Abstract: A clamping device for a shaft of a catheter can include a first member rotatably coupled to a second member. The first member can have an annular element defining a central lumen, the outer surface of the annular element having a non-circular cross-sectional profile, and the second member can define a bore into which the annular element extends, the bore having a non-circular cross-sectional profile. The device can move between a release state wherein the central lumen has a first diameter, and a clamped state wherein the central lumen has a second diameter less than the first diameter. When the clamping device is in the clamped state, the clamping device can engage an outer surface of a catheter shaft and when the clamping device is in the release state, the clamping device can be moved along a length of the catheter shaft.