Abstract: The present invention provides a method of reducing nucleic acid contamination on a surface, which comprises the steps of contacting a surface to be decontaminated with a solution of hydrogen peroxide and water; and subsequently wiping the solution from the surface. Preferably, the solution consists essentially of hydrogen peroxide and water. The solution may also be sprayed on a surface, or applied first to a paper towel or the like, and then applied to a surface. The concentration of the hydrogen peroxide solution is dilute. Concentrations of about 0.5% to about 30% are preferred. A concentration of about 3% is most highly preferred.