Abstract: This invention is related to a flexible sheet structure useful in garments for providing combination flash flame and chemical splash protection, and a garment comprising such flexible sheet structure, the flexible sheet structure comprising a fabric layer comprising flame retardant fibers, a chemical barrier layer being able to provide greater than 60 minute chemical permeation pursuant to ASTM F739 for at least 11 of the 21 chemicals listed in this test procedure, and a continuous outer polymer layer; the flexible sheet structure having a thermal shrinkage resistance of less than 10 percent when tested according to NFPA 2112, and having an after flame performance of less than 2 seconds and a char length of not more than 4 inches (100 mm) when tested per ASTM D6413.