Patents by Inventor Ashish Sarode

Ashish Sarode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of preparing mRNA-loaded lipid nano particles
    Patent number: 12636252
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
    Type: Grant
    Filed: July 2, 2024
    Date of Patent: May 26, 2026
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Zarna Patel, Yi Zhang, Ashish Sarode, Rebecca L. Goldman, Frank DeRosa, Michael Heartlein
  • Dry powder formulations for messenger RNA
    Patent number: 12594245
    Abstract: The present invention provides stable, dry powder messenger RNA formulations for therapeutic use, and methods of making and using the same.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: April 7, 2026
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Michael Heartlein, Shrirang Karve, Zarna Patel, Ashish Sarode
  • PEG lipidoid compounds
    Patent number: 12514932
    Abstract: The compounds disclosed herein (e.g., compounds having a structure according to Formula (I), (II), (III), (IV), and (V)) are polymers wherein an organic polymeric segment (e.g., a polyethylene glycol (PEG) group) comprises covalent attachments to two or more lipid substructures, and each lipid substructure independently comprises a hydrophobic moiety and a hydrophilic moiety. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: January 6, 2026
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode
  • Dry Powder Formulations for Messenger RNA
    Publication number: 20250345280
    Abstract: The present invention provides stable, dry powder messenger RNA formulations for therapeutic use, and methods of making and using the same.
    Type: Application
    Filed: July 22, 2025
    Publication date: November 13, 2025
    Inventors: Shrirang Karve, Frank DeRosa, Michael Heartlein, Zarna Patel, Ashish Sarode
  • Messenger RNA vaccines and uses thereof
    Patent number: 12370262
    Abstract: The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: July 29, 2025
    Assignee: Translate Bio, Inc.
    Inventors: Shrirang Karve, Zarna Patel, Ashish Sarode, Yi Zhang, Frank DeRosa, Michael Heartlein
  • STABLE COMPOSITIONS OF MRNA-LOADED LIPID NANOPARTICLES AND PROCESSES OF MAKING
    Publication number: 20250049954
    Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
    Type: Application
    Filed: October 9, 2024
    Publication date: February 13, 2025
    Inventors: Shrirang KARVE, Frank DEROSA, Michael HEARTLEIN, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish SARODE
  • PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
    Publication number: 20250025430
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
    Type: Application
    Filed: June 25, 2024
    Publication date: January 23, 2025
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
  • PROCESS OF PREPARING MRNA-LOADED LIPID NANO PARTICLES
    Publication number: 20250025419
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
    Type: Application
    Filed: July 2, 2024
    Publication date: January 23, 2025
    Inventors: Shrirang Karve, Zarna Patel, Yi Zhang, Ashish Sarode, Rebecca L. Goldman, Frank DeRosa, Michael Heartlein
  • Stable compositions of MRNA-loaded lipid nanoparticles and processes of making
    Patent number: 12144871
    Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: November 19, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Frank DeRosa, Michael Heartlein, Natalia Vargas Montoya, Priyal Patel, Ashish Sarode
  • PROCESSES OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
    Publication number: 20240366798
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.
    Type: Application
    Filed: March 12, 2024
    Publication date: November 7, 2024
    Inventors: Shrirang Karve, Ashish Sarode, Frank DeRosa
  • Process of preparing mRNA-loaded lipid nanoparticles
    Patent number: 12064515
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: August 20, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Zarna Patel, Yi Zhang, Ashish Sarode, Rebecca L. Goldman, Frank DeRosa, Michael Heartlein
  • Process of preparing mRNA-loaded lipid nanoparticles
    Patent number: 12053551
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: August 6, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
  • Processes of preparing mRNA-loaded lipid nanoparticles
    Patent number: 11969480
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: April 30, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Ashish Sarode, Frank DeRosa
  • PEG LIPIDOID COMPOUNDS
    Publication number: 20230226219
    Abstract: The compounds disclosed herein (e.g., compounds having a structure according to Formula (I), (II), (III), (IV), and (V)) are polymers wherein an organic polymeric segment (e.g., a polyethylene glycol (PEG) group) comprises covalent attachments to two or more lipid substructures, and each lipid substructure independently comprises a hydrophobic moiety and a hydrophilic moiety. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
    Type: Application
    Filed: May 13, 2021
    Publication date: July 20, 2023
    Inventors: Shrirang KARVE, Frank DEROSA, Ashish SARODE
  • IMPROVED MRNA-LOADED LIPID NANOPARTICLES AND PROCESSES OF MAKING THE SAME
    Publication number: 20230181483
    Abstract: The present invention provides an improved lipid nanoparticle formulation encapsulating mRNA comprising DEPE as a helper lipid.
    Type: Application
    Filed: July 8, 2020
    Publication date: June 15, 2023
    Inventors: Shrirang Karve, Ashish Sarode, Frank DeRosa
  • RECTAL DELIVERY OF MESSENGER RNA
    Publication number: 20230051811
    Abstract: The present invention provides, among other things, effective methods and compositions for delivering messenger RNA (mRNA) via rectal delivery. The present invention is, in part, based on unexpected observation that mRNA may be effectively delivered to the circulation, liver, kidney, colon and/or rectum via rectal delivery despite the barriers such as RNase and mucus layer.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 16, 2023
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode
  • Dry Powder Formulations for Messenger RNA
    Publication number: 20230000781
    Abstract: The present invention provides stable, dry powder messenger RNA formulations for therapeutic use, and methods of making and using the same.
    Type: Application
    Filed: May 16, 2022
    Publication date: January 5, 2023
    Inventors: Frank DeRosa, Michael Heartlein, Shrirang Karve, Zarna Patel, Ashish Sarode
  • PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
    Publication number: 20220395459
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
    Type: Application
    Filed: May 5, 2022
    Publication date: December 15, 2022
    Inventors: Shrirang Karve, Zarna Patel, Yi Zhang, Ashish Sarode, Rebecca L. Goldman, Frank DeRosa, Michael Heartlein
  • MESSENGER RNA VACCINES AND USES THEREOF
    Publication number: 20220347307
    Abstract: The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.
    Type: Application
    Filed: March 28, 2022
    Publication date: November 3, 2022
    Inventors: Shrirang Karve, Zarna Patel, Ashish Sarode, Yi Zhang, Frank DeRosa, Michael Heartlein
  • Stable Liquid Lipid Nanoparticle Formulations
    Publication number: 20220287966
    Abstract: The present invention provides, among other things, a liquid lipid nanoparticle (LNP) formulation encapsulating mRNA encoding a peptide or polypeptide, that is resistant to aggregation and to mRNA degradation following multiple rounds of freezing at ?20° C. and rethawing.
    Type: Application
    Filed: November 24, 2021
    Publication date: September 15, 2022
    Inventors: Shrirang Karve, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel, Frank DeRosa