Abstract: Historical web-based service performance metric values and the historical web-based standards are analyzed to determine maturity classifications for a plurality of regions over a time period. The historical web-based standards applied to each of the regions at different times within the time period are compared, and current web-based standards for one or more regions are adjusted based on the comparison to improve web-based service performance in the one or more regions.

Abstract: Pharmacophores in molecules may be identified by generating a set of conformations for a respective molecule. A respective conformation includes a series of features that are present or absent in the conformation, wherein a respective feature includes at least two molecular elements and at least one distance between the molecular elements. The features for a set of conformations for a given molecule are repeatedly compared to a model of feature importance of remaining molecules, to identify an inferred conformation of a given molecule, until the model of feature importance for the molecules converges.