Patents by Inventor Ashish Pandey
Ashish Pandey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11954073Abstract: Disclosed are techniques for multi-protocol multi-site file replication, including a method comprising capturing, at a gateway device, IO operations performed on a filesystem, the filesystem having inode bits. The method may further comprise enqueuing the captured IO operations onto a plurality of queues, wherein each of the plurality of queues is associated with one of a plurality of target sites; and independently managing replication of the IO operations to the target sites using the inode bits.Type: GrantFiled: March 16, 2022Date of Patent: April 9, 2024Assignee: International Business Machines CorporationInventors: Venkateswara Rao Puvvada, Saket Kumar, Karrthik Kalaga Gopalakrishnan, Ashish Pandey
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Patent number: 11946052Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: GrantFiled: November 24, 2023Date of Patent: April 2, 2024Assignee: VedaBio, Inc.Inventors: Ariana Mostafa, Jacob Berger, Ashish Pandey, Anurup Ganguli
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Publication number: 20240102014Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: ApplicationFiled: November 24, 2023Publication date: March 28, 2024Inventors: Ariana Mostafa, Jacob Berger, Ashish Pandey, Anurup Ganguli
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Publication number: 20240035028Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods provide signal boost upon detection of target nucleic acids of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 16° C. or less, without amplification of the target nucleic acids yet allowing for massive multiplexing, high accuracy and minimal non-specific signal generation.Type: ApplicationFiled: August 16, 2023Publication date: February 1, 2024Inventors: Anurup Ganguli, Ashish Pandey, Ariana Mostafa, Jacob Berger
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Patent number: 11884921Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods provide signal boost upon detection of target nucleic acids of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 16° C. or less, without amplification of the target nucleic acids yet allowing for massive multiplexing, high accuracy and minimal non-specific signal generation.Type: GrantFiled: December 9, 2022Date of Patent: January 30, 2024Assignee: VedaBio, Inc.Inventors: Anurup Ganguli, Ashish Pandey, Ariana Mostafa, Jacob Berger
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Patent number: 11884922Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: GrantFiled: June 10, 2023Date of Patent: January 30, 2024Assignee: VedaBio, Inc.Inventors: Ariana Mostafa, Jacob Berger, Ashish Pandey, Anurup Ganguli
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Publication number: 20240026425Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula IV, wherein Formula IV in the 5?-to-3? direction comprises: T-D-M-A-Lp-C; wherein T is 17-31 nucleotides in length; D is 0-15 nucleotides in length; M is 1-25 nucleotides in length; A is 0-15 nucleotides in length and comprises a sequence complementary to D; and L is 3-25 nucleotides in length; p is 0 or 1; C is 4-15 nucleotides in length and comprises a sequence complementary to T; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.Type: ApplicationFiled: September 24, 2023Publication date: January 25, 2024Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey, Rashid Bashir
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Publication number: 20240018518Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: ApplicationFiled: June 10, 2023Publication date: January 18, 2024Inventors: Ariana Mostafa, Jacob Berger, Ashish Pandey, Anurup Ganguli
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Patent number: 11859182Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: GrantFiled: May 31, 2023Date of Patent: January 2, 2024Assignee: VedaBio, Inc.Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey
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Publication number: 20230399682Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula III in the 5?-to-3? direction comprises: T-D-M-A-(B-L)J-C; wherein T is 17-135 nucleotides in length; D is 0-10 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then T-D and A-(B-L)J-C are separate nucleic acid strands; A is 0-15 nucleotides in length and comprises at least 50% sequence complementarity to D; B is 4-12 nucleotides in length and comprises at least 50% sequence complementarity to T; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.Type: ApplicationFiled: June 10, 2023Publication date: December 14, 2023Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey, Rashid Bashir
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Patent number: 11820983Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: GrantFiled: December 6, 2022Date of Patent: November 21, 2023Assignee: LabSimply, Inc.Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey
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Patent number: 11821025Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.Type: GrantFiled: May 31, 2023Date of Patent: November 21, 2023Assignees: VedaBio, Inc., The Board of Trustees of The University of IllinoisInventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey, Rashid Bashir
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Publication number: 20230340573Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.Type: ApplicationFiled: May 31, 2023Publication date: October 26, 2023Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey, Rashid Bashir
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Patent number: 11789825Abstract: A computer-implemented method according to one embodiment includes receiving, on a first cluster site, a first I/O request to migrate a plurality of filesets from a second cluster site to the first cluster site. The first cluster site includes a plurality of gateway nodes. The method further includes identifying at least two of the gateway nodes having resources available to perform operations of the migration, and hashing information of a plurality of filesets against the identified gateway nodes. The information includes inode numbers of entities that are mounted during fulfillment of the first I/O request. Operations of the first I/O request are distributed to the identified gateway nodes based on the hashing, and the identified gateway nodes are instructed to fulfill the operations.Type: GrantFiled: November 23, 2020Date of Patent: October 17, 2023Assignee: International Business Machines CorporationInventors: Venkateswara Rao Puvvada, Karrthik Kalaga Gopalakrishnan, Saket Kumar, Ashish Pandey
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Publication number: 20230297548Abstract: Disclosed are techniques for multi-protocol multi-site file replication, including a method comprising capturing, at a gateway device, IO operations performed on a filesystem, the filesystem having inode bits. The method may further comprise enqueuing the captured IO operations onto a plurality of queues, wherein each of the plurality of queues is associated with one of a plurality of target sites; and independently managing replication of the IO operations to the target sites using the inode bits.Type: ApplicationFiled: March 16, 2022Publication date: September 21, 2023Inventors: Venkateswara Rao Puvvada, Saket Kumar, Karrthik Kalaga Gopalakrishnan, Ashish Pandey
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Publication number: 20230287423Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.Type: ApplicationFiled: May 31, 2023Publication date: September 14, 2023Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey
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Publication number: 20230279375Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods provide signal boost upon detection of target nucleic acids of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 16° C. or less, without amplification of the target nucleic acids yet allowing for massive multiplexing, high accuracy and minimal non-specific signal generation.Type: ApplicationFiled: December 8, 2022Publication date: September 7, 2023Inventors: Anurup Ganguli, Ashish Pandey, Ariana Mostafa, Jacob Berger
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Publication number: 20230235381Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.Type: ApplicationFiled: February 6, 2023Publication date: July 27, 2023Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey, Rashid Bashir
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Patent number: 11704289Abstract: Provided are techniques for role reversal of primary and secondary sites with minimal replication delay. During a backup phase, an Input/Output (I/O) operation selected from a group comprising a create operation and a rename operation is received with one or more local attributes of a local file. The I/O operation is processed to generate one or more remote attributes. The one or more local attributes are stored with the one or more remote attributes. During a reversed phase, a write operation for the remote file is processed, and, the write operation is sent to the primary replication system with the one or more local attributes, where the primary replication system uses a local file handle in the one or more local attributes to access the local file for processing the write operation to sync the local file with the remote file.Type: GrantFiled: July 6, 2021Date of Patent: July 18, 2023Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Venkateswara Rao Puvvada, Karrthik Kalaga Gopalakrishnan, Ashish Pandey, Saket Kumar
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Patent number: 11702686Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.Type: GrantFiled: February 6, 2023Date of Patent: July 18, 2023Assignees: LabSimply, Inc., The Board of Trustees of the University of IllinoisInventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey, Rashid Bashir