Patents by Inventor Ashley Steed

Ashley Steed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DETERMINING COVID-19 MORTALITY RISK
    Publication number: 20230257820
    Abstract: Among the various aspects of the present disclosure is the provision of detecting COVID-19 severity. One aspect provides a method of predicting survival in subjects having COVID-19 (e.g., critical COVID-19) comprising single-cell RNA sequencing and Cellular Indexing of Transcriptomes and Epitomes by sequence mapping to elucidate cell type specific transcriptional signatures. Another aspect provides for a method of predicting COVID-19 infection survival comprising detecting activation of antibody processing, early activation response, and/or cell cycle regulation pathways most prominent within B-, T-, and/or NK-cell subsets. Yet another aspect provides for a method of predicting mortality in a subject having COVID-19, comprising detecting interferon signaling and antigen presentation pathways within cDC2 cells, CD14 monocytes, and/or CD16 monocytes.
    Type: Application
    Filed: February 14, 2023
    Publication date: August 17, 2023
    Applicant: Washington University
    Inventors: Ashley Steed, Junedh Amrute
  • Compositions comprising desaminotyrosine and uses thereof to enhance type I interferon stimulation
    Patent number: 11058653
    Abstract: The disclosure provides compositions comprising desaminotyrosine and methods of use thereof in enhancing type I interferon stimulation, epithelial proliferation, and treatment of inflammatory bowel disease.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: July 13, 2021
    Assignee: Washington University
    Inventors: Thaddeus Stappenbeck, Ashley Steed, Gerard Kaiko, George Christophi
  • COMPOSITIONS COMPRISING DESAMINOTYROSINE AND USES THEREOF TO ENHANCE TYPE I INTERFERON STIMULATION
    Publication number: 20190274983
    Abstract: The disclosure provides compositions comprising desaminotyrosine and methods of use thereof in enhancing type I interferon stimulation, epithelial proliferation, and treatment of inflammatory bowel disease.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 12, 2019
    Applicant: Washington University
    Inventors: Thaddeus Stappenbeck, Ashley Steed, Gerard Kaiko, George Christophi