Patents by Inventor Ashley Leonard
Ashley Leonard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9572834Abstract: In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups.Type: GrantFiled: April 26, 2012Date of Patent: February 21, 2017Assignees: WILLIAM MARSH RICE UNIVERSITY, BAYLOR COLLEGE OF MEDICINEInventors: James M. Tour, Jacob Berlin, Daniela Marcano, Ashley Leonard, Thomas A. Kent, Robia G. Pautler, Brittany Bitner, Taeko Inoue
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Patent number: 8840803Abstract: A nanocomposite fluid includes a fluid medium; and a nanoparticle composition comprising nanoparticles which are electrically insulating and thermally conductive. A method of making the nanocomposite fluid includes forming boron nitride nanoparticles; dispersing the boron nitride nanoparticles in a solvent; combining the boron nitride nanoparticles and a fluid medium; and removing the solvent.Type: GrantFiled: February 2, 2012Date of Patent: September 23, 2014Assignee: Baker Hughes IncorporatedInventors: Oleg A. Mazyar, Ashley Leonard, Joshua C. Falkner
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Patent number: 8784866Abstract: Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.Type: GrantFiled: October 3, 2008Date of Patent: July 22, 2014Assignees: William Marsh Rice University, Board of Regents, The University of Texas SystemInventors: James M. Tour, Rebecca Lucente-Schultz, Ashley Leonard, Dmitry V. Kosynkin, Brandi Katherine Price, Jared L. Hudson, Jodie L. Conyers, Jr., Valerie C. Moore, S. Ward Casscells, Jeffrey N. Myers, Zvonimir L. Milas, Kathy A. Mason, Luka Milas
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Publication number: 20140120081Abstract: In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups.Type: ApplicationFiled: April 26, 2012Publication date: May 1, 2014Applicants: Baylor College of Medicine, William Marsh Rice UniversityInventors: James M. Tour, Jacob Berlin, Daniela Marcano, Ashley Leonard, Thomas A. Kent, Robia G. Pautler, Brittany Bitner, Taeko Inoue
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Publication number: 20130200299Abstract: A nanocomposite fluid includes a fluid medium; and a nanoparticle composition comprising nanoparticles which are electrically insulating and thermally conductive. A method of making the nanocomposite fluid includes forming boron nitride nanoparticles; dispersing the boron nitride nanoparticles in a solvent; combining the boron nitride nanoparticles and a fluid medium; and removing the solvent.Type: ApplicationFiled: February 2, 2012Publication date: August 8, 2013Applicant: Baker Hughes IncorporatedInventors: Oleg A. Mazyar, Ashley Leonard, Joshua C. Falkner
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Patent number: 8352568Abstract: A system, apparatus, method and computer program product are provided for configuring disparate workstations. In particular, an administrative utility is provided that may allow users to upload to a configuration server individual configuration files for applications executing on workstations associated with physiological devices. Once uploaded, a user may group the configuration files into configuration groups based, for example, on similarities in configurations utilized. Once a configuration group has been created, the user may assign one or more workstations to each configuration group. Upon startup of a workstation, an application executing on the workstation may automatically transmit a request to the configuration server to load the configurations for that workstation. In response, the configuration server may determine to which configuration group the workstation has been assigned, and then download the configuration files of that configuration group to the workstation.Type: GrantFiled: May 12, 2008Date of Patent: January 8, 2013Assignee: McKesson Financial HoldingsInventors: Kelly Walker, Charles Ashley Leonard
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Publication number: 20120142111Abstract: Compositions containing a transporter component and a signaling component and a method for using said compositions for analyzing porous media and flowing liquid streams, specifically for measuring pressure, temperature, relative abundance of water, pH, redox potential and electrolyte concentration. Analytes may include petroleum or other hydrophobic media, sulfur-containing compounds. The transporter component includes an amphiphilic nanomatenal and a plurality of solubilizing groups covalently bonded to the transporter component. The signaling component includes a plurality of reporter molecules associated with the transporter component. Said reporter molecules may be releasable from the transporter component upon exposure to at least one analyte. The reporter molecules may be non-covalently associated with the transporter component, or the reporter molecules are covalently bonded to the transporter component.Type: ApplicationFiled: June 11, 2010Publication date: June 7, 2012Inventors: James M. Tour, Dmitry Kosynkin, Michael Wong, Mason Tomson, Jacob Berlin, Ashley Leonard, Jay Lomeda, Wei Lu, Jie yu, Lunliang Zhang, Amy Kan
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Publication number: 20120032543Abstract: An improved oil composition is disclosed. The oil composition includes a base oil comprising a hydrocarbon, the base oil having a base thermal conductivity. The oil composition also includes a first additive comprising a plurality of derivatized first additive nanoparticles dispersed within the base oil to form a modified oil having a modified thermal conductivity, wherein the modified thermal conductivity is greater than the base thermal conductivity. Alternately, an improved oil composition includes a base oil comprising a hydrocarbon and a first additive comprising a plurality of derivatized first additive nanoparticles dispersed within the base oil to form a modified oil comprising a stabilized suspension of the derivatized first additive nanoparticles in the base oil.Type: ApplicationFiled: February 4, 2011Publication date: February 9, 2012Applicant: BAKER HUGHES INCORPORATEDInventors: Soma Chakraborty, Ashley Leonard, Gaurav Agrawal, Ketankumar K. Sheth
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Publication number: 20100197783Abstract: A method of reducing side effects of damage in a human subject exposed to radiation includes administering to the human subject carbon nanotubes in a pharmaceutically acceptable carrier after or prior to exposure to radiation. A composition for reducing radical damage includes a carbon nanotube which is functionalized (1) for substantial water solubility and (2) with a radical trapping agent appended to the carbon nanotube forming a radical scavenger-carbon nanotube conjugate.Type: ApplicationFiled: March 26, 2008Publication date: August 5, 2010Inventors: James M. Tour, Meng Lu, Rebecca Lucente-Schultz, Ashley Leonard, Condell Dewayne Doyle, Dmitry V. Kosynkin, Brandi Katherine Price
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Publication number: 20090282133Abstract: A system, apparatus, method and computer program product are provided for configuring disparate workstations. In particular, an administrative utility is provided that may allow users to upload to a configuration server individual configuration files for applications executing on workstations associated with physiological devices. Once uploaded, a user may group the configuration files into configuration groups based, for example, on similarities in configurations utilized. Once a configuration group has been created, the user may assign one or more workstations to each configuration group. Upon startup of a workstation, an application executing on the workstation may automatically transmit a request to the configuration server to load the configurations for that workstation. In response, the configuration server may determine to which configuration group the workstation has been assigned, and then download the configuration files of that configuration group to the workstation.Type: ApplicationFiled: May 12, 2008Publication date: November 12, 2009Applicant: MCKESSON FINANCIAL HOLDINGS LIMITEDInventors: Kelly Walker, Charles Ashley Leonard
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Publication number: 20090170768Abstract: Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.Type: ApplicationFiled: October 3, 2008Publication date: July 2, 2009Applicant: William Marsh Rice UniversityInventors: James M. Tour, Valerie C. Moore, S. Ward Casscella, Jeffrey N. Myers, Zvonimir L. Milas, Kathy A. Mason, Luka Milas, Brandl Katherine Price, Jared L. Hudson, Jodie L. Conyers, JR., Rebecca L. Lucente-Schultz, Ashley Leonard, Dmitry V. Kosynkin