Patents by Inventor Ashish Guha
Ashish Guha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938632Abstract: A method includes: compiling lower-resolution images, captured during a global scan cycle executed over a workpiece, into a virtual model; defining a nominal toolpath and a nominal target force for the workpiece based on a the virtual model; detecting a defect indicator on the workpiece based on the lower-resolution images; accessing a higher-resolution image captured during a local scan cycle over the defect indicator; characterizing the defect indicator as a defect reparable via material removal based on the higher-resolution image; defining a repair toolpath for the defect based on the virtual model; navigating a sanding head over the workpiece according to the repair toolpath to repair the defect; and, during a processing cycle: navigating the sanding head across the workpiece according to the nominal toolpath and deviating the sanding head from the nominal toolpath to maintain forces of the sanding head on the workpiece proximal the nominal target force.Type: GrantFiled: May 2, 2023Date of Patent: March 26, 2024Assignee: GrayMatter Robotics Inc.Inventors: Avadhoot Ahire, YiWei Chen, Rishav Guha, Satyandra K. Gupta, Ariyan M. Kabir, Ashish Kulkarni, Caesar Navarro, Sagar Panchal, Brual C. Shah
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Patent number: 11730708Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where the treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation of the alkaline agent to the enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? E ? C ? L ) .Type: GrantFiled: September 17, 2020Date of Patent: August 22, 2023Assignee: Evonik Operations GmbHInventors: Priyanka Haksar, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
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Publication number: 20230088952Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.Type: ApplicationFiled: November 11, 2022Publication date: March 23, 2023Applicant: Evonik Operations GmbHInventors: Vinay Jain, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
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Publication number: 20230048354Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the ICL, containing an enteric polymer. The relation of alkaline agent to enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? ECL ) . The ? ICL ? has ? a ? thickness ? of ? about ? 22 ? ? ? m ? or ? more .Type: ApplicationFiled: September 17, 2020Publication date: February 16, 2023Applicant: Evonik Operations GmbHInventors: Priyanka Haksar, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
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Publication number: 20230012981Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where the treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation of the alkaline agent to the enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? E ? C ? L ) .Type: ApplicationFiled: September 17, 2020Publication date: January 19, 2023Applicant: Evonik Operations GmbHInventors: Priyanka HAKSAR, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
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Publication number: 20230000780Abstract: A dosage form contains a) a core, containing a biologically active ingredient, which is stable to a degree of at least 95% at a pH of 3 for 2 hours at 22° C.; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation in percent of the alkaline agent in the ICL to the enteric polymer in the ECL is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? ? ECL ) .Type: ApplicationFiled: September 17, 2020Publication date: January 5, 2023Applicant: Evonik Operations GmbHInventors: Priyanka Haksar, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
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Patent number: 11523992Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.Type: GrantFiled: April 29, 2020Date of Patent: December 13, 2022Assignee: Evonik Operations GmbHInventors: Vinay Jain, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
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Publication number: 20220331254Abstract: A pellet contains a core, which contains one or more biologically active ingredients, and a coating layer on the core. The coating layer contains a mixture of a first polymer and a second polymer. The first polymer is a core-shell polymer, containing 50 to 90% by weight of a core, containing polymerized units of 60 to 80% by weight of ethyl acrylate and 20 to 40% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 40 to 60% by weight of ethyl acrylate and 40 to 60% by weight of methacrylic acid. The second polymer contains polymerized units of 40 to 60% by weight of methacrylic acid and 60 to 40% by weight of ethyl acrylate or methyl methacrylate. A Multi-Unit Pellet System (MUPS) contains a multitude of the pellets.Type: ApplicationFiled: July 1, 2022Publication date: October 20, 2022Applicant: Evonik Operations GmbHInventors: Ashish Guha, Shraddha Joshi, Aditi Poddar, Suresh Doke
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Publication number: 20220287345Abstract: The invention provides preparations comprising at least one polyunsaturated fatty acid salt for use in enhancing the solubility in aqueous media for a pharmaceutical or nutraceutical active ingredient in comparison to the pharmaceutical or nutraceutical active ingredient alone by at least 100%, preferably at least 300%. Moreover, a method for preparing a pharmaceutical or nutraceutical dosage form comprising at least one polyunsaturated fatty acid salt and at least one pharmaceutical or nutraceutical active ingredient is disclosed.Type: ApplicationFiled: August 7, 2020Publication date: September 15, 2022Applicant: Evonik Operations GmbHInventors: Ashish GUHA, Sonam SINGH, Shraddha JOSHI, Peter NIEPOTH, Kathrin NOLLENBERGER, Prajakta SURVE, Priyanka HAKSAR
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Publication number: 20220287979Abstract: The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a. preparing a lubricant consisting of at least one polyunsaturated fatty acid salt; b. adding the lubricant and ingredients for the solid dosage form to a mixer; c. optionally carrying out one or more of the following steps: granulation, drying and sizing, d. blending the contents of the mixer; and e. compressing or slugging the blended contents to produce a solid dosage form. Solid dosage forms prepared according to this method and the use of PUFA salts as lubricant in tableting applications for compression of solid components are further comprised by the present invention.Type: ApplicationFiled: August 7, 2020Publication date: September 15, 2022Applicant: Evonik Operations GmbHInventors: Ashish GUHA, Vinay JAIN, Shraddha JOSHI, Theresia KUNTZ, Christian MAHLMEISTER, Jean-Luc HERBEAUX
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Publication number: 20220280388Abstract: The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a) preparing a binder consisting of at least one polyunsaturated fatty acid salt; b) adding the binder and ingredients for the solid dosage form to a mixer; c) optionally carrying out one or more of the following steps: granulation, drying and sizing, d) blending the contents of the mixer; and e) compressing or slugging the blended contents to produce a solid dosage form wherein the binding parameter (BP) for the solid dosage form is at least 2 and is determined by: BP=H/C, wherein H is the tablet breaking force in Newton (N) and C is the compression force in kilo Newton (kN). Solid dosage forms prepared according to this method and the use of PUFA salts as binder in tableting applications for compression of solid components are further comprised by the present invention.Type: ApplicationFiled: August 7, 2020Publication date: September 8, 2022Applicant: Evonik Operations GmbHInventors: Ashish GUHA, Vinay JAIN, Shraddha JOSHI, Jean-Luc HERBEAUX
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Publication number: 20220280387Abstract: The invention provides an improved down streaming process for production of polyunsaturated fatty acid salts suitable for tableting by direct compression.Type: ApplicationFiled: August 7, 2020Publication date: September 8, 2022Applicant: Evonik Operations GmbHInventors: Ashish GUHA, Theresia KUNTZ, Andreas EMRICH, Christian MAHLMEISTER, Johanna PETERS, Milan LATINOVIC (Deceased), Günter KNAUP, Joerg LOTZ, Thomas DIEHL, Vinay JAIN, Eduard HARTMANN
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Publication number: 20220257517Abstract: A powder composition contains 50 to 95% by weight of a copolymer mixture A of a copolymer 1 and a copolymer 2, and 50 to 5% by weight of a water-soluble cellulose B. The copolymer 1 contains 5 to 60% by weight of polymerized units of methacrylic acid and 95 to 40% by weight of C1- to C4-alkylesters of (meth)acrylic acid. The copolymer 2 contains more than 95 and up to 100% by weight of polymerized units of C1- to C4-alkylesters of (meth)acrylic acid. The powder composition originates from the co-processing of the copolymer mixture A and the water-soluble cellulose B by a drying process of an aqueous dispersion, such as spray drying or freeze drying. Further processing leads to a compressed dosage form.Type: ApplicationFiled: June 8, 2020Publication date: August 18, 2022Applicant: Evonik Operations GmbHInventors: Ashish Guha, Sonam Singh, Suresh Doke, Shraddha Joshi, Manfred Aßmus, Jitendra Amrutkar
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Patent number: 11406599Abstract: A pellet contains a core, which contains one or more biologically active ingredients, and a coating layer on the core. The coating layer contains a mixture of a first polymer and a second polymer. The first polymer is a core-shell polymer, containing 50 to 90% by weight of a core, containing polymerized units of 60 to 85% by weight of ethyl acrylate and 20 to 40% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 40 to 60% by weight ethyl acrylate and 40 to 60% by weight methacrylic acid. The second polymer contains polymerized units of 40 to 60% by weight of methacrylic acid and 60 to 40% by weight of ethyl acrylate or methyl methacrylate. A Multi-Unit Pellet System (MUPS), preferably a compressed tablet, contains a multitude of the pellets.Type: GrantFiled: March 26, 2020Date of Patent: August 9, 2022Assignee: Evonik Operations GmbHInventors: Ashish Guha, Shraddha Joshi, Aditi Poddar, Suresh Doke
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Publication number: 20220241155Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.Type: ApplicationFiled: April 30, 2020Publication date: August 4, 2022Applicant: Evonik Operations GmbHInventors: Vinay JAIN, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
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Publication number: 20220142930Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.Type: ApplicationFiled: April 29, 2020Publication date: May 12, 2022Applicant: Evonik Operations GmbHInventors: Vinay JAIN, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
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Publication number: 20220142928Abstract: A pellet contains a core, which contains one or more biologically active ingredients, and a coating layer on the core. The coating layer contains a mixture of a first polymer and a second polymer. The first polymer is a core-shell polymer, containing 50 to 90% by weight of a core, containing polymerized units of 60 to 85% by weight of ethyl acrylate and 20 to 40 % by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 40 to 60% by weight ethyl acrylate and 40 to 60% by weight methacrylic acid. The second polymer contains polymerized units of 40 to 60% by weight of methacrylic acid and 60 to 40% by weight of ethyl acrylate or methyl methacrylate. A Multi-Unit Pellet System (MUPS), preferably a compressed tablet, contains a multitude of the pellets.Type: ApplicationFiled: March 26, 2020Publication date: May 12, 2022Applicant: Evonik Operations GmbHInventors: Ashish GUHA, Shraddha Joshi, Aditi Poddar, Suresh Doke
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Publication number: 20210361585Abstract: A process prepares a polymer-coated hard shell capsule, suitable as container for pharmaceutical or nutraceutical biologically active ingredients. The hard shell capsule can include a body and a cap. In the closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The hard shell capsule can be provided in the pre-locked state and spray-coated with a coating solution, suspension, or dispersion that includes a polymer or a mixture of polymers to create a coating layer which covers the outer surface of the hard shell capsule in the pre-locked state.Type: ApplicationFiled: November 14, 2018Publication date: November 25, 2021Applicant: Evonik Operations GmbHInventors: Ashish Guha, Vishal Kaneria, Vinay Jain, Shradda Joshi, Miriam Robota, Felix Hofmann, Marcel Arndt, Hans Bär
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Publication number: 20210205230Abstract: The invention refers to a pharmaceutical or nutraceutical composition comprising a core a) comprising an active ingredient and a water-insoluble polymer, a coating layer b) above the core a) comprising a salt of an alginic acid, and a coating layer c) above the coating layer b) comprising an anionic (meth)acrylate copolymer polymerized from a (meth)acrylate monomer mixture comprising 5-75% by weight in relation to the total weigh of the (meth)acrylate monomer mixture of (meth)acrylate monomers with an anionic group, wherein the amount of the water-insoluble polymer in the core a) is 2 to 20% by weight in relation to the weight of the corm a) and the amount of the salt of an alginic acid in the coating layer b) is 5 to 85% by weight in relation to the weight of the core a) and the amount of the anionic (meth)acrylate copolymer in the coaling layer c) is 10 to 75% by weight in relation to the weight of the care a) and to the coating layer b).Type: ApplicationFiled: March 16, 2021Publication date: July 8, 2021Applicant: Evonik Operations GmbHInventors: Shraddha Joshi, Ashish Guha, Sanjay Lanke, Vinay Jain, Firouz Asgarzadeh, Mitulkumar Patel
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Patent number: 10980751Abstract: The invention refers to a pharmaceutical or nutraceutical composition comprising a core a) comprising an active ingredient and a water-insoluble polymer, a coating layer b) above the core a) comprising a salt of an alginic acid, and a coating layer c) above the coating layer b) comprising an anionic (meth)acrylate copolymer polymerized from a (meth)acrylate monomer mixture comprising 5-75% by weight in relation to the total weight of the (meth)acrylate monomer mixture of (meth)acrylate monomers with an anionic group, wherein the amount of the water-insoluble polymer in the core a) is 2 to 20% by weight in relation to the weight of the core a) and the amount of the salt of an alginic acid in the coating layer b) is 5 to 85% by weight in relation to the weight of the core a) and the amount of the anionic (meth)acrylate copolymer in the coating layer c) is 10 to 75% by weight in relation to the weight of the core a) and to the coating layer b).Type: GrantFiled: May 23, 2016Date of Patent: April 20, 2021Assignee: Evonik Operations GmbHInventors: Shraddha Joshi, Ashish Guha, Sanjay Lanke, Vinay Jain, Firouz Asgarzadeh, Mitulkumar M Patel