Abstract: A method and an apparatus for generating a brain break alert is provided. The method includes receiving electroencephalographic (EEG) data of a patient engaged in a cognitive activity at a system server from a user device. The EEG data is captured by electrode of an EEG headset, where the electrode is in physical contact with the patient, and the EEG headset is communicably coupled to the user device. Brain energy used (BEU) by the patient is determined based on the EEG data, brain energy available (BEA) to the patient is determined as a function of the BEU and a predefined initial brain energy (BEI) of the patient, where the BEA is proportional to a difference between the BEI and the BEU, and the BEA satisfying a brain break alert threshold is determined, upon which an instruction to generate a brain break alert (BBA) is sent to the user device.

Abstract: The present invention relates to methods, uses, a first MCM5 binding agent and/or a second MCM5 binding agents and kits for detecting the presence or absence of a cancer in a subject and/or diagnosing a subject with a cancer and/or monitoring a subject for recurrence of a cancer.