Patents by Inventor Ashling McCormack

Ashling McCormack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of L-amino acids
    Patent number: 8445241
    Abstract: This application discloses methods for the preparation of L-amino acids, which comprises fermentation of a desired L-amino acid-producing bacteria in which at least the tal gene is amplified. In some embodiments, genes of the biosynthesis pathway of the desired L-amino acid are additionally amplified.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: May 21, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Ashling McCormack, Cliona Stapelton, Kevin Burke, Bettina Mockel, Rita Dunican
  • Nucleotide Sequences Which Code for the tal Gene
    Publication number: 20110117611
    Abstract: The invention relates to an isolated polynucleotide from coryneform bacteria, comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequences of SEQ ID NO. 2 or SEQ ID NO. 4, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequences of SEQ ID NO. 2 or SEQ ID NO.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 19, 2011
    Applicant: Degussa-Huls AG
    Inventors: L K. Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bettina Mockel
  • Process for the preparation of L-amino acids by overexpressing the tal gene encoding transaldolase
    Patent number: 7901913
    Abstract: The invention is directed to DNA sequences from coryneform bacteria, particularly Corynebacterium glutamicum, which encode a protein having transaldolase enzymatic activity. The invention also encompasses processes for the fermentative production of L-amino acids using bacteria in which a gene encoding transaldolase is amplified.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: March 8, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Laurence Kieran Dunican, Rita Dunican, legal representative, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bettina Mockel
  • Process for the fermentative production of amino acids using bacteria in which OpcA gene expression is amplified
    Patent number: 7504242
    Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: March 17, 2009
    Assignee: Evonik Degussa GmbH
    Inventors: Rita Dunican, legal representative, Ashling McCormack, Cliona Stapelton, Kevin Burke, L. K. Dunican
  • Process for the preparation of L-amino acids with amplification of the zwf gene
    Publication number: 20060014259
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an amplified gene encoding the Zwischenferment protein.
    Type: Application
    Filed: March 6, 2002
    Publication date: January 19, 2006
    Inventors: Kevin Burke, Hermann Sahm, Lothar Eggeling, Bernd Moritz, L. Dunican, Ashling McCormack, Cliona Stapelton, Bettina Mockel, Georg Thierbach, Rita Dunican
  • Nucleotide sequences which code for the opcA gene
    Publication number: 20050112730
    Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
    Type: Application
    Filed: November 1, 2004
    Publication date: May 26, 2005
    Applicant: Degussa AG
    Inventors: L. Dunican, Rita Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bernd Moritz, Lothar Eggeling, Hermann Sahm, Bettina Mockel, Anke Weissenborn
  • Process for the preparation of L-amino acids with amplification of the zwf gene
    Publication number: 20050112733
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an amplified gene encoding the Zwischenferment protein.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 26, 2005
    Inventors: Kevin Burke, Hermann Sahm, Lothar Eggeling, Bernd Moritz, L. Dunican, Ashling McCormack, Cliona Stapleton, Bettina Mockel, Georg Thierbach, Rita Dunican
  • Nucletoide sequences which code for the opcA gene
    Patent number: 6825029
    Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: November 30, 2004
    Assignee: Degussa AG
    Inventors: Laurence K. Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bernd Moritz, Lothar Eggeling, Hermann Sahm, Bettina Möckel, Anke Weissenborn
  • Nucleotide sequences which code for the tal gene
    Publication number: 20040214219
    Abstract: The invention relates to an isolated polynucleotide from coryneform bacteria, comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: May 18, 2004
    Publication date: October 28, 2004
    Applicant: Degussa-Huls AG
    Inventors: L. K. Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bettina Mockel
  • Nucleotide sequences which code for the tal gene
    Patent number: 6797509
    Abstract: The invention is directed to DNA sequences from coryneform bacteria which encode a protein having transaldolase enzymatic activity. The invention also encompasses methods for the fermentative production of L-amino acids using bacteria in which the gene encoding transaldolase is amplified.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: September 28, 2004
    Assignee: Degussa-Huls AG
    Inventors: Laurence Kieran Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bettina Mockel
  • Process for the preparation of L-amino acids using a gene encoding 6-phosphogluconate dehydrogenase
    Publication number: 20040063181
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid produced by the fermenting in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an overexpressed gene encoding 6-phosphogluconate dehydrogenase and a decreased or switched off gene encoding pyruvate oxidase. The L-amino acid may be L-lysine, L-threonine, L-isoleucine or L-tryptophan.
    Type: Application
    Filed: October 17, 2003
    Publication date: April 1, 2004
    Applicants: Degussa-Huls Aktiengasellschaft, National University of Ireland
    Inventors: L. K. Duncan, Ashling McCormack, Cliona Stapleton, Kevin Burke, Bettina Mockel
  • Process for the preparation of L-amino acids with amplification of the zwf gene
    Publication number: 20030199045
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an amplified gene encoding the Zwischenferment protein.
    Type: Application
    Filed: March 6, 2002
    Publication date: October 23, 2003
    Inventors: Kevin Burke, Hermann Sahm, Lothar Eggeling, Bernd Moritz, L. K. Dunican, Ashling McCormack, Cliona Stapelton, Bettina Mockel, Georg Thierbach, Rita Dunican
  • Nucleotide sequences which code for the opcA gene
    Publication number: 20030138917
    Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
    Type: Application
    Filed: May 3, 2002
    Publication date: July 24, 2003
    Inventors: L. K. Dunican, Rita Dunican, Ashling McCormack, Cliona Stapleton, Kevin Burke, Bernd S. Moritz, Lothar Eggeling, Hermann Sahm, Bettina Mockel, Anke Weissenborn
  • Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
    Patent number: 6586214
    Abstract: The present invention is directed to isolated polynucleotides coding for phosphoglucose isomerase (pgi) from coryneform bacteria. In addition, the invention includes methods for increasing the metabolic flux through pentose phosphate cycle of bacteria by reducing or eliminating the activity of pgi. These methods may be used to increase the fermentative production of nucleotides, vitamins and amino acids.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: July 1, 2003
    Assignee: Degussa AG
    Inventors: L. K. Dunican, Ashling McCormack, Cliona Stapleton, Kevin Burke, Michael O'Donohue, Achim Marx, Bettina Mockel
  • Process for the preparation of L-amino acids using a gene encoding 6-phosphogluconate dehydrogenase
    Publication number: 20030119154
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid produced by the fermenting in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an overexpressed gene encoding 6-phosphogluconate dehydrogenase and a decreased or switched off gene encoding pyruvate oxidase. The L-amino acid may be L-lysine, L-threonine, L-isoleucine or L-tryptophan.
    Type: Application
    Filed: February 20, 2002
    Publication date: June 26, 2003
    Inventors: L. K. Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bettina Mockel
  • Process for the fermentative preparation of L-amino acids with amplification of the tkt gene
    Publication number: 20030109014
    Abstract: The invention relates to a process for the preparation of L-amino acids by the fermentation of coryneform bacteria that over-express a gene encoding transketolase.
    Type: Application
    Filed: May 14, 2002
    Publication date: June 12, 2003
    Inventors: Kevin Burke, L. K. Dunican, Rita Duncian, Ashling McCormack, Cliona Stapleton, Bettina Mockel, Georg Thierbach