Abstract: The invention provides systems, methods and computer program products for monitoring vascular perfusion in replanted tissue flaps. Specifically, the invention provides a non-invasive solution for monitoring of vascular perfusion at a site of tissue replantation, and that is capable of detecting problems in vascular perfusion and raising alarms in real times. The invention achieves the above function objectives by means of non-invasive sensors that continuously monitor selected parameters related to tissue condition. The monitored data parameters are used to determine a real time condition of replanted tissue.