Abstract: The present invention relates to stable injectable compositions comprising meloxicam or its pharmaceutically acceptable salts, solvates, or hydrates thereof, wherein the composition is provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe. Further, the present invention relates to a stable injectable solution comprising meloxicam or its pharmaceutically acceptable salts, solvates, or hydrates thereof, suitable for subcutaneous, intravenous or intramuscular administration. The invention relates to methods for manufacturing stable injectable solutions of meloxicam. The present invention further relates to a method of treating pain by parenterally administering to a patient in need thereof a composition comprising a stable solution of meloxicam, wherein said solution provides rapid onset of action for pain relief compared to a reference composition.

Abstract: Systems, methods, and computer readable storage medium are described for media presentation device or microphone calibration via event detection. An adjustment event is detected based on an analysis of a received signal. A determination to adjust at least one of a volume setting of a media presentation device or a gain setting of a microphone is made based at least on the detected adjustment event. Responsive to the determination, a first command is transmitted to at least one of the media presentation device or the microphone. In an aspect, the received signal is an audio data signal received from a listening device. In another aspect, the received signal is a command signal received from a second computing device via a network interface, the command signal comprising instructions to adjust the volume setting of the media presentation device, the second computing device remotely located and associated with a second user.

Abstract: A system (102) for assisting a patient to raise an alarm is disclosed. The system (102) may include a sensor (106) configured to be positioned at a head region of the patient and to detect movement of head of the patient. The system (102) may further include a patient assisting device (104) coupled to the sensor (106). The patient assisting device (104) may be configured to receive, from the sensor (106), a signal corresponding to the movement of the head of the patient, determine a state of alarm value from the signal, and generate an alarm based on the state of alarm value.

Abstract: Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: Aspects of the disclosure relate to a dynamic caching platform. The dynamic caching platform may train a machine learning model based on historical complexity score information. The dynamic caching platform may receive information streams from a client metaverse device and a metaverse host system. The dynamic caching platform may generate a complexity score based on the interaction information streams using the machine learning model. The dynamic caching platform may compare the complexity score to complexity thresholds. Based on the comparison, the dynamic caching platform may identify caching rules. The dynamic caching platform may cache interaction information based on the caching rules. The dynamic caching platform may update the complexity score using the machine learning model. The dynamic caching platform may update the caching rules based on the updated complexity score. The dynamic caching platform may cache interaction information based on the updated caching rules.

Abstract: A technique provides efficient data failover by creation and deployment of a protection policy that ensures maintenance of frequent common snapshots between sites of a multi-site data replication environment. A global constraint optimizer executes on a node of a cluster to create the protection policy for deployment among other nodes of clusters at the sites. Constraints such as protection rules (PRs) specifying, e.g., an amount of tolerable data loss are applied to a category of data designated for failover from a primary site over a network to a plurality of (secondary and tertiary) sites typically located at geographically separated distances. The optimizer processes the PRs to compute parameters such as frequency of snapshot generation and replication among the sites, as well as retention of the latest common snapshot maintained at each site to create a recovery point and configuration of the protection policy that reduces network traffic for efficient use of the network among the sites.

Abstract: Disclosed are techniques for multi-protocol multi-site file replication, including a method comprising capturing, at a gateway device, IO operations performed on a filesystem, the filesystem having inode bits. The method may further comprise enqueuing the captured IO operations onto a plurality of queues, wherein each of the plurality of queues is associated with one of a plurality of target sites; and independently managing replication of the IO operations to the target sites using the inode bits.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instruction that, when executed on the one or more processors, cause the one or more processors to perform operations: generating, using a training procedure, labels based at least in part on price band activity data from a time period; training, using the training procedure, an affinity prediction model of a machine learning architecture; analyzing, using the affinity prediction model of the machine learning architecture, as trained, the price band activity data indicating interactions of a user with items; and generating, using the labels and the affinity prediction model of the machine learning architecture, as trained, one or more price affinity predictions for one or more items for the user. Other embodiments are disclosed herein.

Abstract: The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or ?-? unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Abstract: A method and system for cloud based service provider performance evaluation are disclosed. The method may include extracting service record data and ticket status change record data from the service ticket data and aggregating the service record data and the ticket status change record data. The method may include calculating ticket level performance metric data based on the aggregated record data and generating ticket level performance scores based on the ticket level performance metric data. The method may further include generating service level performance scores based on the service level performance metric data and generating service feedback performance scores based on the service feedback metric data. The method may further include merging the ticket level performance scores, the service level performance scores, and the service feedback performance scores to generate performance vectors and evaluating overall performances of the service providers based on the set of performance vectors.

Abstract: Various devices, such as storage devices or systems are configured to efficiently manage and determine control table sets. Such a device may include a processor, a memory array including a plurality of memory devices which include a plurality of control table sets stored in a plurality of regions, and a control table set determination logic configured to: receive a command from a host device associated with logical to physical address mapping updates, determine a control table set of the plurality of control table sets associated with the command, determine a region of the plurality of regions associated with the determined control table set, determine a position in the control table set in the determined region associated with the command, generate additional control table sets upon a first determination that the position is not vacant, and store the command in the generated additional control table sets.

Abstract: Deriving augmented knowledge defining a knowledge base by extracting entities from a plurality of heterogeneous data sources; and augmenting the extracted entities; and utilizing an augmented entity to enhance a user activity.

Abstract: Disclosed are various embodiments for a service for decentralized browser based wallets. Various embodiments of the present disclosure can receive a first passcode and a second passcode from a security provider device. Various embodiments can use a cryptowallet to decrypt a first encrypted private key using the first passcode to generate a decrypted private key. Various embodiments can use a cryptowallet to sign a transaction request with the decrypted private key. Various embodiments can use a cryptowallet to generate a second encrypted private key by encrypting the decrypted private key using the second passcode.

Abstract: Stable, ready-to-use injectable pharmaceutical compositions are provided, comprising the combination of neostigmine, glycopyrrolate, and a pharmaceutically acceptable liquid vehicle, optionally with additional pharmaceutically acceptable excipients. Other aspects of the invention relate to methods for making such compositions and methods of using such compositions for reversing the effects of non-depolarizing neuromuscular blocking agents. Preferably, the composition comprises neostigmine methylsulfate, glycopyrronium bromide, and a pharmaceutically acceptable liquid vehicle, and is provided in a pre-filled, ready-to-use sealed container, such as a pre-filled syringe, suitable for intravenous administration.

Abstract: Techniques for granting, for a device, access to additional functionality requested by user inputs received by the device are described. A system may receive, from a device, a first user input requesting content of a content type requiring additional functionality access in order for the content to be sent to the device. The system may exchange data with an access control system in order to determine the device is capable of performing the additional functionality. The system may prompt the user as to whether the additional functionality access should be granted. In response to receiving a confirmatory user input, the system may cause the access control system to grant the additional functionality access for the device.

Abstract: A method performed by a multi-subscriber identity module (MUSIM) user equipment (UE) for continuing operation of the MUSIM UE in a first mode, the MUSIM UE including a first SIM and a second SIM, and the method including transmitting, by the MUSIM UE, an uplink signalling message in response to determining a trigger condition has been satisfied, the uplink signalling message including one of compatible band information for the first SIM and the SIM, or one or more other stacks serving band information associated with the second SIM, receiving, by the MUSIM UE from a network, a radio resource control (RRC) reconfiguration signalling message for performing at least one activity at the first SIM in response to the transmitting the uplink signalling message, and performing, by the MUSIM UE, the at least one activity based on the RRC reconfiguration signalling message.

Abstract: Techniques and mechanisms are disclosed to optimize the size of index files to improve use of storage space available to indexers and other components of a data intake and query system. Index files of a data intake and query system may include, among other data, a keyword portion containing mappings between keywords and location references to event data containing the keywords. Optimizing an amount of storage space used by index files may include removing, modifying and/or recreating various components of index files in response to detecting one or more storage conditions related to the event data indexed by the index files. The optimization of index files generally may attempt to manage a tradeoff between an efficiency with which search requests can be processed using the index files and an amount of storage space occupied by the index files.

Abstract: Various devices, such as storage devices or systems are configured to efficiently manage and determine control table sets. Such a device may include a processor, a memory array including a plurality of memory devices which include a plurality of control table sets stored in a plurality of regions, and a control table set determination logic configured to: receive a command from a host device associated with logical to physical address mapping updates, determine a control table set of the plurality of control table sets associated with the command, determine a region of the plurality of regions associated with the determined control table set, determine a position in the control table set in the determined region associated with the command, generate additional control table sets upon a first determination that the position is not vacant, and store the command in the generated additional control table sets.