Abstract: Mechanical circulatory support systems and methods are disclosed herein. In some examples, the present technology comprises a system for providing cardiac support to a patient where the system comprises a first elongated shaft configured to receive a delivery catheter therethrough, a second elongated shaft, and a pressure source coupled to the first and second elongated shafts. The first elongated shaft may have a distal end portion configured to be intravascularly positioned at a first cardiovascular location, and the second elongated shaft may have a distal end portion configured to be intravascularly positioned at a second cardiovascular location downstream of the first location. Pressure generated by the pressure source pulls blood from the first location proximally through the first shaft to the pressure source, then pushes the blood distally through the second shaft and into circulatory flow at the second cardiovascular location, thereby providing mechanical circulatory support to the patient.

Abstract: Devices, systems, and methods for treating chronic rhinosinutisits (CRS) are described herein. The devices can have a guide member defining at least one lumen therethrough. A drug delivery component is advanced through the lumen to deliver a substance to the sino-nasal cavity of a patient. Once the drug delivery component is positioned at the desired area in the sino-nasal cavity, a user actuates the system to deliver the substance to the target area. Actuation of the system delivers the substance to the middle meatus, osteo-meatal complex, or other areas within the sino-nasal cavity of the patient.

Abstract: Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed.

Abstract: The present invention includes an introducer sheath. The sheath may comprise a first proximal elongated section having a first outer diameter and a first inner diameter, and a main body elongated section having a second inner diameter and a second outer diameter, wherein the second outer diameter is larger than the first outer diameter. The sheath may further include a distal section having an outer wall that tapers from the second outer diameter of the main body elongated section to a smaller distal outer diameter.

Abstract: Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed.

Abstract: Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed.

Abstract: A device for introducing an embolic coil into a catheter comprises an elongated body defining a longitudinal passage extending therethrough from a first opening at a proximal end thereof to a second opening at a distal end thereof, the elongated body being including a mating portion for conforming to a size and shape of an opening in a hub of a catheter to mate therewith and an embolic coil introducer sheath including a coil receiving lumen extending therethrough, a distal tip of the introducer sheath being dimensioned to be received within a proximal end of the longitudinal passage. Similarly, a method of implanting an embolic coil, comprises inserting a stabilizer into a catheter hub so that a flexible mating portion substantially conforms to a shape of an inner surface of the hub wherein the stabilizer includes a passage extending therethrough from a proximal opening to a distal opening thereof.

Abstract: Coil assemblies and related components and methods are disclosed. The coil assemblies can include two or more embolic coils having one or more different coil parameters.

Abstract: A device for providing fluid to an organ within a living body comprises an elongate member including a distal portion configured for insertion to a target location within a living body. The elongate member includes a withdrawal lumen extending from an outlet in a proximal end thereof to an inlet at a distal end of the elongate member, the inlet opening into a target organ when the distal portion of the elongate member is in the target location. The elongate member further includes an infusion lumen extending from an inlet in the proximal end thereof to an outlet which, when the distal portion of the elongate member is in the target location, opens into the target organ.

Abstract: An embodiment of the invention includes inserting into a gastrointestinal lumen, a catheter having a first balloon and a second balloon spaced from the first balloon. The first balloon and the second balloon are inflated to sealingly engage the lumen. A liquid is introduced into a volume bounded by the first balloon, the second balloon and the lumen so that the liquid contacts at least a portion of the lumen.

Abstract: Medical devices with radiopaque markers, and related systems and methods are disclosed.

Abstract: The present invention includes an introducer sheath. The sheath may comprise a first proximal elongated section having a first outer diameter and a first inner diameter, and a main body elongated section having a second inner diameter and a second outer diameter, wherein the second outer diameter is larger than the first outer diameter. The sheath may further include a distal section having an outer wall that tapers from the second outer diameter of the main body elongated section to a smaller distal outer diameter.

Abstract: An apparatus comprises a snare and an actuator. The snare is formed of a material having an opacity complementary to a predetermined imaging system that is positionable external to a patient. The actuator is configured to steer the snare in response to an image of at least a portion of a colon of the patient. The image is generated by the predetermined imaging system.

Abstract: A device for introducing an embolic coil into a catheter comprises an elongated body defining a longitudinal passage extending therethrough from a first opening at a proximal end thereof to a second opening at a distal end thereof, the elongated body being including a mating portion for conforming to a size and shape of an opening in a hub of a catheter to mate therewith and an embolic coil introducer sheath including a coil receiving lumen extending therethrough, a distal tip of the introducer sheath being dimensioned to be received within a proximal end of the longitudinal passage. Similarly, a method of implanting an embolic coil, comprises inserting a stabilizer into a catheter hub so that a flexible mating portion substantially conforms to a shape of an inner surface of the hub wherein the stabilizer includes a passage extending therethrough from a proximal opening to a distal opening thereof.

Abstract: A method includes identifying an area of interest within a gastrointestinal lumen based on a virtual imaging modality. Energy is applied using an external energy source directed at the area of interest sufficient to disrupt at least a portion of an undesired tissue. In another embodiment, the method includes introducing a contrasting agent into a gastrointestinal lumen. The gastrointestinal lumen is imaged with an imaging device. An area of interest within the gastrointestinal lumen is identified, where the area of interest is indicated by the contrasting agent. Energy is applied using an external energy source directed at the area of interest to disrupt at least a portion of a tissue located at the area of interest. The disrupted tissue is removed from the gastrointestinal lumen.

Abstract: An embodiment of the invention includes inserting into a gastrointestinal lumen, a catheter having a first balloon and a second balloon spaced from the first balloon. The first balloon and the second balloon are inflated to sealingly engage the lumen. A liquid is introduced into a volume bounded by the first balloon, the second balloon and the lumen so that the liquid contacts at least a portion of the lumen.

Abstract: Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed.

Abstract: Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed.

Abstract: Coil assemblies and related components and methods are disclosed. The coil assemblies can include two or more embolic coils having one or more different coil parameters.

Abstract: Embolic coil introducer sheath locking mechanisms, as well as related components, systems and methods are disclosed.