Abstract: The present invention is directed to a dual inhibitor of phosphoinositide 3-kinase (PI3K) and histone deacetylase (HDAC), including a core containing a quinazoline moiety or a quinazolin-4(3H)-one moiety, a kinase hinge binding moiety, and a histone deacetylase pharmacophore, a pharmaceutically acceptable salt thereof, a prodrug thereof, or solvate thereof. The present invention is also directed to a histone deacetylase inhibitor, including a core containing a quinazolin-4(3H)-one moiety and a histone deacetylase pharmacophore.

Abstract: The present invention comprises compounds and compositions thereof for enhanced drug delivery. Pro-drug and double pro-drug derivatives of corticosteroids non-steroid anti-inflammatory drugs (NSAIDs), and ruboxistaurin for delivery to the eye are provided. The compounds and compositions are useful for treating various ocular diseases, including ocular diseases effecting the posterior segments of the eye. In addition, the present invention is directed to particle in particle carrier formulations for sustained release of therapeutic agents.

Abstract: The present invention comprises compounds and compositions thereof for enhanced drug delivery. Pro-drug and double pro-drug derivatives of corticosteroids non-steroid anti-inflammatory drugs (NSAIDs), and ruboxistaurin for delivery to the eye are provided. The compounds and compositions are useful for treating various ocular diseases, including ocular diseases effecting the posterior segments of the eye. In addition, the present invention is directed to particle in particle carrier formulations for sustained release of therapeutic agents.

Abstract: The present invention comprises compounds and compositions thereof for enhanced drug delivery. Pro-drug and double pro-drug derivatives of corticosteroids non-steroid anti-inflammatory drugs (NSAIDs), and ruboxistaurin for delivery to the eye are provided. The compounds and compositions are useful for treating various ocular diseases, including ocular diseases effecting the posterior segments of the eye. In addition, the present invention is directed to particle in particle carrier formulations for sustained release of therapeutic agents.

Abstract: An image processor in an image capture device compensates for the effects of undesirable camera shakes occurring during video capture The image processor receives a pair of source frames representing images of a scene, generates a pair of subsampled frames from the source frames, and computes a coarse displacement of the captured image due to camera shakes by comparing the two subsampled frames. The image processor may then refine the determined coarse displacement by comparing the two source frames and a bound determined by an extent of subsampling, and compensate for the displacement accordingly. Display aberrations such as blank spaces caused due to shifting are also avoided by displaying only a portion of the captured image and shifting the displayed portion to compensate for camera shake. The image processor also recognizes displacements due to intentional camera movement, and does not correct for such displacements.

Abstract: An image processor in an image capture device compensates for the effects of undesirable camera shakes occurring during video capture The image processor receives a pair of source frames representing images of a scene, generates a pair of subsampled frames from the source frames, and computes a coarse displacement of the captured image due to camera shakes by comparing the two subsampled frames. The image processor may then refine the determined coarse displacement by comparing the two source frames and a bound determined by an extent of subsampling, and compensate for the displacement accordingly. Display aberrations such as blank spaces caused due to shifting are also avoided by displaying only a portion of the captured image and shifting the displayed portion to compensate for camera shake. The image processor also recognizes displacements due to intentional camera movement, and does not correct for such displacements.