Patents by Inventor Ashlynn LEE
Ashlynn LEE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11890342Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: GrantFiled: December 22, 2020Date of Patent: February 6, 2024Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Nathaniel Park, Rudy J. Wojtecki, Yang Chuan, Ashlynn Lee, Zhen Chang Liang, Shaoqiong Liu, Yi Yan Yang
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Patent number: 11559578Abstract: A method for formation of a vaccine comprising combining a cationic polymer adjuvant with an antigen to form first immunoparticles through charge interactions and producing a treatment formulation for the vaccine comprising the first immunoparticles.Type: GrantFiled: June 30, 2020Date of Patent: January 24, 2023Assignee: International Business Machines CorporationInventors: James L. Hedrick, Yi Yan Yang, Ashlynn Lee, Chuan Yang
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Publication number: 20220387596Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.Type: ApplicationFiled: August 1, 2022Publication date: December 8, 2022Inventors: Mareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
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Patent number: 11485823Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.Type: GrantFiled: May 23, 2018Date of Patent: November 1, 2022Assignee: Agency for Science, Technology and ResearchInventors: Yi-Yan Yang, Chuan Yang, Wei Cheng, Ashlynn Lee
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Patent number: 11478550Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.Type: GrantFiled: November 21, 2018Date of Patent: October 25, 2022Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGYInventors: Mareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
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Publication number: 20210401977Abstract: A method for formation of a vaccine comprising combining a cationic polymer adjuvant with an antigen to form first immunoparticles through charge interactions and producing a treatment formulation for the vaccine comprising the first immunoparticles.Type: ApplicationFiled: June 30, 2020Publication date: December 30, 2021Inventors: James L. Hedrick, Yi Yan Yang, Ashlynn Lee, Chuan Yang
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Patent number: 11045552Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: GrantFiled: April 4, 2017Date of Patent: June 29, 2021Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Nathaniel H. Park, Rudy J. Wojtecki, Yang Chuan, Ashlynn Lee, Zhen Chang Liang, Shaoqiong Liu, Yi Yan Yang
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Publication number: 20210145970Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: ApplicationFiled: December 22, 2020Publication date: May 20, 2021Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Nathaniel PARK, Rudy J. WOJTECKI, Yang CHUAN, Ashlynn LEE, Zhen Chang LIANG, Shaoqiong LIU, Yi Yan YANG
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Publication number: 20200165390Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.Type: ApplicationFiled: May 23, 2018Publication date: May 28, 2020Applicant: Agency for Science, Technology and ResearchInventors: Yi-Yan Yang, Chuan Yang, Wei Cheng, Ashlynn Lee
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Publication number: 20200155686Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.Type: ApplicationFiled: November 21, 2018Publication date: May 21, 2020Inventors: Mareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
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Publication number: 20180280515Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: ApplicationFiled: April 4, 2017Publication date: October 4, 2018Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Nathaniel H. PARK, Rudy J. WOJTECKI, Yang CHUAN, Ashlynn LEE, Zhen Chang LIANG, Shaoqiong LIU, Yi Yan YANG