Abstract: The vacuum biopsy apparatus includes a syringe having a side wall defining a chamber. It further includes a vacuum tube receivable within the syringe chamber. The vacuum tube has a septum at one end. The septum is shaped and dimensioned received within the syringe chamber with a fluid type fit. The vacuum tube and the septum are capable of movement within the syringe chamber to enable the vacuum tube to serve as the syringe plunger. Venting means are provided on the syringe side wall to prevent expelling air from the syringe when the vacuum tube is moved within the syringe chamber. The syringe includes mating means to allow the syringe to be connected to a biopsy needle. This allows communication between the biopsy needle and the vacuum tube when the vacuum tube is within the syringe chamber and the biopsy needle is connected to the syringe.