Abstract: Described herein is the finding that the PI3K/Akt and TGF-? pathways act cooperatively to promote squamous cell carcinoma (SCC), such as head and neck squamous cell carcinoma (HNSCC). In particular, it was found that conditional deletion of transforming growth factor-? receptor type I (TGFBR1) and phosphatase and tensin homolog (PTEN) in head and neck epithelia of mice led to spontaneous development of SCC in the mice with complete penetrance. Accordingly, provided herein are methods of treating a subject diagnosed with SCC by administering to the subject a therapeutically effective amount of an inhibitor of the PI3K/Akt pathway and a therapeutically effective amount of a modulator of the TGF-? pathway. Also provided is a method of diagnosing a subject as having SCC, or being susceptible to developing SCC, by detecting the presence or absence of at least one tumor-associated mutation in the TGFBR1 gene and at least one tumor-associated mutation in the PTEN gene.

Abstract: An uninterruptible power supply system includes power converter circuitry configured to convert AC input power to a first DC power and a second DC power to the first DC power, a battery pack configured to provide the second DC power, a power relay mechanism coupled to the power converter circuitry and to the battery pack that selectively moves between an open position and a closed position, the power relay mechanism coupling the battery pack to the power converter circuitry when in the closed position and isolating the battery pack from the power converter circuitry when in the open position, and control circuitry configured to provide a control signal, where the power relay mechanism includes a motor actuator coupled to the control circuitry, the motor actuator being responsive to the control signal to change the power relay mechanism from the open position to the closed position.

Abstract: An uninterruptible power supply system includes power converter circuitry configured to convert AC input power to a first DC power and a second DC power to the first DC power, a battery pack configured to provide the second DC power, a power relay mechanism coupled to the power converter circuitry and to the battery pack that selectively moves between an open position and a closed position, the power relay mechanism coupling the battery pack to the power converter circuitry when in the closed position and isolating the battery pack from the power converter circuitry when in the open position, and control circuitry configured to provide a control signal, where the power relay mechanism includes a motor actuator coupled to the control circuitry, the motor actuator being responsive to the control signal to change the power relay mechanism from the open position to the closed position.