Abstract: Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject.

Abstract: Provided are systems and methods to temporarily alter visual acuity of a subject. An example system includes a first light source configured to produce infrared light in an infrared wavelength spectrum for transient propagation into an eye of the subject and a second light source configured to produce visible light in a visible wavelength spectrum for transient propagation into the eye of the subject. The system further includes a transmission unit configured to propagate the infrared light and the visible light into the eye, wherein the light propagated into the eye temporarily alters visual acuity of the subject.

Abstract: Provided are systems and methods to temporarily alter visual acuity of a subject. An example system includes a first light source configured to produce infrared light in an infrared wavelength spectrum for transient propagation into an eye of the subject and a second light source configured to produce visible light in a visible wavelength spectrum for transient propagation into the eye of the subject. The system further includes a transmission unit configured to propagate the infrared light and the visible light into the eye, wherein the light propagated into the eye temporarily alters visual acuity of the subject.

Abstract: Provided are systems operable to effect a temporary change in a modulation transfer function (MTF) of a target imaging system. The systems include a light source operable to produce light for transient propagation onto at least a portion of the target imaging system, a power source in operative communication with the light source and configured to effect the production of light from the light source, and a transmission unit in operative communication with the light source and configured to propagate the produced light onto at least a portion of the target imaging system. The propagated light is configured for absorbance by the portion of the target imaging system; the absorbance causes an increase in temperature and a change in a refractive index profile of at least the portion of the imaging system. The change in refractive index profile produces a temporary change in the MTF of the imaging system.

Abstract: Methods, systems, and apparatus for delivering drugs for treatment of eye disease are described. For example, the methods, systems, and apparatus can be optionally used to treat wet age-related macular degeneration. In some examples, an eye disease is treated by implanting a device comprising a sealed container into the diseased eye. A dosage of drug for treating the diseased eye is disposed within the sealed container. The dosage of the drug is selectively released from the sealed container of the implanted device into eye tissue. The released dosage treats the eye disease.

Abstract: Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject.

Abstract: Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion. Blood flow velocity is slowed within the region using the hyperosmotic agent, and the lesion is exposed to laser radiation.

Abstract: Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion. Blood flow velocity is slowed within the region using the hyperosmotic agent, and the lesion is exposed to laser radiation.

Abstract: A composition and method for a light activated composition for improved wound closure, is disclosed. The composition includes a biodegradable polymer that is impregnated with a solder that is biologically compatible and a chromophoric dye. The chromophoric dye enhances the amount of light energy that the composition absorbs.

Abstract: A new process to increase light transmission in biological tissue has been developed. The technique involves temporarily replacing tissue water with a fluid that has a refractive index closer to that of inter/intra cellular components. Subsequently, the amount of index mis-match between these components and the fluid environment is temporarily decreased. This lowers the amount of random reflection and refraction which also reduces light scattering. In addition, the infrared absorption is reduced when the fluid has a lower absorption coefficient than water. Furthermore, this process is reversible; thus creating a transient window to enhance light transmission for therapeutic and/or diagnostic applications.