Patents by Inventor Ashley Luck

Ashley Luck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11993792
    Abstract: The present disclosure relates, according to some embodiments, to systems, apparatus, compositions, methods, and workflows that include DNase I variants with desirable properties including, for example, salt tolerance. A DNase I variant, in some embodiments, may have an amino acid sequence that is at least 85% identical, at least 90% identical, at least 95% identical, and/or at least 98% identical to SEQ ID NO:1 and may be identical to SEQ ID NO:1 at one or more positions selected from the group of positions corresponding to L29, A35, D87, Q88, S94, P103, T108, P121, P132, A135, D145, E161, G172, P190, H208, and A224 of SEQ ID NO:1.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: May 28, 2024
    Assignee: New England Biolabs, Inc.
    Inventors: Heidi Crosby, Jennifer Ong, Ashley Luck, Eric J. Cantor, Vladimir Potapov
  • Publication number: 20220380741
    Abstract: The present disclosure relates, according to some embodiments, to systems, apparatus, compositions, methods, and workflows that include DNase I variants with desirable properties including, for example, salt tolerance. A DNase I variant, in some embodiments, may have an amino acid sequence that is at least 85% identical, at least 90% identical, at least 95% identical, and/or at least 98% identical to SEQ ID NO:1 and may be identical to SEQ ID NO:1 at one or more positions selected from the group of positions corresponding to L29, A35, D87, Q88, S94, P103, T108, P121, P132, A135, D145, E161, G172, P190, H208, and A224 of SEQ ID NO:1.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 1, 2022
    Applicant: New England Biolabs, Inc.
    Inventors: Heidi Crosby, Jennifer Ong, Ashley Luck, Eric J. Cantor, Vladimir Potapov
  • Publication number: 20180362960
    Abstract: Among other things, a method for performing multiple enzyme reactions in a single tube is provided. In some embodiments, the method may comprise producing a reaction mix comprising a thermolabile UDG, an AP lyase and DNA fragments that comprise one or more uracil residues, incubating the reaction mix at a relatively low temperature to cleave fragments at the one or more uracil residues, raising the temperature of the reaction mix to a relatively high temperature to inactivate the thermolabile UDG; and deaminating the fragments, thereby converting any cytosine in the fragments of DNA to uracil.
    Type: Application
    Filed: June 15, 2017
    Publication date: December 20, 2018
    Applicant: New England Biolabs, Inc.
    Inventors: Romualdas Vaisvila, Lauren Higgins, Ashley Luck
  • Patent number: 10155939
    Abstract: Among other things, a method for performing multiple enzyme reactions in a single tube is provided. In some embodiments, the method may comprise producing a reaction mix comprising a thermolabile UDG, an AP lyase and DNA fragments that comprise one or more uracil residues, incubating the reaction mix at a relatively low temperature to cleave fragments at the one or more uracil residues, raising the temperature of the reaction mix to a relatively high temperature to inactivate the thermolabile UDG; and deaminating the fragments, thereby converting any cytosine in the fragments of DNA to uracil.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: December 18, 2018
    Assignee: New England Biolabs, Inc.
    Inventors: Romualdas Vaisvila, Lauren Higgins, Ashley Luck