Patents by Inventor Ashok Bhandari

Ashok Bhandari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide Inhibitors of Interleukin-23 Receptor
    Publication number: 20240279281
    Abstract: The present disclosure relates to peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
    Type: Application
    Filed: January 15, 2024
    Publication date: August 22, 2024
    Inventors: Stephanie A. BARROS, Santhosh Francis Neelamkavil, Chengzao SUN, Boying Guo, Charles Hendrick, David Marcoux, Sandeep Somani, Tho Thieu, Jing Zhang, Danila Branca, Roberto Costante, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick
  • COMPOSITIONS OF PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR
    Publication number: 20240254180
    Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
    Type: Application
    Filed: January 25, 2024
    Publication date: August 1, 2024
    Inventors: Giustino DI PRETORO, Dajun SUN, Gopal RAJAN, Geraldine BROECKX, Nathalie MERTENS, Shu LI, Felix LAI, Mohammad MASJEDIZADEH, Anne M. FOURIE, Beverly KNIGHT, David POLIDORI, Santhosh Francis NEELAMKAVIL, Nishit MODI, Ashok BHANDARI, Xiaoli CHENG
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240226225
    Abstract: The present invention generally relates to peptide analogues, including both monomers and dimers, exhibiting hepcidin activity with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof in the treatment and/or prevention of conditions or disorders, including erythrocytoses, such as polycytemia vera, iron overload diseases such as hereditary hemochromatosis: iron-loading anemias, and other conditions and disorders.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 11, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Mark Leslie SMYTHE
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240209024
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: August 7, 2023
    Publication date: June 27, 2024
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Brian Troy FREDERICK, Jie ZHANG, Adam STEPHENSON, Mark Leslie SMYTHE, Roopa TARANATH, David Y. LIU
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240209053
    Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including both peptide monomers and peptide dimers, and conjugates and derivatives thereof, as well as compositions comprising the peptide analogues, and to the use of the peptide analogues in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of erythrocytoses, such as polycytemia vera, iron overload diseases such as hereditary hemochromatosis, iron-loading anemias, and other conditions and disorders described herein.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 27, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI
  • A4B7 THIOETHER PEPTIDE DIMER ANTAGONISTS
    Publication number: 20240209026
    Abstract: The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of a4?7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.
    Type: Application
    Filed: November 3, 2023
    Publication date: June 27, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Ashok BHANDARI, Dinesh V. PATEL, Genet ZEMEDE, Brian Troy FREDERICK, Larry C. MATTHEAKIS, David LIU
  • Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
    Patent number: 12018057
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: June 25, 2024
    Assignees: Janssen Biotech, Inc., Protagonist Therapeutics, Inc.
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Ashok Bhandari, Raymond Patch, Stephanie Barros, Raffaele Ingenito, Roberto Costante, Danila Branca, Elisabetta Bianchi
  • ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
    Publication number: 20240199700
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Application
    Filed: December 1, 2023
    Publication date: June 20, 2024
    Inventors: Ashok BHANDARI, Gregory Thomas BOURNE, Xiaoli CHENG, Brian Troy FREDERICK, Jie ZHANG, Dinesh V. PATEL, David LIU
  • LIPIDATED PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR
    Publication number: 20240173309
    Abstract: The present invention relates to novel lipidated peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts, solvates and/or other forms thereof, corresponding pharmaceutical compositions, methods and/or uses of the IL-23R inhibitors for treatment of autoimmune inflammation diseases and/or related disorders.
    Type: Application
    Filed: October 26, 2023
    Publication date: May 30, 2024
    Inventors: Santhosh NEELAMKAVIL, Chengzao SUN, Sandeep SOMANI, Stephanie A. BARROS, Raymond J. PATCH, Jing ZHANG, Douglas RIEXINGER, Charles HENDRICK, Elisabetta BIANCHI, Roberto COSTANTE, Federica ROSOLIA, Martina LOLLOBRIGIDA, Sonia DEL RIZZO, Danila BRANCA, Ashok BHANDARI, James DANIEL, Tran Trung TRAN, Brian FREDERICK
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20240150405
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: October 23, 2023
    Publication date: May 9, 2024
    Inventors: Chengzao SUN, Brian Troy FREDERICK, Sandeep SOMANI, Gregory Thomas BOURNE, Raymond PATCH, Ashok BHANDARI, Raffaele INGENITO, Roberto COSTANTE, Danila BRANCA, Elisabetta BIANCHI
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20240132558
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 13, 2023
    Publication date: April 25, 2024
    Inventors: Ashok BHANDARI, Gregory Thomas BOURNE
  • Compositions of peptide inhibitors of Interleukin-23 receptor
    Patent number: 11939361
    Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: March 26, 2024
    Assignees: Janssen Pharmaceutica NV, Protagonist Therapeutics, Inc.
    Inventors: Giustino Di Pretoro, Dajun Sun, Gopal Rajan, Geraldine Broeckx, Nathalie Mertens, Shu Li, Felix Lai, Mohammad Masjedizadeh, Anne M. Fourie, Beverly Knight, David Polidori, Santhosh Francis Neelamkavil, Nishit Modi, Ashok Bhandari, Xiaoli Cheng
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240066131
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 28, 2021
    Publication date: February 29, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Jie ZHANG, Brian Troy FREDERICK, Mark Leslie SMYTHE
  • Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
    Patent number: 11884748
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: January 30, 2024
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Gregory Thomas Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240018189
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 28, 2021
    Publication date: January 18, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Jie ZHANG, Brian Troy FREDERICK, Mark Leslie SMYTHE
  • Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
    Patent number: 11845808
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: December 19, 2023
    Assignees: Janssen Biotech, Inc., Protagonist Therapeutics, Inc.
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Gregory Thomas Bourne, Raymond Patch, Ashok Bhandari
  • ?4?7 thioether peptide dimer antagonists
    Patent number: 11840581
    Abstract: The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of ?4?7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: December 12, 2023
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Dinesh V. Patel, Genet Zemede, Brian Troy Frederick, Larry C. Mattheakis, David Liu
  • Conjugated Hepcidin Mimetics
    Publication number: 20230295259
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 28, 2021
    Publication date: September 21, 2023
    Inventors: Gregory Thomas Bourne, Ashok Bhandari, Jie Zhang, Brian Troy Frederick, Mark Leslie Smythe, Roopa Taranath
  • Conjugated hepcidin mimetics
    Patent number: 11753443
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: September 12, 2023
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas Bourne, Ashok Bhandari, Brian Troy Frederick, Jie Zhang, Adam Stephenson, Mark Leslie Smythe, Roopa Taranath, David Liu
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20230129095
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 14, 2021
    Publication date: April 27, 2023
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Ashok BHANDARI, Brian Troy FREDERICK, Tran Trung TRAN, Gregory Thomas BOURNE