Patents by Inventor Ashok Aiyappa

Ashok Aiyappa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for using canine immunoglobulin variable domains and caninized antibodies
    Patent number: 7261890
    Abstract: The present invention provides canine heavy chain and light chain (both ? and ?) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presently disclosed canine variable domain framework sequences and CDRs specific for an antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninization permits the development of useful therapeutics, which includes but is not limited to allergy, osteosarcomma's and lymphomma's.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: August 28, 2007
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Eugene Regis Krah, III, Hongliang Guo, Ashok Aiyappa, Robert Lawton
  • Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
    Publication number: 20040181039
    Abstract: The present invention provides canine heavy chain and light chain (both &lgr; and &kgr;) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presently disclosed canine variable domain framework sequences and CDRs specific for an antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This dislosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninization permits the development of useful therapeutics, which includes but is not limited to allergy, osteosarcomma's and lymphomma's.
    Type: Application
    Filed: December 20, 2002
    Publication date: September 16, 2004
    Inventors: Eugene Regis Krah, Honliang Guo, Ashok Aiyappa, Robert Lawton