officinale rhizome oleoresin to pharmaceutical acceptable carrier is in the range of 80:20:0 to 89:9:2. The present disclosure also discloses a process of preparation of a herbal composition. The present herbal composition is clinically proven effective for reducing acute or chronic musculoskeletal pain, alleviating physical-activity induced joint pain such as mechanical loads on joints, reducing exercise-induced knee joint pain and chronic non-specific low back pain and related dysfunction.

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.

Abstract: Dura shields in accordance with embodiments of the invention are disclosed. In one embodiment, a dura shield includes a shield configured to protect a patient's dura during an interbody procedure, a tether coupled to the shield and configured to position the shield, and an anchor coupled to the shield and configured to attach to a surface within the patient during the interbody procedure. A variety of sensors can be incorporated into the dura shield in order to monitor a patient during the procedure.

Abstract: Techniques for end-to-end Integration of disparate data systems in claims processing are provided. In one technique, in response to receiving first claim data: (1) a first record in a first data source is identified based on the first claim data; (2) a new record, that represents a claim, is generated in a second data source that is different than the first data source; and (3) a first portion of the first claim data is included in the new record. Second claim data that comprises one or more documents is received and the new record is updated with the second claim data. A third record in a third data source that is different than the first and second data sources is identified. A determination may be made whether any more documents are required for the new record. Based on the third record, it determined whether the claim will be fulfilled.

Abstract: Dura shields in accordance with embodiments of the invention are disclosed. In one embodiment, a dura shield includes a shield configured to protect a patient's dura during an interbody procedure, a tether coupled to the shield and configured to position the shield, and an anchor coupled to the shield and configured to attach to a surface within the patient during the interbody procedure. A variety of sensors can be incorporated into the dura shield in order to monitor a patient during the procedure.

Abstract: Techniques for providing strategic recommendations, links to actionable tasks, performance planning, and measurements in a workflow are provided. In one technique, electronic documents pertaining to multiple items that are managed by an online digital service are received. Based on processing the electronic documents, workflow data for the items are stored. The workflow data comprises multiple workflow data items, each indicating a status of a corresponding item of the multiple items. A request for item data associated with a particular item of the multiple items is received from a computing device. In response to receiving the request, the item data is retrieved and additional data that is generated by a computer system that is separate from the apparatus is retrieved. The additional data is one of descriptive data, prescriptive data, or predictive data. The item data and the additional data are presented simultaneously on a screen of the computing device.

Abstract: This disclosure relates generally to a system and method for using a machine-learning system to more accurately detect fraudulent use of credit cards on an e-commerce website and block those attempts.

Abstract: Some embodiments provide a novel method for receiving a plurality of attribute sets from a set of host computers, each attribute set associated with a group of one or more flows that is created by using a key to associate individual flows into the group of flows. The appliance, in some embodiments, merges two identified attribute sets into one merged attribute set and analyzes the merged attribute set to identify a set of properties of the flows in the groups of flows associated with the two attribute sets. In some embodiments, a visualization process includes identifying machines as members of groups and identifying machines that are connected. The visualization process, in some embodiments, also generates a graphical user interface that can be used to select groups of machines, domains, or individual machines and displays contextual attributes relevant to the selected group, domain, or machine.

Abstract: Some embodiments provide a novel method for collecting and reporting attributes of data flows associated with machines executing on a plurality of host computers to an analysis appliance and providing visual representations of the data to a user. Some embodiments provide a visual representation of the collected data that allows a user to select a set of machines and flows and initiate recommendation generation based on the selected machines and flows. The recommendation generation, in some embodiments, includes identifying flows for which rules have not been defined and filtering the identified rules to remove flows for which rules should not be defined. Some embodiments use the identified rues to identify services and groups associated with the rules and generate recommendations for rules, groups and services based on the identified flows, groups and services. The recommendations, in some embodiments, are implemented as a single PATCH API.

Abstract: Embodiments provide methods, and systems for cryptographic keys exchange where the method can include receiving, by a server system, a client public key being part of a client asymmetric key pair from a client device; sending, by the server system, a server public key being part of a server asymmetric key pair to the client device; generating, by the server system, a random value master key and sending the random value master key encrypted using the client public key to the client device; and generating, by the server system, an initial unique session key and sending the initial unique session key encrypted under the random value master key to the client device. A unique session key from the set of the unique session keys is used by the client device to encrypt a session data for transmission to the server system per session.

Abstract: Some embodiments provide a novel method for receiving a plurality of attribute sets from a set of host computers, each attribute set associated with a group of one or more flows that is created by using a key to associate individual flows into the group of flows. The appliance, in some embodiments, merges two identified attribute sets into one merged attribute set and analyzes the merged attribute set to identify a set of properties of the flows in the groups of flows associated with the two attribute sets. In some embodiments, a visualization process includes identifying machines as members of groups and identifying machines that are connected. The visualization process, in some embodiments, also generates a graphical user interface that can be used to select groups of machines, domains, or individual machines and displays contextual attributes relevant to the selected group, domain, or machine.

Abstract: Some embodiments provide a novel method for collecting and reporting attributes of data flows associated with machines executing on a plurality of host computers to an analysis appliance and providing visual representations of the data to a user. Some embodiments provide a visual representation of the collected data that allows a user to select a set of machines and flows and initiate recommendation generation based on the selected machines and flows. The recommendation generation, in some embodiments, includes identifying flows for which rules have not been defined and filtering the identified rules to remove flows for which rules should not be defined. Some embodiments use the identified rues to identify services and groups associated with the rules and generate recommendations for rules, groups and services based on the identified flows, groups and services. The recommendations, in some embodiments, are implemented as a single PATCH API.

Abstract: A waste management receptacle system for containment of odorous waste comprising a primary receptacle, comprising a base with vertically extending sidewalls forming an interior portion, a rim, and primary receptacle lid movable between an open and closed position. The system includes a secondary receptacle comprising a bottom with upstanding sidewalls forming a secondary interior, and a lid portion moveable between open and closed positions. A clamping member secures the secondary receptacle within the primary receptacle interior. The clamping member comprises a lateral member having ends with longitudinal members extending therefrom, and a fastening member disposed on a longitudinal member. The fastening member is movable between a disengaged and engaged position to secure the clamping member to the primary receptacle.

Abstract: Some embodiments provide a novel method for collecting and reporting attributes of data flows associated with machines executing on a plurality of host computers to an analysis appliance and providing visual representations of the data to a user. Some embodiments provide a visual representation of the collected data that allows a user to select a set of machines and flows and initiate recommendation generation based on the selected machines and flows. The recommendation generation, in some embodiments, includes identifying flows for which rules have not been defined and filtering the identified rules to remove flows for which rules should not be defined. Some embodiments use the identified rues to identify services and groups associated with the rules and generate recommendations for rules, groups and services based on the identified flows, groups and services. The recommendations, in some embodiments, are implemented as a single PATCH API.