Abstract: Methods and apparatus for scaling in bioprocess systems are disclosed. An example apparatus for bioprocess scaling includes at least one memory to store instructions, and processor circuitry to execute the instructions to identify an operating parameter of a target bioreactor, determine an upper boundary or a lower boundary defining a design space for at least one bioreactor process parameter to match at least one of a first target parameter range or a second target parameter range based on the operating parameter, simulate changes in the first target parameter range or a second target parameter range based on an adjustment to the upper boundary or the lower boundary in the design space, and configure the target bioreactor using output obtained from the adjustment to the upper boundary or the lower boundary to identify a match between the first target parameter range or the second target parameter range.

Abstract: Various methods and systems are provided for dynamically adjusting user guidance based on a user's proficiency by tracking the same. In one example, a proficiency score for a user may be tracked over time and practice based on a pre-defined rubric for a given anatomical region and a given anatomical target within the anatomical region. During medical imaging, based on the proficiency score of the user, an amount of user guidance that is provided to the user may be adjusted. For example, user guidance may be automatically activated to guide the user during the imaging procedure when the proficiency score of the user is less than a threshold score.