Patents by Inventor Ashok Bhandari

Ashok Bhandari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugated Hepcidin Mimetics
    Publication number: 20230295259
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 28, 2021
    Publication date: September 21, 2023
    Inventors: Gregory Thomas Bourne, Ashok Bhandari, Jie Zhang, Brian Troy Frederick, Mark Leslie Smythe, Roopa Taranath
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20230129095
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 14, 2021
    Publication date: April 27, 2023
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Ashok BHANDARI, Brian Troy FREDERICK, Tran Trung TRAN, Gregory Thomas BOURNE
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20220402983
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 14, 2021
    Publication date: December 22, 2022
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Ashok Bhandari, Raymond Patch, Stephanie Barros, Raffaele Ingenito, Roberto Costante, Danila Branca, Elisabetta Bianchi
  • Analogues of hepcidin mimetics with improved in vivo half lives
    Patent number: 11472842
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: October 18, 2022
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas Bourne, Mark Leslie Smythe, Brian Troy Frederick, Ashok Bhandari
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20220251142
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: December 13, 2021
    Publication date: August 11, 2022
    Inventors: Ashok BHANDARI, Brian Troy Frederick, David Clifford Sullivan
  • METHODS FOR SYNTHESIZING BETA-HOMOAMINO ACIDS
    Publication number: 20220185846
    Abstract: Methods of making ?-homoamino acids as intermediate for synthesis of peptide monmer and dimer ?4?7-antagonists are disclosed. The disclosed methods include solid phase and solution phase methods.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 16, 2022
    Inventors: Suresh Kumar MANTHATI, Ashok BHANDARI, Mohammad Reza MASJEDIZADEH
  • NOVEL a4B7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
    Publication number: 20220162261
    Abstract: The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of ?4?7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against ?4?1 binding, and have high stability under gastrointestinal conditions.
    Type: Application
    Filed: July 16, 2021
    Publication date: May 26, 2022
    Inventors: Ashok BHANDARI, Dinesh V. PATEL, Genet ZEMEDE, Larry C. MATTHEAKIS, David LIU
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20220041658
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: May 7, 2021
    Publication date: February 10, 2022
    Inventors: Ashok Bhandari, Brian Troy Frederick, David Clifford Sullivan
  • NOVEL a4B7 THIOETHER PEPTIDE DIMER ANTAGONISTS
    Publication number: 20210371466
    Abstract: The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of ?4?7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.
    Type: Application
    Filed: December 29, 2020
    Publication date: December 2, 2021
    Inventors: Ashok Bhandari, Dinesh V. Patel, Genet Zemede, Brian Troy Frederick, Larry C. Mattheakis, David Liu
  • ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
    Publication number: 20210363185
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Application
    Filed: January 28, 2021
    Publication date: November 25, 2021
    Inventors: Ashok BHANDARI, Gregory Thomas Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • ?4?7 peptide monomer and dimer antagonists
    Patent number: 11111272
    Abstract: The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of ?4?7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against ?4?1 binding, and have high stability under gastrointestinal conditions.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: September 7, 2021
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Dinesh V. Patel, Genet Zemede, Larry C. Mattheakis, David Liu
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20210261622
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 14, 2021
    Publication date: August 26, 2021
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Gregory Thomas Bourne, Raymond Patch, Ashok Bhandari, Raffaele Ingenito, Roberto Costante, Danila Branca, Elisabetta Bianchi
  • Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
    Patent number: 11041000
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: June 22, 2021
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Brian Troy Frederick, David Clifford Sullivan
  • ANALOGUES OF HEPCIDIN MIMETICS WITH IMPROVED IN VIVO HALF LIFES
    Publication number: 20210147483
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: October 1, 2020
    Publication date: May 20, 2021
    Inventors: Gregory Thomas Bourne, Mark Leslie Smythe, Brian Troy Frederick, Ashok Bhandari
  • Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
    Patent number: 10941183
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: March 9, 2021
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Gregory Thomas Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20210009638
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: August 24, 2020
    Publication date: January 14, 2021
    Inventors: Ashok Bhandari, Brian Troy Frederick, David Clifford Sullivan
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20200361992
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: February 8, 2019
    Publication date: November 19, 2020
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Brian Troy FREDERICK, Jie ZHANG, Adam STEPHENSON, Mark Leslie SMYTHE, Roopa TARANATH, David LIU
  • NOVEL a4B7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
    Publication number: 20200308229
    Abstract: The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of ?4?7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against ?4?1 binding, and have high stability under gastrointestinal conditions.
    Type: Application
    Filed: February 4, 2020
    Publication date: October 1, 2020
    Inventors: Ashok BHANDARI, Dinesh V. PATEL, Genet Zemede, Larry C. Mattheakis, David Liu
  • Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
    Patent number: 10787490
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases, are described.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: September 29, 2020
    Assignee: Protaganist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Gregory Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • Opioid agonist peptides and uses thereof
    Patent number: 10729676
    Abstract: The invention is directed to opioid agonist peptides and their use.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 4, 2020
    Assignee: Protagonist Theraputics, Inc.
    Inventors: Sampath Kumar Anandan, Jie Zhang, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick, Larry C. Mattheakis, David Liu, Mukund M. Mehrotra