Patents by Inventor Ashok J. Chavan

Ashok J. Chavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indocyanine green (ICG) compositions and related methods of use
    Patent number: 6944493
    Abstract: Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: September 13, 2005
    Assignee: Akora, Inc.
    Inventors: Abu Alam, Ashok J. Chavan, Robert W. Flower
  • Oligonucleotide delivery systems for camptothecins
    Patent number: 6897200
    Abstract: Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: May 24, 2005
    Assignee: University of Kentucky Research Foundation
    Inventors: Thomas G. Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang
  • Methods of using indocyanine green (ICG) dye
    Publication number: 20040156782
    Abstract: Methods of using indocyanine green (ICG) dye for obtaining angiographic images of tissue in a patient, determining cardiac output or hepatic function and liver blood flow, and diagnosing and treating a lesion. In each method, an aqueous ICG composition is administered to the patient more than 10 hours after the ICG has been reconstituted to form the aqueous ICG composition, and up to a maximum time limit as determined using HPLC analysis of ICG.
    Type: Application
    Filed: February 12, 2003
    Publication date: August 12, 2004
    Applicant: Akorn, Inc.
    Inventors: Abu Alam, Ashok J. Chavan
  • Indocyanine green (ICG) compositions and related methods of use
    Publication number: 20030060718
    Abstract: Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.
    Type: Application
    Filed: December 27, 2001
    Publication date: March 27, 2003
    Applicant: Akorn, Inc.
    Inventors: Abu Alam, Ashok J. Chavan, Robert W. Flower
  • Water-soluble derivatives of camptothecin/homocamptothecin
    Patent number: 6291676
    Abstract: Camptothecin and homocamptothecin analogs and derivatives are provided incorporating alkylamine and polyalkylamine moieties.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: September 18, 2001
    Assignee: University of Kentucky Research Foundation
    Inventors: Thomas G. Burke, Ayhan S. Demir, Cihangir Tanyeli, Ashok J. Chavan, Tie-Lin Wang, Yves Pommier