Patents by Inventor Ashish Guha

Ashish Guha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11938632
    Abstract: A method includes: compiling lower-resolution images, captured during a global scan cycle executed over a workpiece, into a virtual model; defining a nominal toolpath and a nominal target force for the workpiece based on a the virtual model; detecting a defect indicator on the workpiece based on the lower-resolution images; accessing a higher-resolution image captured during a local scan cycle over the defect indicator; characterizing the defect indicator as a defect reparable via material removal based on the higher-resolution image; defining a repair toolpath for the defect based on the virtual model; navigating a sanding head over the workpiece according to the repair toolpath to repair the defect; and, during a processing cycle: navigating the sanding head across the workpiece according to the nominal toolpath and deviating the sanding head from the nominal toolpath to maintain forces of the sanding head on the workpiece proximal the nominal target force.
    Type: Grant
    Filed: May 2, 2023
    Date of Patent: March 26, 2024
    Assignee: GrayMatter Robotics Inc.
    Inventors: Avadhoot Ahire, YiWei Chen, Rishav Guha, Satyandra K. Gupta, Ariyan M. Kabir, Ashish Kulkarni, Caesar Navarro, Sagar Panchal, Brual C. Shah
  • Patent number: 11730708
    Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where the treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation of the alkaline agent to the enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? E ? C ? L ) .
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: August 22, 2023
    Assignee: Evonik Operations GmbH
    Inventors: Priyanka Haksar, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
  • Publication number: 20230088952
    Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.
    Type: Application
    Filed: November 11, 2022
    Publication date: March 23, 2023
    Applicant: Evonik Operations GmbH
    Inventors: Vinay Jain, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
  • Publication number: 20230048354
    Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the ICL, containing an enteric polymer. The relation of alkaline agent to enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? ECL ) . The ? ICL ? has ? a ? thickness ? of ? about ? 22 ? ? ? m ? or ? more .
    Type: Application
    Filed: September 17, 2020
    Publication date: February 16, 2023
    Applicant: Evonik Operations GmbH
    Inventors: Priyanka Haksar, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
  • Publication number: 20230012981
    Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where the treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation of the alkaline agent to the enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? E ? C ? L ) .
    Type: Application
    Filed: September 17, 2020
    Publication date: January 19, 2023
    Applicant: Evonik Operations GmbH
    Inventors: Priyanka HAKSAR, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
  • Publication number: 20230000780
    Abstract: A dosage form contains a) a core, containing a biologically active ingredient, which is stable to a degree of at least 95% at a pH of 3 for 2 hours at 22° C.; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation in percent of the alkaline agent in the ICL to the enteric polymer in the ECL is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? ? ECL ) .
    Type: Application
    Filed: September 17, 2020
    Publication date: January 5, 2023
    Applicant: Evonik Operations GmbH
    Inventors: Priyanka Haksar, Shraddha Joshi, Umesh Kapale, Nilam Bharambe, Ashish Guha, Vinay Jain
  • Patent number: 11523992
    Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: December 13, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Vinay Jain, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
  • Publication number: 20220331254
    Abstract: A pellet contains a core, which contains one or more biologically active ingredients, and a coating layer on the core. The coating layer contains a mixture of a first polymer and a second polymer. The first polymer is a core-shell polymer, containing 50 to 90% by weight of a core, containing polymerized units of 60 to 80% by weight of ethyl acrylate and 20 to 40% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 40 to 60% by weight of ethyl acrylate and 40 to 60% by weight of methacrylic acid. The second polymer contains polymerized units of 40 to 60% by weight of methacrylic acid and 60 to 40% by weight of ethyl acrylate or methyl methacrylate. A Multi-Unit Pellet System (MUPS) contains a multitude of the pellets.
    Type: Application
    Filed: July 1, 2022
    Publication date: October 20, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish Guha, Shraddha Joshi, Aditi Poddar, Suresh Doke
  • Publication number: 20220287345
    Abstract: The invention provides preparations comprising at least one polyunsaturated fatty acid salt for use in enhancing the solubility in aqueous media for a pharmaceutical or nutraceutical active ingredient in comparison to the pharmaceutical or nutraceutical active ingredient alone by at least 100%, preferably at least 300%. Moreover, a method for preparing a pharmaceutical or nutraceutical dosage form comprising at least one polyunsaturated fatty acid salt and at least one pharmaceutical or nutraceutical active ingredient is disclosed.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 15, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish GUHA, Sonam SINGH, Shraddha JOSHI, Peter NIEPOTH, Kathrin NOLLENBERGER, Prajakta SURVE, Priyanka HAKSAR
  • Publication number: 20220287979
    Abstract: The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a. preparing a lubricant consisting of at least one polyunsaturated fatty acid salt; b. adding the lubricant and ingredients for the solid dosage form to a mixer; c. optionally carrying out one or more of the following steps: granulation, drying and sizing, d. blending the contents of the mixer; and e. compressing or slugging the blended contents to produce a solid dosage form. Solid dosage forms prepared according to this method and the use of PUFA salts as lubricant in tableting applications for compression of solid components are further comprised by the present invention.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 15, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish GUHA, Vinay JAIN, Shraddha JOSHI, Theresia KUNTZ, Christian MAHLMEISTER, Jean-Luc HERBEAUX
  • Publication number: 20220280388
    Abstract: The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a) preparing a binder consisting of at least one polyunsaturated fatty acid salt; b) adding the binder and ingredients for the solid dosage form to a mixer; c) optionally carrying out one or more of the following steps: granulation, drying and sizing, d) blending the contents of the mixer; and e) compressing or slugging the blended contents to produce a solid dosage form wherein the binding parameter (BP) for the solid dosage form is at least 2 and is determined by: BP=H/C, wherein H is the tablet breaking force in Newton (N) and C is the compression force in kilo Newton (kN). Solid dosage forms prepared according to this method and the use of PUFA salts as binder in tableting applications for compression of solid components are further comprised by the present invention.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 8, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish GUHA, Vinay JAIN, Shraddha JOSHI, Jean-Luc HERBEAUX
  • Publication number: 20220280387
    Abstract: The invention provides an improved down streaming process for production of polyunsaturated fatty acid salts suitable for tableting by direct compression.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 8, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish GUHA, Theresia KUNTZ, Andreas EMRICH, Christian MAHLMEISTER, Johanna PETERS, Milan LATINOVIC (Deceased), Günter KNAUP, Joerg LOTZ, Thomas DIEHL, Vinay JAIN, Eduard HARTMANN
  • Publication number: 20220257517
    Abstract: A powder composition contains 50 to 95% by weight of a copolymer mixture A of a copolymer 1 and a copolymer 2, and 50 to 5% by weight of a water-soluble cellulose B. The copolymer 1 contains 5 to 60% by weight of polymerized units of methacrylic acid and 95 to 40% by weight of C1- to C4-alkylesters of (meth)acrylic acid. The copolymer 2 contains more than 95 and up to 100% by weight of polymerized units of C1- to C4-alkylesters of (meth)acrylic acid. The powder composition originates from the co-processing of the copolymer mixture A and the water-soluble cellulose B by a drying process of an aqueous dispersion, such as spray drying or freeze drying. Further processing leads to a compressed dosage form.
    Type: Application
    Filed: June 8, 2020
    Publication date: August 18, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish Guha, Sonam Singh, Suresh Doke, Shraddha Joshi, Manfred Aßmus, Jitendra Amrutkar
  • Patent number: 11406599
    Abstract: A pellet contains a core, which contains one or more biologically active ingredients, and a coating layer on the core. The coating layer contains a mixture of a first polymer and a second polymer. The first polymer is a core-shell polymer, containing 50 to 90% by weight of a core, containing polymerized units of 60 to 85% by weight of ethyl acrylate and 20 to 40% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 40 to 60% by weight ethyl acrylate and 40 to 60% by weight methacrylic acid. The second polymer contains polymerized units of 40 to 60% by weight of methacrylic acid and 60 to 40% by weight of ethyl acrylate or methyl methacrylate. A Multi-Unit Pellet System (MUPS), preferably a compressed tablet, contains a multitude of the pellets.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 9, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Ashish Guha, Shraddha Joshi, Aditi Poddar, Suresh Doke
  • Publication number: 20220241155
    Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.
    Type: Application
    Filed: April 30, 2020
    Publication date: August 4, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Vinay JAIN, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
  • Publication number: 20220142930
    Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.
    Type: Application
    Filed: April 29, 2020
    Publication date: May 12, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Vinay JAIN, Ashish Guha, Shraddha Joshi, Felix Hofmann, Bettina Hölzer, Hans Bär
  • Publication number: 20220142928
    Abstract: A pellet contains a core, which contains one or more biologically active ingredients, and a coating layer on the core. The coating layer contains a mixture of a first polymer and a second polymer. The first polymer is a core-shell polymer, containing 50 to 90% by weight of a core, containing polymerized units of 60 to 85% by weight of ethyl acrylate and 20 to 40 % by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 40 to 60% by weight ethyl acrylate and 40 to 60% by weight methacrylic acid. The second polymer contains polymerized units of 40 to 60% by weight of methacrylic acid and 60 to 40% by weight of ethyl acrylate or methyl methacrylate. A Multi-Unit Pellet System (MUPS), preferably a compressed tablet, contains a multitude of the pellets.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 12, 2022
    Applicant: Evonik Operations GmbH
    Inventors: Ashish GUHA, Shraddha Joshi, Aditi Poddar, Suresh Doke
  • Publication number: 20210361585
    Abstract: A process prepares a polymer-coated hard shell capsule, suitable as container for pharmaceutical or nutraceutical biologically active ingredients. The hard shell capsule can include a body and a cap. In the closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The hard shell capsule can be provided in the pre-locked state and spray-coated with a coating solution, suspension, or dispersion that includes a polymer or a mixture of polymers to create a coating layer which covers the outer surface of the hard shell capsule in the pre-locked state.
    Type: Application
    Filed: November 14, 2018
    Publication date: November 25, 2021
    Applicant: Evonik Operations GmbH
    Inventors: Ashish Guha, Vishal Kaneria, Vinay Jain, Shradda Joshi, Miriam Robota, Felix Hofmann, Marcel Arndt, Hans Bär
  • Publication number: 20210205230
    Abstract: The invention refers to a pharmaceutical or nutraceutical composition comprising a core a) comprising an active ingredient and a water-insoluble polymer, a coating layer b) above the core a) comprising a salt of an alginic acid, and a coating layer c) above the coating layer b) comprising an anionic (meth)acrylate copolymer polymerized from a (meth)acrylate monomer mixture comprising 5-75% by weight in relation to the total weigh of the (meth)acrylate monomer mixture of (meth)acrylate monomers with an anionic group, wherein the amount of the water-insoluble polymer in the core a) is 2 to 20% by weight in relation to the weight of the corm a) and the amount of the salt of an alginic acid in the coating layer b) is 5 to 85% by weight in relation to the weight of the core a) and the amount of the anionic (meth)acrylate copolymer in the coaling layer c) is 10 to 75% by weight in relation to the weight of the care a) and to the coating layer b).
    Type: Application
    Filed: March 16, 2021
    Publication date: July 8, 2021
    Applicant: Evonik Operations GmbH
    Inventors: Shraddha Joshi, Ashish Guha, Sanjay Lanke, Vinay Jain, Firouz Asgarzadeh, Mitulkumar Patel
  • Patent number: 10980751
    Abstract: The invention refers to a pharmaceutical or nutraceutical composition comprising a core a) comprising an active ingredient and a water-insoluble polymer, a coating layer b) above the core a) comprising a salt of an alginic acid, and a coating layer c) above the coating layer b) comprising an anionic (meth)acrylate copolymer polymerized from a (meth)acrylate monomer mixture comprising 5-75% by weight in relation to the total weight of the (meth)acrylate monomer mixture of (meth)acrylate monomers with an anionic group, wherein the amount of the water-insoluble polymer in the core a) is 2 to 20% by weight in relation to the weight of the core a) and the amount of the salt of an alginic acid in the coating layer b) is 5 to 85% by weight in relation to the weight of the core a) and the amount of the anionic (meth)acrylate copolymer in the coating layer c) is 10 to 75% by weight in relation to the weight of the core a) and to the coating layer b).
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: April 20, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Shraddha Joshi, Ashish Guha, Sanjay Lanke, Vinay Jain, Firouz Asgarzadeh, Mitulkumar M Patel